Detalle Publicación


Better performance of CARs deprived of the PD-1 brake

Título de la revista: CLINICAL CANCER RESEARCH
ISSN: 1078-0432
Volumen: 19
Número: 20
Páginas: 5546 - 5548
Fecha de publicación: 2013
Immunotherapies often permit combinations to increase efficacy. Two approaches are currently leading our field: adoptive therapy with T cells transfected with chimeric antigen receptors and monoclonal antibodies blocking the PD-1/PD-L1 (B7-H1) axis. In this issue of Clinical Cancer Research, preclinical evidence for a synergistic combination of such approaches is reported.