Detalle Publicación

ARTÍCULO
Synthesis, biological evaluation and structure-activity relationships of new quinoxaline derivatives as anti-Plasmodium falciparum agents
Título de la revista: MOLECULES
ISSN: 1420-3049
Volumen: 19
Número: 2
Páginas: 2166 - 2180
Fecha de publicación: 2014
Resumen:
We report the synthesis and antimalarial activities of eighteen quinoxaline and quinoxaline 1,4-di-N-oxide derivatives, eight of which are completely novel. Compounds 1a and 2a were the most active against Plasmodium falciparum strains. Structure-activity relationships demonstrated the importance of an enone moiety linked to the quinoxaline ring.