Detalle Publicación

ARTÍCULO
Combined PI3K/Akt and Smad2 activation promotes corneal endothelial cell proliferation
Título de la revista: INVESTIGATIVE OPHTHALMOLOGY AND VISUAL SCIENCE
ISSN: 0146-0404
Volumen: 58
Número: 2
Páginas: 745-754
Fecha de publicación: 2017
Resumen:
We demonstrated that the combined activation of PI3K/Akt and Smad2 results in in vitro expansion of phenotypic and functional CEC. Expanded cells were able to contribute to restoration of corneal endothelium in a rabbit model. These findings may represent a new therapeutic approach for treating corneal endothelial diseases