Detalle Publicación

ARTÍCULO

Structures for G-protein-coupled receptor tetramers in complex with G proteins

Autores: Cordomí, A.; Navarro, G.; Aymerich Soler, Marisol; Franco Fernández, Rafael
Título de la revista: TRENDS IN BIOCHEMICAL SCIENCES
ISSN: 0968-0004
Volumen: 40
Número: 10
Páginas: 548 - 551
Fecha de publicación: 2015
Resumen:
G-Protein-coupled receptors (GPCRs) were classically described as monomers. We now appreciate that they also function as homo- and hetero-oligomers, for which structural information is lacking. Here, we use available 3D structures and biochemical considerations to present and evaluate experimentally testable structural models for GPCR oligomers and associated G proteins.
DOI: https://doi.org/10.1016/j.tibs.2015.07.007
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