The Nutrition Centre is a basic applied research institution pertaining to the University of Navarra, attached to the Faculty of Pharmacy and endowed with the autonomy to execute its objectives. The different research studies done to date have generated several publications, such as posters, articles and congresses among others, written by researchers and PhD students who have participated in the different research projects. In this section, you will find the most important publications.

1.    Title of the project: Desarrollo y validación de ingredientes funcionales y nutracéuticos basados en compuestos bioactivos de origen natural (NUTRAGEN). Principal Investigator: Doctor Carlos Javier González Navarro

2.    de la Garza AL, Etxeberria U, Lostao MP, San Román B, Barrenetxe J, Martínez JA, Milagro FI.J Helichrysum and grapefruit extracts inhibit carbohydrate digestion and absorption, improving postprandial glucose levels and hyperinsulinemia in rats. Agric Food Chem. 2013 Dec 11;61(49):12012-9. 

3.    Boqué N, de la Iglesia R, de la Garza AL, Milagro FI, Olivares M, Bañuelos O, Soria AC, Rodríguez-Sánchez S, Martínez JA, Campión J. Prevention of diet-induced obesity by apple polyphenols in Wistar rats through regulation of adipocyte gene expression and DNA methylation patterns.Mol Nutr Food Res. 2013 Aug;57(8):1473-8.

4.    Boqué N, Campión J, de la Iglesia R, de la Garza AL, Milagro FI, San Román B, Bañuelos Ó, Martínez JA.JScreening of polyphenolic plant extracts for anti-obesity properties in Wistar rats. Sci Food Agric. 2013 Mar 30;93(5):1226-32.

5.    Etxeberria U, de la Garza AL, Campión J, Martínez JA, Milagro FIAntidiabetic effects of natural plant extracts via inhibition of carbohydrate hydrolysis enzymes with emphasis on pancreatic alpha amylase.. Expert Opin Ther Targets. 2012 Mar;16(3):269-97

6.    de la Garza AL, Milagro FI, Boque N, Campión J, Martínez JANatural inhibitors of pancreatic lipase as new players in obesity treatment.Planta Med. 2011 May;77(8):773-85. 

7.    Cordero P, Campion J, Milagro FI, Martínez JADietary supplementation with methyl donor groups could prevent nonalcoholic fatty liver. Hepatology. 2011 Jun;53(6):2151-2.

8.    de la Iglesia R, Milagro FI, Campión J, Boqué N, Martínez JA.Healthy properties of proanthocyanidins. Biofactors. 2010 May-Jun;36(3):159-68.

1.    Nutrición personalizada y biomarcadores nutrigenómicos de la inflamación asociada a la dieta y la obesidad. Papel de nutrientes, obesidad y edad Reference AGL2013-45554-R. Principal Investigators: Prof. Alfredo Martínez Hernández and Dr. Fermín Milagro Yoldi

2.    Proyecto de Investigación  Aplicada en Nutrigenómica de la Obesidad.  Reference PPT 300000-2008-003. Principal investigator: Professor, Doctor Alfredo Martínez Hernández

3.    Lopez-Legarrea P, de la Iglesia R, Abete I, Navas-Carretero S, Martinez JA, Zulet MA. The protein type within a hypocaloric diet affects obesity-related inflammation: The RESMENA project. Nutrition. 2014 Apr;30(4):424-9. doi:10.1016/j.nut.2013.09.009. PubMed PMID: 24607301.

4.    Ibero-Baraibar I, Abete I, Navas-Carretero S, Massis-Zaid A, Martinez JA, Zulet MA. Oxidised LDL levels decreases after the consumption of ready-to-eat meals supplemented with cocoa extract within a hypocaloric diet. Nutr Metab Cardiovasc Dis. 2014 Apr;24(4):416-22. doi: 10.1016/j.numecd.2013.09.017.  2013 Nov 1. PubMed PMID: 24462367.

