Detalle Publicación


Phytosterol-mediated inhibition of intestinal cholesterol absorption is independent of liver X receptor

Autores: Cedó, L.; Santos, D.; Ludwig Sanz Orrio, Iziar Amaia; Silvennoinen, R.; García-León, A.; Kaipianinen, L.; Carbó, J. M.; Valledor, A. F.; Gylling, H.; Motilva, M. J.; Kovanen, P. T.; Lee-Rueckert, M.; Blanco-Vaca, F. (Autor de correspondencia); Escolà-Gil, J. C. (Autor de correspondencia)
ISSN: 1613-4125
Volumen: 61
Número: 9
Páginas: 1700055
Fecha de publicación: 2017
Scope: Previous studies have proposed that phytosterols activate liver X receptors (LXR) in the intestine, thereby reducing intestinal cholesterol absorption and promoting fecal cholesterol excretion. Methods and results: In the present study, we examined the effects of dietary phytosterol supplementation on intestinal cholesterol absorption and fecal neutral sterol excretion in LXR alpha beta-deficient mice, and wild-type mice treated with synthetic high-affinity LXR alpha beta agonists. LXR alpha beta deficiency led to an induction of intestinal cholesterol absorption and liver cholesterol accumulation. Phytosterol feeding resulted in an approximately 40% reduction of intestinal cholesterol absorption both in wild-type and LXR alpha beta-deficient mice, reduced dietary cholesterol accumulation in liver and promoted the excretion of fecal cholesterol-derived compounds. Furthermore, phytosterols produced additive inhibitory effects on cholesterol absorption in mice treated with LXR alpha beta agonists. Conclusions: Our data confirm the effect of LXR in regulating intestinal cholesterol absorption and demonstrate that the cholesterol-lowering effects of phytosterols occur in an LXR-independent manner.