Detalle Publicación


Oscillatory activity in the basal ganglia and deep brain stimulation

Título de la revista: MOVEMENT DISORDERS
ISSN: 0885-3185
Volumen: 32
Número: 1
Páginas: 64 - 69
Fecha de publicación: 2017
Over the past 10 years, research into the neurophysiology of the basal ganglia has provided new insights into the pathophysiology of movement disorders. The presence of pathological oscillations at specific frequencies has been linked to different signs and symptoms in PD and dystonia, suggesting a new model to explain basal ganglia dysfunction. These advances occurred in parallel with improvements in imaging and neurosurgical techniques, both of which having facilitated the more widespread use of DBS to modulate dysfunctional circuits. High-frequency stimulation is thought to disrupt pathological activity in the motor cortex/ basal ganglia network; however, it is not easy to explain all of its effects based only on changes in network oscillations. In this viewpoint, we suggest that a return to (C) 2016 International Parkinson and Movement Disorder Society