Detalle Publicación

ARTÍCULO
Liposomes and lipopolymeric carriers for gene delivery
Título de la revista: JOURNAL OF MICROENCAPSULATION
ISSN: 0265-2048
Volumen: 27
Número: 7
Páginas: 602 - 608
Fecha de publicación: 2010
Resumen:
In this work we have examined the ability of various lipopolyplexes to deliver genes into liver cancer cells. We evaluated different parameters such as the protocol of preparation, the lipid/DNA molar ratio, and the molecular weight and type of PEI, to optimize the formulation to achieve high transfection activity. Our hypothesis was that the association of PEI with cationic liposomes (lipopolyplexes) would increase luciferase expression compared to lipoplexes (cationic lipid and DNA) and polyplexes (cationic polymer and DNA) alone.