Ruta de navegación

carrusel-noticia-proyectos

Aplicaciones anidadas

trabajos-fin-master-responsive

Proyectos Fin de máster

Project Nº 01
Title: Validating plasma microRNAs as biomarkers of Alzheimer´s disease: a clinical, neuroimaging and molecular genetic study

Project: Nº 02
Title: Spatial analysis of tissues: cellular positioning and cell-cell interactions in multiplexed histological images

Project: Nº 03 - ASIGNADO
Title: Unraveling the link between epigenetics, RNA transcription and splicing in cancer

Project: Nº 04 - ASIGNADO
Title: Brain Metabolic signatures in primary progressive aphasia variants

Project: Nº 05
Title: GENETIC DRONES: Development of chimeric gene therapy vectors to treat renal diseases

Project: Nº 06
Title: Impact of astrocytic insulin receptor on Alzheimer’s disease

Project: Nº 07
Title: Multimodal study of preclinical synaptic changes in Parkinson’s disease

Project: Nº 08
Title: Development of immunomodulatory nasal therapies in an animal model of progressive parkinsonism

Project: Nº 09 - ASIGNADO
Title: Retromutation and knowdown of SgK496 in lung squamous cell carcinoma (LUSC) cell

Project: Nº 10
Title: Effects of a hypothermic mimetic on neuroinflammation

Project: Nº 11 - ASIGNADO
Title: Bioorthogonal modification of natural polymers for the development of new biomaterials for tissue engineering

Project: Nº 12 - ASIGNADO
Title: What experimental models tell us about the neuroinflammatory reaction that occurs in Parkinson´s disease

Project: Nº 13
Title: Modulation of innate immune response to potentiate lung cancer immunotherapy

Project: Nº 14 - ASIGNADO
Title: Implementation of murine ovarian cancer model based on ID-8 cell line

Project: Nº 15
Title: Diagnostic and therapeutic insights from the analysis of plasma extracellular vesicles in heart failure patients

Project: Nº 16 - ASIGNADO
Title: Identification of novel epigenetic targets and development of new epigenetic inhibitors for the cure of Multiple Myeloma

Project: Nº 17
Title: Development of improved CAR T cells for immunotherapy against Multiple Myeloma

Project: Nº 18 - ASIGNADO
Title: Novel strategies to overcome immunotherapy resistance in NSCLC

Project: Nº 19 - ASIGNADO
Title: Role of YES1 in small cell lung cancer

Project: Nº 20 - ASIGNADO
Title: Metabolic alterations in cancer cells and their implication in immunotherapy

Project: Nº 21
Title: Optimization of cellular and biological treatments by composite fabrication and controlled release from mimetic periosteum scaffolds

Project: Nº 22
Title: Implication of guanylin and uroguanylin in the onset of obesity-associated inflammation: a translational study

Project: Nº 23
Title: Humanization of high-affinity T cell receptors (TCR) developed in nontolerant nonhuman hosts to exploit TCR-therapy targeting shared tumour antigens

Project: Nº 24 - ASIGNADO
Title: Combinatorial Immunotherapies in sarcomas in a novel GEMM platform

Project: Nº 25
Title: RNA aptamers for cancer immunotherapy

Project: Nº 26
Title: The role of the STING pathway in the mechanisms involved in anti-PD-1 treatment resistance in patients with STK11/LKB1 mutant NSCLC

Project: Nº 27
Title: Drug combinations to potentiate the antitumor activity of KRAS inhibitors in cancers with distinct mutational landscape

Project: Nº 28
Title: Role of GDF15 in the development of obesity-associated insulin resistance and type 2 diabetes

Project: Nº 29
Title: Role of interleukin-1b in the infiltration and polarization of macrophages in adipose tissue

Project: Nº 30
Title: Assessment of cerebrovascular reactivity using magnetic resonance imaging

Project: Nº 31
Title: Design, synthesis and biological evaluation of novel selenocompounds as antitumoral agents

Project: Nº 32
Title: Optimization of methods to produce High-Capacity Adenoviral vectors for gene therapy applications

Project: Nº 33
Title: Metabolic profile improvement associated with bariatric surgery

Project: Nº 34
Title: Epigenetic deregulation of endogenous retroviral genes in the origin of human cancers

Project: Nº 35 - ASIGNADO
Title: Understanding the tumor microenvironment of pediatric brain tumors

Project: Nº 36
Title: Armed Oncolytic viruses for the treatment of pediatric brain tumors

Project: Nº 37
Title: Adjuvant treatment with anti-VEGFR3 to improve success of combined radio- and immunotherapy in breast cancer

Project: Nº 39
Title: Synthesis and biological evaluation of new nitric oxide donors as antimicrobial agents

Project: Nº 40
Title: Role of denitrification in Brucella pathogenesis

Project: Nº 41 - ASIGNADO
Title: Emerging Infectious Diseases: Diagnostics/Therapeutics development and assay

Project: Nº 42
Title: Mechanobiology for cardiac regeneration

Project: Nº 43
Title: Biotechnological modification of RNA levels for anticancer RNA vaccines

Project: Nº 44
Title: Role of KLF transcription factors in the pathogenesis of non-alcoholic fatty liver disease pathogenesis and liver cancer.

