Detalle Publicación

ARTÍCULO

Molecular profiling of circulating tumor cells links plasticity to the metastatic process in endometrial cancer.

Autores: Alonso-Alconada,L; Muinelo-Romay,L; Madissoo K,; Diaz-Lopez A,; Krakstad C,; Trovik J,; Wik, E.; Hapangama, D.; Coenegrachts, L; Cano, A; Gil-Moreno A; Chiva de Agustín, Luis; Cueva J, ; Vieito M,; Ortega E, ; Mariscal J, ; Colas E, ; Castellvi J,; Cusido M, ; Dolcet X,; Nijman HW, ; Bosse T, ; Green JA, ; Romano A, ; Reventos J, ; López-López R.; Salvesen HB, ; Amant F, ; Matias-Guiu X, ; Moreno-Bueno ; ENITEC Consortium.
Título de la revista: MOLECULAR CANCER
ISSN: 1476-4598
Volumen: 27
Número: 13
Páginas: 223
Fecha de publicación: 2014
Resumen:
Our results associate the presence of CTC with high-risk EC. Gene-expression profiling characterized a CTC-plasticity phenotype with stemness and EMT features. We finally recapitulated this CTC-phenotype by over-expressing ETV5 in the EC cell line Hec1A and demonstrated an advantage in the promotion of metastasis in an in vivo mouse model of CTC dissemination and homing.
DOI: https://doi.org/10.1186/1476-4598-13-223
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