5.    Bondia-Pons I, Cañellas N, Abete I, Rodríguez MÁ, Perez-Cornago A, Navas-Carretero S, Zulet MÁ, Correig X, Martínez JA. Nutri-metabolomics: subtle serum metabolic differences in healthy subjects by NMR-based metabolomics after a short-term nutritional intervention with two tomato sauces. OMICS. 2013 Dec;17(12):611-8. doi: 10.1089/omi.2013.0027. Epub 2013 Oct 19. PubMed PMID:

6.    Estruch R, Ros E, Salas-Salvadó J, Covas MI, Corella D, Arós F, Gómez Gracia E, Ruiz-Gutiérrez V, Fiol M, Lapetra J, Lamuela-Raventos RM, Serra-Majem L, Pintó X, Basora J, Muñoz MA, Sorlí JV, Martínez JA, Martínez González MAPREDIMED Study Investigators. Primary prevention of cardiovascular disease with a Mediterranean diet. N Engl J Med. 2013 Apr 4;368(14):1279-90. doi: 10.1056/NEJMoa1200303. Epub 2013 Feb 25. Erratum in: N Engl J Med. 2014 Feb 27;370(9):886. PubMed PMID: 23432189.

7.    Larsen TM, Dalskov SM, van Baak M, Jebb SA, Papadaki A, Pfeiffer AF, Martinez  JA, Handjieva-Darlenska T, Kunešová M, Pihlsgård M, Stender S, Holst C, Saris WH, Astrup A; Diet, Obesity, and Genes (Diogenes) Project. Diets with high or low protein content and glycemic index for weight-loss maintenance. N Engl J Med. 2010 Nov 25;363(22):2102-13. doi: 10.1056/NEJMoa1007137. PubMed PMID: 21105792; PubMed Central PMCID: PMC3359496.

8.    Estruch R, Ros E, Salas-Salvadó J, Covas MI, Corella D, Arós F, Gómez-Gracia E, Ruiz-Gutiérrez V, Fiol M, Lapetra J, Lamuela-Raventos RM, Serra Majem L, Pintó X, Basora J, Muñoz MA, Sorlí JV, Martínez JA, Martínez-González MA; PREDIMED Study Investigators. Primary prevention of cardiovascular disease with a Mediterranean diet. N Engl J Med. 2013 Apr 4;368(14):1279-90. doi: 10.1056/NEJMoa1200303. Epub 2013 Feb 25. Erratum in: N Engl J Med. 2014 Feb 27;370(9):886. PubMed PMID: 23432189

1.    Mediadores lipídicos bioactivos derivados de los ácidos grasos omega-3: Potencial aplicación en obesidad, inflamación e insulino-resistencia.  Reference: BFU2012-36089. Principal Investigator: Prof. María Jesús Moreno Aliaga

2.    Fernández-Galilea M, Pérez-Matute P, Prieto-Hontoria PL, Martinez JA, Moreno-Aliaga MJ. Effects of lipoic acid on lipolysis in 3T3-L1 adipocytes. J Lipid Res. 2012;53(11):2296-306.

3.    Valdecantos MP, Pérez-Matute P, González-Muniesa P, Prieto-Hontoria PL, Moreno-Aliaga MJ, Martínez JA. Lipoic acid administration prevents nonalcoholic steatosis linked to long-term high-fat feeding by modulating mitochondrial function. J Nutr Biochem. 2012;23(12):1676-84.

4.    Moreno-Aliaga MJ, Pérez-Echarri N, Marcos-Gómez B, Larequi E, Gil-Bea FJ, Viollet B, Gimenez I, Martínez JA, Prieto J, Bustos M. Cardiotrophin-1 is a key regulator of glucose and lipid metabolism. Cell Metab. 2011;14(2):242-53.

5.    Lorente-Cebrián S, Bustos M, Marti A, Fernández-Galilea M, Martinez JA, Moreno-Aliaga MJ. Eicosapentaenoic acid inhibits tumour necrosis factor-α-induced lipolysis in murine cultured adipocytes. J Nutr Biochem. 2012;23(3):218-27.

6.    Gómez-Ruiz A, Milagro FI, Campión J, Martínez JA, de Miguel C. High-fat diet feeding alters metabolic response to fasting/non fasting conditions. Effect on caveolin expression and insulin signalling. Lipids Health Dis. 2011;10:55.

7.    Gómez-Ruiz A, Milagro FI, Campión J, Martínez JA, de Miguel CCaveolin expression and activation in retroperitoneal and subcutaneous adipocytes: influence of a high-fat diet. J Cell Physiol. 2010;225(1):206-13.

