Detalle Publicación

Synthesis, biological evaluation and structure-activity relationships of new quinoxaline derivatives as anti-Plasmodium falciparum agents

Autores: Gil Royo, Ana Gloria; Pabón, A.; Galiano Ruiz, Silvia; Burguete Pérez, María Asunción; Pérez Silanes, Silvia; Deharo, E.; Monge Vega, Antonio; Aldana Moraza, Ignacio
Título de la revista: MOLECULES
ISSN: 1420-3049
Volumen: 19
Número: 2
Páginas: 2166 - 2180
Fecha de publicación: 2014
Resumen:
We report the synthesis and antimalarial activities of eighteen quinoxaline and quinoxaline 1,4-di-N-oxide derivatives, eight of which are completely novel. Compounds 1a and 2a were the most active against Plasmodium falciparum strains. Structure-activity relationships demonstrated the importance of an enone moiety linked to the quinoxaline ring.
DOI: https://doi.org/10.3390/molecules19022166
Impacto:
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