Project: Nº 45
Title: Role of post-transcriptional modifications (PTMs) in the crosstalk between cholangiocarcinoma and its micro-environment

Project Nº 46
Title: Treatment of intracellular pathogens with tailored and immunomodulatory nanomedicines: an strategy for decreasing risk of antimicrobial resistances

Project: Nº 47
Title: Nanovectors for oncology encapsulating nucleic acid (DNA/RNA)

Project: Nº 48
Title: Development of RNA viral vectors able to express new immunostimulatory molecules for cancer gene therapy

Project: Nº 49
Title: In vitro and in vivo assessment of the myocardial antifibrotic effect of a novel epigenetic regulation inhibitor

Project: Nº 50
Title: Identification of transcriptional lesions guiding aberrant hematopoiesis in myelodysplastic syndromes using single-cell RNA sequencing

Project: Nº 51
Title: Validation of a Microfluidic device for CTCs sorting based on dielectrophoresis forces

Project: Nº 52
Title: Investigating the role of lncRNAs in cancer cell division

Project: Nº 53
Title: HLA-G/ILT4 exosomes as a new target in cancer immunotherapy

Project Nº 01
Title: Role of adipose tissue miRNAs in obesity and weight loss

Project Nº 02
Title: Unraveling the link between epigenetics and RNA splicing in cancer

Project Nº 03
Title: Impact of astrocytic insulin receptor on glucose uptake and cognition

Project Nº 04
Title: GENETIC DRONES: Development of renal gene therapy vectors to treat

Project Nº 05
Title: Implication of guanylin and uroguanylin in the onset of obesity and its associated comorbidities: a translational study

Project Nº 06
Title: Exploring the link between obesity and the risk of dementia

Project Nº 07 ASIGNADO
Title: Enhancing the efficacy of CAR T-cell Therapy for the treatment of solid tumors

Project Nº 08
Title: Novel epigenetic strategies for the treatment of liver tumors

Project Nº 09
Title: Assessment and prevention of chemotherapic-related cardiotoxicity using cell reprogramming and tissue engineering

Project Nº 10
Title: Role of the scavenger receptor MARCO in liver disease: new diagnostic, prognostic and therapeutic strategy

Project Nº 11
Title: Role of miR-506 in the regulation of the liver- and immunophenotype in primary biliary cholangitis

Project Nº 12 ASIGNADO
Title: Understanding mechanims of synergy in CD137-based cancer immunotherapy

Project Nº 13
Title: Role of interleukin-1B in the infiltration and polarization of macrophages in adipose tissue

Project Nº 14 ASIGNADO
Title: Mechanisms and antileukemic efficacy of combined therapies based on the functional activation of PP2A in acute myeloid leukemia. Role of PP2A regulatory subunits as specific targets

Project Nº 15
Title: Role of GDF15 in the development of obesity-associated insulin resistance and type 2 diabetes

Project Nº 16
Title: Development of new therapeutic alternatives against HDV infection based on RNA editing strategies

Project Nº 17
Title: Design, synthesis and biological evaluation of novel selenides as antitumoral agents

Project Nº 18
Title: New approaches of CAR-T therapy against the tumour microenvironment

Project Nº 19
Title: Unfolded protein response and myocardial fibrosis in heart failure

Project Nº 20
Title: Improving CART cell therapies for hematological malignances: from innovative CAR designs to modulation of molecular mechanisms

Project Nº 21 ASIGNADO
Title: Role of the autocrine IL-10/STAT3 cascade in the pro-survival signalling and anti-tumour immune evasion of diffuse large B-cell lymphomas

Project Nº 22
Title: Effect of Sirtuin2 inhibition in a transgenic mouse model of Alzheimer disease

Project Nº 23 ASIGNADO
Title: Development of new epigenetic inhibitors for the cure of Multiple Myeloma

Project Nº 24
Title: Understanding Tumor Initiation using 3D organoid models, microfluidics and advanced three-dimensional microscopy

Project Nº 25 ASIGNADO
Title: Translational biomarkers for the evaluation of physical/pharmacological neuromodulation strategies

Project Nº 26
Title: Amylin as a therapeutic target in Parkinson's disease

Project Nº 27
Title: New antigen targets for vaccination in hepatocellular carcinoma: identification of T cell epitopes from micropeptides derived from long non-coding RNAs

Project Nº 28_ASIGNADO
Title: Resting-state fMRI in presurgical mapping

Project Nº 29
Title: Riboswitches for therapeutic expression

Project Nº 30
Title: Nonsense Mediated mRNA Decay (NMD) as an antigen immune-checkpoint

