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ARTÍCULO

Association of adiposity and its changes over time with COVID-19 risk in older adults with overweight/obesity and metabolic syndrome: a longitudinal evaluation in the PREDIMED-Plus cohort

Autores: Shyam, S. (Autor de correspondencia); García-Gavilán, J. F.; Paz-Graniel, I.; Gaforio, J. J.; Martínez González, Miguel Ángel; Corella, D.; Martínez Hernández, Alfredo; Alonso-Gómez, A. M.; Waernberg, J.; Vioque, J.; Romaguera, D.; López-Miranda, J.; Estruch, R.; Tinahones, F. J.; Lapetra, J.; Serra-Majem, J. L.; Bueno-Cavanillas, A.; Tur, J. A.; Martín Sánchez, V.; Pinto, X.; Matía-Martín, P.; Vidal, J.; Vázquez, C.; Daimiel, L.; Ros, E.; Fernández-Aranda, F.; Nishi, S. K.; García-Regata, O.; Toledo, E.; Asensio, E. M.; Castañer, O.; García-Ríos, A.; Torres-Collado, L.; Gómez-Gracia, E.; Zulet Alzórriz, María de los Ángeles; Goñi Ruiz, N.; Casas, R.; Cano-Ibáñez, N.; Tojal-Sierra, L.; Gómez-Pérez, A. M.; Sorlí, J. V.; Cinza-Sanjurjo, S.; Martín-Peláez, S.; Peña-Orihuela, P. J.; Oncina-Cánovas, A.; Pérez Araluce, Rafael María; Zomeño, M. D.; Chaplin, A.; Delgado-Rodríguez, M.; Babio, N.
Título de la revista: BMC MEDICINE
ISSN: 1741-7015
Volumen: 21
Número: 1
Páginas: 390
Fecha de publicación: 2023
Resumen:
Background Cross-sectionally, older age and obesity are associated with increased coronavirus disease-2019 (COVID-19) risk. We assessed the longitudinal associations of baseline and changes in adiposity parameters with COVID-19 incidence in older adults at high cardiovascular risk.Methods This analysis included 6874 men and women (aged 55-75 years) with overweight/obesity and metabolic syndrome in the PREDIMED-Plus lifestyle intervention trial for cardiovascular risk reduction. Body weight, body-mass-index (BMI), waist circumference, waist-to-height ratio (WHtR), and a body shape index (ABSI) were measured at baseline and annual follow-up visits. COVID-19 was ascertained by an independent Event Committee until 31 December 2021. Cox regression models were fitted to evaluate the risk of COVID-19 incidence based on baseline adiposity parameters measured 5-6 years before the pandemic and their changes at the visit prior to censoring.Results At the time of censoring, 653 incident COVID-19 cases occurred. Higher baseline body weight, BMI, waist circumference, and WHtR were associated with increased COVID-19 risk. During the follow-up, every unit increase in body weight (HRadj (95%CI): 1.01 (1.00, 1.03)) and BMI (HRadj: 1.04 (1.003, 1.08)) was associated with increased COVID-19 risk.Conclusions In older adults with overweight/obesity, clinically significant weight loss may protect against COVID-19.
DOI: https://doi.org/10.1186/s12916-023-03079-z
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