This study presents the analysis of the methodology of a seismic exposure model in Guatemala City. In the last years, progress in the investigation of regional seismic hazards has revealed the need to study the vulnerability of buildings in Central America. In addition, in recent years there have been earthquakes of moderate magnitude in Guatemala causing damage in some areas of the country. An accurate exposure model and updated threat scenarios are essential for a detailed vulnerability study. This exposure study for Guatemala City reveals the presence of structural typologies that are very vulnerable to earthquakes: adobe and simple masonry. Similarly, the study reveals the majority presence of reinforced masonry and the growing construction of reinforced concrete buildings. The characteristic of this model is the use of historical aerial photographs of Guatemala City to determine the relationship between constructive typologies. The lack of exposure studies in the country has prevented the creation of policies to reduce vulnerability to a catastrophe like the earthquake in 1976. The analysis and methodology presented in this study are the preliminary step in formulating seismic risk prevention and mitigation plans in Guatemala City; knowledge of the city's exposure contributes to making subsequent actions more effective. Based on the results obtained, matrices are proposed according to the age and material of the buildings for the typological classification of the structures.