The highest authority at the University is the Chancellor, who exercises all of the powers and functions necessary for good governance. This position is held by the Prelate of Opus Dei.

Since its establishment, the University has had three Chancellors, in addition to its founder, St. Josemaría Escrivá de Balaguer: Mons. Álvaro del Portillo, the first successor to the Opus Dei founder; Mons. Javier Echevarría; and Mons. Fernando Ocáriz, the current Chancellor and Prelate of Opus Dei.

In the Chancellor's absence, the Vice Chancellor presides over the University, and also exercises all functions delegated by the Chancellor.

The current Vice Chancellor of the University is Mons. Ignacio Barrera, the Vicar of Opus Dei in Spain.

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