Detalle Publicación


Anti-CD137 and PD-1/PD-L1 Antibodies En Route toward Clinical Synergy

Título de la revista: CLINICAL CANCER RESEARCH
ISSN: 1078-0432
Volumen: 23
Número: 18
Páginas: 5326 - 5328
Fecha de publicación: 2017
T-cell costimulation and coinhibition can be respectively exploited by blocking and agonist mAbs. Both strategies can be synergistically combined in mouse models. Early clinical results from combinations of anti-PD-1 mAbs in conjunc-tion with agonist anti-CD137 (4-1BB) mAbs show excellent safety and promising efficacy. (C) 2017 AACR.