Project Nº 31
Title: Contribution of altered transcrtiptional regulators to the phenotype of Myelodysplastic Syndromes and Acute Myeloid Leukemia

Project Nº 32
Title: Brain Metabolic signatures in primary progressive aphasia variants

Project Nº 33
Title: Effects of a hypothermic mimetic on brain insulin pathway

Project Nº 34
Title: Biofabrication of a human Achilles tendon

Project Nº 35
Title: Study of the early synaptic changes in Parkinson’s disease

Project Nº 36
Title: Optimization of brain biodistribution of high-capacity adenoviral vectors

Project Nº 37
Title: Optimization of rhBMP-2 treatments by composite fabrication and controlled release from mimetic periosteum scaffold

Project Nº 38
Title: New therapeutic combinations against KRAS-driven non-small cell lung cancer (NSCLC). Study of new biomarkers of response to anti-PD-1 therapy

Project Nº 39
Title: In vitro and in vivo assessment of the myocardial antifibrotic effect of a novel epigenetic regulation inhibitor

Project Nº 40
Title: Investigating the role of lncRNAs in cancer cell division

Project Nº 41
Title: A genome-wide approach to discover small circular RNAs under physiological and stress conditions

Project Nº 42 ASIGNADO
Title: Characterization of the role of DYSTYK, a dual serine/threonine tyrosine kinase and in non-small cell lung cancer

Project Nº 43
Title: Deciphering the role of PRDM1 in adipose tissue transcriptome and obesity susceptibility

Project Nº 44
Title: Metabolic profile improvement associated with bariatric surgery

Project Nº 45
Title: Design of nanoparticles for the local treatment of cutaneous leishmaniasis

Project Nº 46
Title: Development of a hydrogel containing a novel diselenide for the topical treatment of localized cutaneous leishmaniasis

Project Nº 47
Title: Development of novel strategies to potentiate lung cancer immunotherapy

Project Nº 48
Title: Anti-drug-antibodies (ADA) as a mechanism of acquired resistance in cancer immunotherapy

Project Nº 49
Title: Identificantion of candidate genes conferring resistance to dementia in the context of Alzheimer´s Disease

Project Nº 50  ASIGNADO
Title: Molecular and cellular mechanisms underlying Amyotrophic Lateral Sclerosis

Project Nº 51
Title: Clinical Utility of a Comprehensive Next-Generation Sequencing Panel for Hereditary Cancer Syndromes

Project Nº 52
Title: Protein-based nanoparticles for the delivery of bevacizumab

Project Nº 53
Title: Transcriptomic analysis (RNAseq) of endothelial extracellular vesicles (EndEVs) in patients with cardiovascular diseases

Project Nº 54
Title: Characterization of the role of PRDM1 and CDK2 in lipid and glucose metabolism in cultured adipocytes

Project Nº 55
Title Adjuvant treatment with anti-VEGFR3 to improve success of immunotherapy in breast cancer

Project Nº 56 ASIGNADO
Title: From single molecule mRNA visualization in living cells to genetic and proteomic screens: Discovering the composition of transport of the XBP1 ribonucleoprotein  

Project Nº 57 ASIGNADO
Title: Genetically engineered mouse models by Crispr/cas9 genome editing for the screening of cutting-edge immunotherapies

Project Nº1 - ASIGNADO
Title: GENETIC DRONES: Development of renal gene therapy vectors

Project Nº2
Title: Next-generation immune monitoring in multiple myeloma

Project Nº3
Title: Development of novel engineered forms of fibroblast growth factor 21 (FGF21) for the treatment of metabolic syndrome-associated diseases

Project Nº4
Title: Translational biomarkers for the evaluation of physical/pharmacological neuromodulation strategies

Project Nº5
Title: Role of clonal hematopoiesis of indeterminate potential (CHIP) in the pathogenesis and evolution of chronic pulmonary diseases

Project Nº6 - ASIGNADO
Title: Design, synthesis and application of novel biorthogonal hydrogels for cardiac tissue engineering

Project Nº7
Title: Role of GDF15 in the development of obesity-associated insulin resistance and type 2 diabetes

Project Nº8
Title: Role of Cxcl12 in bone regeneration 

Project Nº9
Title: Cell competition as a strategy tro increase interspecies chimerism

Project Nº10
Title: Coupling epigenetics and RNA splicing in cancer

Project Nº11 - ASIGNADO
Title: Neuroinflamation in the alpha‐synuclein models of Parkinson´s disease

Project Nº12
Title: Optimization of gene transfer strategies for brain diseases

Project Nº13
Title: Study of the implication of an oncogenic domain in cell biology of primitive eukaryotic cells

Project Nº14
Title: Role of the mutagenic enzyme AID in the pathogenesis of B-cell lymphomas

Project Nº15
Title: Treatment of hepatocellular carcinoma by targeting the non-coding genome

Project Nº16
Title: Resting state brain networks in mild cognitive impairment and Alzheimer’s disease

