Detalle Publicación

High-density lipoproteins delivering interleukin-15

Título de la revista: ONCOIMMUNOLOGY
ISSN: 2162-4011
Volumen: 2
Número: 4
Páginas: e23410
Fecha de publicación: 2013
Circulating lipoproteins may offer interesting properties as therapeutic carriers for cytokines and hormones, in terms of both stability and bio-distribution. The fusion of apolipoprotein A-I with interleukin-15 (IL-15) targets the latter to high-density lipoproteins (HDLs). The bioactivity of this chimera can be further enhanced by creating triple fusions with IL-15 receptor ¿ domain involved in IL-15 trans-presentation.