Detalle Publicación

Modulating the systemic and local adaptive immune response after fracture improves bone regeneration during aging
Autores: Muiños Lopez, Emma; Leclerc, K.; Ramsukh, M.; El Parente, P.; Patel, K.; Aranda, C. J.; Josephson, A. M.; Remark, L. H.; Kirby, D. J.; Buchalter, D. B.; Hadi, T.; Morgani, S. M.; Ramkhelawon, B.; Leucht, P. (Autor de correspondencia)
Título de la revista: BONE
ISSN: 8756-3282
Volumen: 157
Páginas: 116324
Fecha de publicación: 2022
Tissue injury leads to the well-orchestrated mobilization of systemic and local innate and adaptive immune cells. During aging, immune cell recruitment is dysregulated, resulting in an aberrant inflammatory response that is detrimental for successful healing. Here, we precisely define the systemic and local immune cell response after femur fracture in young and aging mice and identify increased toll-like receptor signaling as a potential culprit for the abnormal immune cell recruitment observed in aging animals. Myd88, an upstream regulator of TLR-signaling lies at the core of this aging phenotype, and local treatment of femur fractures with a Myd88 antagonist in middle-aged mice reverses the aging phenotype of impaired fracture healing, thus offering a promising therapeutic target that could overcome the negative impact of aging on bone regeneration.