Detalle Publicación

ARTÍCULO
Exploring the scope of new arylamino alcohol derivatives: Synthesis, antimalarial evaluation, toxicological studies, and target exploration
Autores: Quiliano, M.; Mendoza Lizaldez, Adela; Fong, K. Y.; Pabon, A.; Goldfarb, N. E.; Fabing, I.; Vettorazzi Armental, Ariane; López de Cerain Salsamendi, Adela; Dunn, B. M.; Garavito, G.; Wright, D. W.; Deharo, E. ; Pérez Silanes, Silvia; Aldana Moraza, Ignacio; Galiano Ruiz, Silvia
Título de la revista: INTERNATIONAL JOURNAL FOR PARASITOLOGY, DRUGS AND DRUG RESISTANCE
ISSN: 2211-3207
Volumen: 6
Número: 3
Páginas: 184 - 198
Fecha de publicación: 2016
Lugar: WOS
Resumen:
Synthesis of new 1-aryl-3-substituted propanol derivatives followed by structure-activity relationship, in silico drug-likeness, cytotoxicity, genotoxicity, in silico metabolism, in silico pharmacophore modeling, and in vivo studies led to the identification of compounds 22 and 23 with significant in vitro anti-plasmodial activity against drug sensitive (D6 IC50 <= 0.19 mu M) and multidrug resistant (FCR-3 IC50 <= 0.40 mu M and C235 IC50 <= 0.28 mu M) strains of Plasmodium falciparum. Adequate selectivity index and absence of genotoxicity was also observed. Notably, compound 22 displays excellent parasitemia reduction (98 +/- 1%), and complete cure with all treated mice surviving through the entire period with no signs of toxicity. One important factor is the agreement between in vitro potency and in vivo studies. Target exploration was performed; this chemotype series exhibits an alternative antimalarial mechanism. (C) 2016 The Authors. Published by Elsevier Ltd on behalf of Australian Society for Parasitology.