8.    Barrenetxe J, Sánchez O, Barber A, Gascón S, Rodríguez-Yoldi MJ, Lostao MP. TNFα regulates sugar transporters in the human intestinal epithelial cell line Caco-2. Cytokine. 2013;64(1):181-7.

9.    Fanjul C, Barrenetxe J, Iñigo C, Sakar Y, Ducroc R, Barber A, Lostao MPLeptin regulates sugar and amino acids transport in the human intestinal cell line Caco-2. Acta Physiol (Oxf). 2012;205(1):82-91.        

10.  Pujol-Giménez J, Barrenetxe J, González-Muniesa P, Lostao MP. The facilitative glucose transporter GLUT12: what do we know and what would we like to know? J Physiol Biochem. 2013;69(2):325-33.

11.  Quintero P, Gonzalez-Muniesa P, Martinez JA. Influence of different oxygen supply on metabolic markers and gene response in murine adipocytes. J Biol Regul  Homeost Agents. 2012;26(3):379-88.

Higher baseline irisin concentrations are associated with greater reductions in glycemia and insulinemia after weight loss in obese subjects. Lopez-Legarrea P, de la Iglesia R, Crujeiras AB, Pardo M, Casanueva FF, Zulet MA, Martinez JA. Nutr Diabetes. 2014 Feb 24;4:e110. doi: 10.1038/nutd.2014.7.

2. Differential DNA methylation patterns between high and low responders to a weight loss intervention in overweight or obese adolescents: the EVASYON study. Moleres A, Campión J, Milagro FI, Marcos A, Campoy C, Garagorri JM, Gómez-Martínez S, Martínez JA, Azcona-Sanjulián MC, Martí A; EVASYON Study Group. FASEB J. 2013 Jun;27(6):2504-12. doi: 10.1096/fj.12-215566.

3. High-throughput sequencing of microRNAs in peripheral blood mononuclear cells: identification of potential weight loss biomarkers. Milagro FI, Miranda J, Portillo MP, Fernandez-Quintela A, Campión J, Martínez JA. PLoS One. 2013;8(1):e54319. doi: 10.1371/journal.pone.0054319. 

4. Circulating ACE is a predictor of weight loss maintenance not only in overweight and obese women, but also in men. Wang P, Holst C, Wodzig WK, Andersen MR, Astrup A, van Baak MA, Larsen TM, Jebb SA, Kafatos A, Pfeiffer AF, Martinez JA, Handjieva-Darlenska T, Kunesova M, Viguerie N, Langin D, Saris WH, Mariman EC; Diogenes consortium. Int J Obes (Lond). 2012 Dec;36(12):1545-51. doi: 10.1038/ijo.2011.278.

5. A dual epigenomic approach for the search of obesity biomarkers: DNA methylation in relation to diet-induced weight loss. Milagro FI, Campión J, Cordero P, Goyenechea E, Gómez-Uriz AM, Abete I, Zulet MA, Martínez JA.FASEB J. 2011 Apr;25(4):1378-89. doi: 10.1096/fj.10-170365. 

6. Obesity-related polymorphisms and their associations with the ability to regulate fat oxidation in obese Europeans: the NUGENOB study. Corpeleijn E, Petersen L, Holst C, Saris WH, Astrup A, Langin D, MacDonald I, Martinez JA, Oppert JM, Polak J, Pedersen O, Froguel P, Arner P, Sørensen TI, Blaak EE. Obesity (Silver Spring). 2010 Jul;18(7):1369-77. doi: 10.1038/oby.2009.377.

7. TNF-alpha promoter methylation as a predictive biomarker for weight-loss response. Campión J, Milagro FI, Goyenechea E, Martínez JA. Obesity (Silver Spring). 2009 Jun;17(6):1293-7. doi: 10.1038/oby.2008.679.

8. Differential expression of oxidative stress and inflammation related genes in peripheral blood mononuclear cells in response to a low-calorie diet: a nutrigenomics study. Crujeiras AB, Parra D, Milagro FI, Goyenechea E, Larrarte E, Margareto J, Martínez JA. OMICS. 2008 Dec;12(4):251-61. doi: 10.1089/omi.2008.0001.

Cases of success

Generated Patents