Detalle Publicación


Priming of dendritic cells by DNA-containing extracellular vesicles from activated T cells through antigen-driven contacts

Autores: Torralba, D.; Baixauli, F. ; Villarroya-Beltri, C.; Fernandez-Delgado, I. ; Latorre-Pellicer, A. ; Acin-Perez, R. ; Martin-Cofreces, N. B. ; Jaso-Tamame, A. L.; Iborra, S. ; Jorge, I.; González Aseguinolaza, Gloria; Garaude, J.; Vicente-Manzanares, M. ; Enriquez, J. A.; Mittelbrunn, M.; Sanchez-Madrid, F. (Autor de correspondencia)
Título de la revista: NATURE COMMUNICATIONS
ISSN: 2041-1723
Volumen: 9
Fecha de publicación: 2018
Interaction of T cell with antigen-bearing dendritic cells (DC) results in T cell activation, but whether this interaction has physiological consequences on DC function is largely unexplored. Here we show that when antigen-bearing DCs contact T cells, DCs initiate antipathogenic programs. Signals of this interaction are transmitted from the T cell to the DC, through extracellular vesicles (EV) that contain genomic and mitochondrial DNA, to induce antiviral responses via the cGAS/STING cytosolic DNA-sensing pathway and expression of IRF3-dependent interferon regulated genes. Moreover, EV-treated DCs are more resistant to subsequent viral infections. In summary, our results show that T cells prime DCs through the transfer of exosomal DNA, supporting a specific role for antigen-dependent contacts in conferring protection to DCs against pathogen infection. The reciprocal communication between innate and adaptive immune cells thus allow efficacious responses to unknown threats.