Project Nº17 - ASIGNADO
Title: Impact of astrocytic insulin receptor on cognition

Project Nº18
Title: Role of the scavenger receptor MARCO in liver cancer: new diagnostic, prognostic and therapeutic strategy

Project Nº19
Title: Immunogenicity of neoantigens in hepatocellular carcinoma

Project Nº20
Title: Modulation of innate immnune response to potentiate lung cancer immunotherapy

Project Nº21 - ASIGNADO
Title: Elucidating the Mechanism of HDV-induced liver damage

Project Nº22
Title: Design, synthesis and biological evaluation of novel selenides as antitumoral agents

Project Nº23
Title: Mechanisms of long-term CART cell persistence for improved therapeutic efficacy

Project Nº24
Title: Designing nanomedicines for the targeting and activation of Leishmania spp. infected macrophages

Project Nº25
Title: New immunomodulatory combinations against lung adenocarcinoma (LUAD) according to the mutational status of KRAS oncogene. Study of new biomarkers of response to anti-PD-1 therapy

Project Nº26
Title: Role of post-transcriptional modifications (PTMs) in the etiopathogenesis of cholangiocarcinoma: new diagnostic, prognostic and therapeutic strategy

Project Nº27
Title: Impact of thrombus composition on neurovascular damage in ischemic stroke

Project Nº28
Title: Correlate tumor mutation burden with immune signatures and clonality of T cell receptors in human cancers

Project Nº29
Title: Dechipering the role of specific transcriptional regulators in cardiovascular progenitors derived from human iPSCs

Project Nº30
Title: New approaches of adoptive transfer cell therapy for cancer immunotherapy

Project Nº31
Title: Effect of the activation of key molecules for the survival and metabolic fitness of T cells to enhance their antitumor efficacy

Project Nº32
Title: Histological characterization of a diet-induced obese zebrafish (Danio rerio) model   

Project Nº33 - ASIGNADO
Title: Development of new combined therapies in acute myeloid leukemia. Towards a personalized treatment in patients with mutations in the FLT3 tyrosine kinase receptor and overexpression of the SET oncoprotein

Project Nº34
Title: Effects of a high fat diet on adrenomedullin KO mice

Project Nº35
Title: Interplay of adipokines and myokines after bariatric surgery: a translational study

Project Nº36
Title: Identification of tumor exosomes from humanized-Patient-Derived-Xenograft (PDX) model

Project Nº37
Title: Functional changes of the synapse in the beginning and progression of the dopaminergic death

Project Nº38
Title: Metabolic changes associated with bariatric surgery

Project Nº39 - ASIGNADO
Title: Study of molecular mechanisms underlying neurodegenerative diseases like Parkinson's disease  to identify effective therapeutic targets 

Project Nº40
Title: Study of molecular mechanisms underlying neurodegenerative diseases like Parkinson's disease  to identify effective therapeutic targets 

Project Nº41
Title: Cancer Immunotherapy using immunostimulatory aptamers

Project Nº42
Title: Role of adipose tissue miRNAs in obesity and weight loss

Project Nº43
Title: Study of the mechanism of lncRNA function in cancer cells

Project Nº44
Title: EXOSOMES, miRNAs AND LIVER STEATOSIS: DIAGNOSIS AND TARGET GENES

Project Nº45
Title: Adipose tissue, macrophages and immunomodulation. Role of interleukin-1 in infiltration and polarization of macrophages in adipose tissue

Project Nº 46
Title: A genome-wide approach to discover small circular RNAs under physiological and stress conditions

Project Nº 47
Title: Mucus-permeating nanoparticles as carriers for oral delivery of therapeutic proteins  

Project Nº 48
Title: Study of the molecular mechanisms involved in fibroblasts activation and differentiation in Myocardial Infarction

Project Nº 49
Title: GAS6/PROS-TAM pathway inhibition to enhance immune response in T cells-based immunotherapy

Project Nº 50 - ASIGNADO
Title: Intestinal absorptionof transition metals

Project Nº 51 - ASIGNADO
Title: EFFECT OF NADPH OXIDASE 5-MEDIATED OXIDATIVE STRESS ON MATRIX METALLOPROTEINASES

Project Nº 52 - ASIGNADO
Title: Exploring mTOR pathway in the brain and peripheral tissues of p27 KO mice: effect on memory and modulation by high fat diet

Project Nº 53 - ASIGNADO
Title: Enhancing matrix integration and mechanical properties of tissue-engineered cartilage

Project Nº 54 - 
Title: Theranostics of Neuroendocrine Tumors: the role of peptide receptor radionuclides targeting somatostatine receptors

Project Nº55
Title: The added value of Trabecular Bone Score to DXA for fracture prediction in liver transplant patients

Project Nº56
Title: Molecular characterization of Brucella strains

Project Nº 57
Title: Understanding tumor plasticity and non-genetic drug resistance mechanisms of BRAF mutant melanoma 

