Detalle Publicación

Thalamic Deep Brain Stimulation for Orthostatic Tremor: A Multicenter International Registry
Autores: Merola, A.; Fasano, A. ; Hassan, A.; Ostrem, J. L. ; Contarino, M. F. ; Lyons, M.; Krauss, J.K. ; Wolf, M. E. ; Klassen, B. T. ; Van Rootselaar, A.F. ; Regidor, I. ; Duker, A. P. ; Ondo, W. ; Guridi Legarra, Jorge; Volkmann, J. ; Shukla, AW. ; Mandybur, G. T. ; Okun, M. S. ; Witt, K.; Starr, P. A. ; Deuschl, G. ; Espay, A. J
Título de la revista: MOVEMENT DISORDERS
ISSN: 0885-3185
Volumen: 32
Número: 8
Páginas: 1240 - 1244
Fecha de publicación: 2017
Lugar: WOS
Background: We report the accumulated experience with ventral intermediate nucleus deep brain stimulation for medically refractory orthostatic tremor. Methods: Data from 17 patients were reviewed, comparing presurgical, short-term (0-48 months), and long-term (>= 48 months) follow-up. The primary end point was the composite activities of daily living/instrumental activities of daily living score. Secondary end points included latency of symptoms on standing and treatment-related complications. Results: There was a 21.6% improvement (P = 0.004) in the composite activities of daily living/instrumental activities of daily living score, which gradually attenuated (12.5%) in the subgroup of patients with an additional long-term follow-up (8 of 17). The latency of symptoms on standing significantly improved, both in the shortterm (P = 0.001) and in the long-term (P = 0.018). Three patients obtained no/minimal benefit from the procedure. Conclusions: Deep brain stimulation of the ventral intermediate nucleus was, in general, safe and well tolerated, yielding sustained benefit in selected patients with medically refractory orthostatic tremor. (C) 2017 International