Detalle Publicación

ARTÍCULO
Development and Therapeutic Potential of Selenazo Compounds
Título de la revista: JOURNAL OF MEDICINAL CHEMISTRY
ISSN: 0022-2623
Volumen: 63
Número: 4
Páginas: 1473 - 1489
Fecha de publicación: 2020
Lugar: WOS
Resumen:
Incorporation of selenium (Se) atom into small molecules can substantially enhance their antioxidant, anti-inflammatory, antimutagenic, antitumoral or chemopreventive, antiviral, antibacterial, antifungal, antiparasitic, and neuroprotective effects. Specifically, selenazo compounds have received great attention owing to their chemical properties, pharmaceutical applications, and low toxicity. In this Perspective, we compile extensive literature evidence with the description and discussion of the most recent advances in different selenazo and selenadiazo motifs as potential pharmacological candidates. We also provide some perspectives on the challenges and future directions in the advancement of these selenazo compounds, each of which could generate drug candidates for various diseases.