Project Nº 58 - ASIGNADO
Title:  Enhancing matrix integration and mechanical properties of tissue-engineered cartilage 

Project Nº1
Title: Role of clonal hematopoiesis of indeterminate potential (CHIP) in the pathogenesis and evolution of chronic pulmonary diseases

Project Nº2
Title: Role of SLU7 controlling splicing and DNA methylation in cancer

Project Nº3
Title: Tumor immunity modulation with aptamer siRNA chimeras_new ways to enhance tumor antigenicity

Project Nº4
Title: Mechanism of fracture nonunion

Project Nº5
Title: Antibiotic free injectable biomaterial coating to prevent implant-associated infections

Project Nº6
Title: Unraveling the pathogenesis of human multiple myeloma by integrative multi-OMICS and single-cell RNA-seq studies in transgenic mouse models

Project Nº7
Title: Role of the transcription factor KLF15 in the etiopathogenesis of cholangiocarcinoma_new diagnostic, prognostic and therapeutic strategy

Project Nº8
Title: Role of the scavenger receptor MARCO in liver disease_new diagnostic, prognostic and therapeutic strategy

Project Nº9
Title: Impact of thrombus composition on neurovascular damage in ischemic stroke

Project Nº10
Title: Understanding the Molecular Insights of Primary Hyperoxaluria_Disease Models, Regulators and Modifiers

Project Nº11
Title: Neuroinflammation and classical activation vs alternative activation of microglia in Alzheimers disease_the good_the bad and the ugly

Project Nº12
Title: Novel 3D hydrogel-hybrid systems in cardiac tissue engineering with human induced pluripotent stem cells

Project Nº13
Title: mRNA based cancer immunotherapy with mutifuntional nanoscafolds

Project Nº14
Title: Improvement of gene therapy vectors for treatment of metabolic rare diseases

Project Nº15
Title: Interplay of adipokines and myokines after bariatric surgery_a translational study

Project Nº16
Title: In situ vaccination to enhance the efficacy of current antitumor immunotherapy

Project Nº17
Title: Do Inflammatory Polyps display Immune Context Associated with the Early Stages of Malignant Progression

Project Nº18
Title: Enhancing the efficacy of CAR T-cell Therapy for the treatment of solid tumors

Project Nº19
Title: Innovative differentiating epigenetic therapy for the cure of Acute Myeloid Leukemia

Project Nº20
Title: Study of the mechanism of lncRNA function in cancer cells

Project Nº21
Title: Alpha-synuclein mechanisms of neurodegeneration

Project Nº22
Title: Study of the implication of an oncogenic domain in cell biology of primitive eukaryotic cells

Project Nº23
Title: Study of target molecules in cardiac fibrosis and development of therapeutic nanoparticles for its treatment

Project Nº24
Title: Overexpression of mutated tau in the brain of APPPS1 mice using adenoassociated virus (AAV) as a preclinical model of Alzheimer

Project Nº25
Title: Modulation of the innate immune response to potentiate the antitumor activity of immunotherapy against lung cancer

Project Nº26
Title: Collagen cross-linking in heart failure, a new central player in cardiac dysfunction

Project Nº27
Title: Characterization of T regulatory inhibitors for Immunomodulation in anti-tumour treatments

Project Nº28
Title: Virulence factors in E. coli resistant bacteria

Project Nº29
Title: Exploring the tumor microenvironment and novel immunotherapy strategies in pre-clinical mouse models of B cell lymphomas

Project Nº30
Title: Designing nanomedicines for the targeting and activation of Leishmania spp. infected macrophages

Project Nº31
Title: Diseño, síntesis y evaluación biológica de nuevos seleniuros asimétricos como agentes antitumorales

Project Nº32
Title: Role of the interleukin-1 receptor antagonist in the development of obesity-associated insulin resistance and fatty liver

Project Nº33
Title: Cinematic and neuroimaging study of gait in aging and Parkinson s disease

Project Nº34
Title: Translational biomarkers for the evaluation of physical-pharmacological neuromodulation strategies

Project Nº35
Title: Humanised-mouse models to implement immunotherapy of cancer

Project Nº36
Title: 3D printing to bioengineer the hematopoietic stem cell niche

Project Nº37
Title: RNA sequencing for the characterization of glial cell activity

Project Nº38
Title: Inhibitory strategies to target key effectors in epithelial tumors driven by the KRAS oncogene

Project Nº39 - ASIGNADO
Title: Cancer Gene Therapy based on local expression of immunostimulatory genes

Project Nº40 - ASIGNADO
Title: The primary cilium in brain tumor progression and therapeutics

Project Nº41 - ASIGNADO
Title: New insights into the molecular pathogenesis of CALR-mutated myeloproliferative neoplasms using a Caenorhabditis elegans model

Project Nº42 - ASIGNADO
Title: Small RNAs and the Unfolded Protein Response_Development of a method to identify small circular RNAs

Project Nº43 - ASIGNADO
Title: Preclinical development of systemic delivery of PBGD messenger RNA as an etiological treatment for acute intermittent porphyria.

