Detalle Publicación

ARTÍCULO
Impacto de la edad del donante-receptor en la supervivencia al trasplante cardiaco: Subanálisis del Registro Español de Trasplante Cardiaco
Autores: López-Vilella, R. (Autor de correspondencia); González-Vílchez, F.; Crespo-Leiro, M. G.; Segovia-Cubero, J.; Cobo, M.; Delgado-Jiménez, J.; Arizón del Prado, J. M.; Martínez-Selles, M.; Sobrino Márquez, J. M.; Mirabet-Pérez, S.; González-Costello, J.; Pérez-Villa, F.; Lambert-Rodríguez, J. L.; Rabago Juan Aracil, Gregorio; Blasco-Peiro, M. T.; de la Fuente-Galán, L.; Garrido-Bravo, I.; Otero, D.; Almenar-Bonet, L.
Título de la revista: REVISTA ESPAÑOLA DE CARDIOLOGIA
ISSN: 0300-8932
Volumen: 74
Número: 5
Páginas: 393 - 401
Fecha de publicación: 2021
Lugar: WOS
Resumen:
Introduction and objectives: The age of heart transplant recipients and donors is progressively increasing. It is likely that not all donor-recipient age combinations have the same impact on mortality. The objective of this work was to compare survival in transplant recipients according to donor-recipient age combinations. Methods: We performed a retrospective analysis of transplants performed between 1 January 1993 and 31 December 2017 in the Spanish Heart Transplant Registry. Pediatric transplants, retransplants and combined transplants were excluded (6505 transplants included). Four groups were considered: a) donor < 50 years for recipient < 65 years; b) donor < 50 years for recipient >= 65 years; c) donor >= 50 years for recipient >= 65 years, and d) donor >= 50 years for recipient < 65 years. Results: The most frequent group was young donor for young recipient (73%). There were differences in the median survival between the groups (P<.001): a) younger-younger: 12.1 years, 95%CI, 11.5-12.6; b) younger-older: 9.1 years, 95%CI, 8.0-10.5; c) older-older: 7.5 years, 95%CI, 2.8-11.0; d) older-younger: 10.5 years, 95%CI, 9.6-12.1. On multivariate analysis, independent predictors of mortality were the age of the donor and the recipient (0.008 and 0.001, respectively). The worst combinations were older-older vs younger-younger (HR, 1.57; 95%CI, 1.22-2.01; P<.001) and younger-older vs younger-younger (HR, 1.33; 95%CI, 1.12-1.58; P=.001). Conclusions: Age (of the donor and recipient) is a relevant prognostic factor in heart transplant. The donor-recipient age combination has prognostic implications that should be identified when accepting an organ for transplant. (C) 2020 Sociedad Espanola de Cardiologia. Published by Elsevier Espana, S.L.U. All rights reserved.