Detalle Publicación

Vaccine development targeting lipopolysaccharide structure modification
Autores: Zhao, Y.; Arce-Gorvel, V.; Conde Álvarez, Raquel; Moriyón Uría, Ignacio; Gorvel, J. P.
Título de la revista: MICROBES AND INFECTION
ISSN: 1286-4579
Volumen: 20
Número: 9 - 10
Páginas: 455 - 460
Fecha de publicación: 2018
Vaccines are one of the most important methods for preventing infectious disease. Structural modification of lipopolysaccharide (LPS) provides a strategy for the development of live attenuated vaccines, either by altering the immunogenicity or by attenuating virulence of the bacteria. This review summarizes various approaches that utilize LPS mutants as whole-cell vaccines.