Project Nº44 - ASIGNADO
Title: Improvement of brucellosis diagnsostic tools

Project Nº45
Title: Age related clonal hematopoiesis role in thrombotic cardiovascular disease

Project Nº 46 - ASIGNADO
Title: Modulation of the Unfolded Protein Response in Motoneurons: A new Gene Therapy for Acute Lateral Sclerosis? 

Project Nº 47 - ASIGNADO
Title: Analysis of transcriptional profile in patients with Acute Myeloblastic Leukemia as a tool for prognoses and target identification 

Project Nº 48
Title: Antitumor activity of ID1, MEK1/2 and PD-1 combined blockade in a kras-driven non-small cell lung cancer model

Project Nº 49 - ASIGNADO
Title: Challenges in the detection of clinically-relevant mutations in ABL1 gene in patients with Chronic Myeloid Leukemia. Evolution of technology, needs and new solutions.

Project Nº 50 - ASIGNADO
Title: Understanding the cellular and molecular layers of organization that define the stem cell niche at a single cell resolution

 

Project Nº 1
Title: Gene therapy with glucocerebrosidase for the treatment of misfolded neurodegenerative proteinopathies

Project Nº 2
Title: NMD as an endogenous mechanism to modulate tumour immunity

Project Nº  3 ASIGNADO
Title: Improvement of gene therapy vectors for neonatal treatment of metabolic rare diseases

Project Nº  4
Title: Functional characterization of constitutive B-cell receptor (BCR) and MYD88 signaling activation in lymphomagenesis 

Project Nº  5
Title: Dissection of new targets to block loco-regional failure post-brachytherapy

Project Nº  6
Title: Genocopy models of lung cancer metastasis for targeted therapies

Project Nº  7
Title: Mechanical stimulation of human induced pluripotent stem cell-based engineered cardiac tissues

Project Nº  8
Title: Functional analysis of noncoding RNAs involved in the proliferation of hepatocellular carcinoma: from basic research to clinical application 

Project Nº  9
Title: Potential of in vivo gene editing by CRISPR/Cas for the treatment and modelling of rare diseases.

Project Nº 10      
Title: Detection of non-coding rearrangements in Multiple Myeloma

Project Nº  11
Title: Study of the mechanisms underlying liver regeneration using proteomics 

Project Nº  12 ASIGNADO
Title: The zebrafish homologs of PP2A regulatory subunits: expression patterns and insights into their physiological roles during development

Project Nº  13
Title: Study of biodistribution of NP in Leishmania spp infected mice by Near-IR and bioluminescence imaging.

Project Nº  14
Title: In vivo Designing nanoparticles for the activation of Leishmania spp. infected macrophages

Project Nº  15
Title: A murine immune competent model of hepatocellular carcinoma to develop immunotherapeutic strategies

Project Nº  16 ASIGNADO
Title: DEVELOPMENT OF IN VITRO AND IN VIVO MODELS TO STDY METASTASIS IN SQUAMOUS CARCINOMAS OF THE LUNG

Project Nº  17 ASIGNADO
Title: Exploring molecular mechanisms of germinal center-derived lymphomagenesis

Project Nº  18
Title: Study of the crosstalk of adipokines and myokines in the onset of obesity and its associated comorbidities

Project Nº 19
Title: Immunovirotherapy for the treatment of pediatric solid tumors

Project Nº 20
Title: Development and validation of a lentiviral library for CRISPR-Cas9-based screening of the human miRNome role in cell biology

Project Nº  21
Title: Investigating the dark matter of the cancer genome 

Project Nº  22
Title: Role of insulin resistance in Alzheimer´s disease

Project Nº  23
Title: Study of the epigenetic mechanisms involved in fibroblasts activation in Myocardial Infarction 

Project Nº 24
Title: Gold nanoparticles as biomarkers and its possible therapeutic applicability in retinal models of disease

Project Nº  25
Title: Molecular characterization of Listeria monocytogenes strains from clinical isolates.

Project Nº  26
Title: Adipose tissue, macrophages and immunomodulation. Role of interleukin-1 in infiltration and polarization of macrophages in adipose tissue.

Project Nº  27
Title: Engineering T-cells with retrovirus vectors able to express an immunomodulatory antibody for cancer therapy 

Project Nº  28
Title: Role of the interleukin-1 axis in the osteopontin-mediated development of insulin resistance in the context of obesity.

Project Nº  29 ASIGNADO
Title:  Analysis of brain-heart-respiratory coupling in REM sleep behavioral disorder (RBD)

Project Nº  30 ASIGNADO
Title: Circuit-specific manipulations for psychiatric and neurodevelopmental diseases

Project Nº  31
Title: Cell cycle and metabolism: who regulates whom?: Role of Cdk2 in adipose tissue (ADIPOCLYN)

Project Nº 32
Title: Gene correction for inborn errors of metabolism

Project Nº  33
Title: Characterization of the therapeutic potential of the lipid mediator Maresin 1 on obesity-induced cognitive decline during aging

Project Nº  34
Title: Resting state brain networks in mild cognitive impairment

Project Nº  35
Title: Stereological estimations of serotonergic, GABAergic and glutamatergic cells in the different subfields of the dorsal raphe nucleus in control mice

Project Nº  36 ASIGNADO
Title: Assessment of neurovascular uncoupling in brain tumors using magnetic resonance imaging (MRI) 

Project Nº  37
Title: Inhibitory strategies to target key effectors in epithelial tumors driven by the KRAS oncogene

Project Nº 38
Title: Evaluation of choroidal neovascularisation lesions in rats transplanted with non-viral transfected IPE and RPE cells for long-term PEDF release

Project Nº 39 ASIGNADO
Title: Search for metagenomic markers in relation to weight loss

Project Nº 40
Title: Strategies of transient gene engineering with mRNA of antitumor T-cells

Project Nº 1
Title: The primary cilium in brain tumor progression and therapeutics.

Project Nº 2
Title: Preclinical evaluation of anti-PD-L1 in combination with lenalidomide for the treatment of leukemia, lymphoma and myeloma

Project Nº 3 ASIGNADO
Title: Emerging therapies for acute intermittent porphyria.

Project Nº 4
Title: Therapeutic effect of a combined strategy to block PD-1 and Id1 in a murine model of lung cancer

Project Nº 5
Title: Inmuno-Oncology in Brain Cancer: Study of a dual mechanism of inhibition of immune response associated to both CD8/PD-1/PDL1 and anti-inflammatory M2 macrophage in glioblastoma.

Project Nº 6
Title: Innovative therapeutic approaches for rare diseases by in vivo CRISPR/Cas gene editing.

Project Nº 7
Title: Exploiting a new target for cancer immunotherapy

Project Nº 8 ASIGNADO
Title:  Functional elucidation of the role of KRAS oncogene effectors in epithelial cancers

Project Nº 9
Title: Inducing tolerance against AAV to improve their therapeutic use in gene therapy

Project Nº 10
Title: Comparative study of the different clinical trials of anti-VEGF treatments of neovascular Age-Related Macular Degeneration (nAMD)

Project Nº 11 ASIGNADO
Title: Development of new therapeutic strategies for inherited liver metabolic disorders. Gene therapy and genetic corrections

Project Nº 12
Title: New therapeutic targets for the treatment of myocardial fibrosis in heart failure patients

Project Nº 13
Title: New players in the development of myocardial fibrosis in chronic heart failure. Potential therapeutic applications of the PCP/PCPE-1-LOX axis.

Project Nº 14
Title: Visuospatial Integration in Vehicle Driving, Age Related Changes and Rehabilitation Potential. An fMRI and Virtual Simulation Study

Project Nº 15 ASIGNADO
Title: Screening of dopamine D1/D2 receptor heteromers in the striatum of the long-tailed macaque. Changes following dopaminergic manipulation.

Project Nº 16
Title: Therapeutic development based in the inhibition of noncoding genes involved in the progression of hepatocellular carcinoma 

Project Nº 17
Title: Polymicrobial biofilm growth kinetics. In vitro susceptibility to antimicrobial agents.

Project Nº 18
Title: Oral administration of encapsulated insulin: Possible treatment for Alzheimer’s disease?

Project Nº 19
Title: Gut microbiota composition can influence body weight loss by interacting with diet composition

Project Nº 20
Title: Role of the NADPH oxidase 5 in vascular and metabolic complications in experimental obesity

Project Nº 21 ASIGNADO
Title: Stimulation of central nervous system through the olfactory system as a method to improve antiviral and antitumoral immune response

Project Nº 23
Title: Deletion of endothelial metalloproteinase-10 by CRISPR/Cas9 genome editing and analysis of functional effects 

Project Nº 24
Title: Role of osteopontin in colon cancer development in the context of obesity.

Project Nº 25
Title: Characterization of new hepatoprotective chimeric proteins based on fibroblast growth factor 19 (FGF19) and amphiregulin (AR) as therapeutic tools for the treatment of acute liver failure.

Project Nº 26
Title: Molecular mechanisms of neurodegeneration; role of the unfolded protein response (UPR).

Project Nº 27
Title: Study of the tumoral exosomes as inducer of myeloid-derived suppressor cells and messengers transporting immunosuppressive molecules

Project Nº 28
Title: Study of the mechanisms involved in fibroblasts activation in Myocardial Infarction and development of new nanotechnological therapeutic strategies

Project Nº 29
Title: Characterization of small-colony variants of Staphylococcus in patients with chronic infections.

Project Nº 30
Title: Molecular mechanism for fracture nonunion and its treatment through the optimization of mimetic autografts

Project Nº 31 ASIGNADO
Title: Study of resistance and virulence gene transfer among Enterobacteriaceae Extended-Spectrum β-lactamases (ESBL) producers.

Project Nº 32 ASIGNADO
Title: Roles of juvenile NMDA receptors containing juvenile GluN3A subunits in anxiety, stress and social behaviors: Implication of the oxytocin/vasopressin balance?

Project Nº 33
Title: Genocopy models of lung cancer metastasis for targeted therapies

Project Nº 34
Title: Stereological estimates of  GABA-A receptor gamma 2 subunit-immunoreactive neurons in the pedunculopontine and laterodorsal tegmental nuclei in the rat

Project Nº 35
Title: Development of viral vectors able to express immunomodulatory antibodies for cancer gene therapy

Project Nº 36
Title: HIV-1 molecular epidemiology from newly diagnosed adult patients in Kinshasa: prevalence of subtypes and resistance mutations to antiretrovirals.

Project Nº 37 ASIGNADO
Title: Role of endothelins in the pathophysiology of polycystic liver diseases (PLDs)

Project Nº 38
Title: Study of the crosstalk of adipokines and myokines in the onset of obesity and its associated comorbidities

Project Nº 39
Title: Horizontal gene transfer (HGT) and cancer development, exogenous BRCT from pathogens may induce human cell malignancy

Project Nº 40
Title: Dissection of new targets to block loco-regional failure post-brachytherapy

Project Nº 41
Title: How cells cope with stress: Study of the transport of XBP1 mRNA to ER stress response centers.

Project Nº 42
Title: Role of oxidative stress in myocardial fibrosis in heart failure

Project Nº 43
Title: Adipose tissue, macrophages and immunomodulation. Role of interleukin-1 in infiltration and polarization of macrophages in adipose tissue.

Project Nº 44
Title: ADIPOCLYN. Cell cycle and metabolism: who regulates whom? Control of adipocyte metabolism by CDK and cyclins.

Project Nº 45
Title: Effects of an omega-3 derived proresolving lipid mediator on gut microbiota composition and its association with intestinal inflammation and insulin sensitivity in an animal model of obesity.

Project Nº 47 ASIGNADO
Title: The SET oncoprotein as a therapeutic target in acute myeloid leukemia. 

Project Nº 48 ASIGNADO
Title:Therapeutic potential of induced cardiovascular progenitors in models of myocardial infarction

Project Nº 49
Title: Assessment of atrophy and white matter lesion burden using magnetic resonance imaging (MRI) in people with subjective memory complaints, as possible biomarkers of Alzheimer's disease.

Project Nº 50
Title: In vivo evaluation of resting state neural networks in Parkinson's disease using Magnetic Resonance Imaging

Project Nº 51
Title: Hemispheric dominance of Parkinson's disease and cognitive function

Project Nº 52
Title: New therapeutic strategies for Alzheimer's disease based on enhancing synaptic plasticity

Project Nº 53
Title: Antimicrobial peptides to control biofilms associated with medical impalnts

Project nº 1 ASIGNADO
Title: Optimizing cáncer immunotherapy: stimulation of T cell migration across lymphatic vessels

Project nº 2
Title: Role of amphiregulin in liver metabolism

Project nº 3
Title: Production and application of High‐Capacity adenoviral vectors in the treatment of gastrointestinal cancers

Project nº 4
Title: Role of insulin resistance in Alzheimer´s disease

Project nº 5
Title: In vivo evaluation of resting state neural networks in Parkinson's disease using Magnetic Resonance Imaging

Project nº 6
Title: Role of the splicing factor Slu7 in liver pathophysiology

Project nº 7
Title: New therapeutic targets for the treatment of fibrosis in myocardial infarction

Project nº 8
Title: Adipose tissue, macrophages and immunomodulation: Role of interleukin‐32 in infiltration and polarization of macrophages in adipose tissue

Project nº 9
Title: Does MMP‐10 play a role in cardiac repair after ischemia?

Project nº 10
Title: Dissecting the functional role of dominant oncogene effectors in epithelial cancers

Project nº 11
Title: Pharmacological modulation of histone acetylation and methylation in PTEN haploinsufficient and heterogeneous glioblastoma

Project nº 12
Title: Development of viral vectors able to express immunomodulatory antibodies for cancer gene therapy

Project nº 13
Title: Identification of long noncoding RNAs involved in the progression of hepatocellular carcinoma

Project nº 14
Title: Blockade of immunoregulatory molecules in dendritic cells to improve antitumor vaccine efficacy

Project nº 15
Title: Neuroinflammation and classical activation vs alternative activation of microglia in Alzheimer's disease: the good, the bad and the ugly?

Project nº 16
Title: Adoptive Immunotherapy of Cancer with Tumor‐infiltrating T Lymphocytes (ACT‐TIL): selection of tumor‐specific T cells to enhance their therapeutic effectiveness

Project nº 17
Title: MicroRNAs as regulators of energy homeostasis in obesity

Project nº 18 ASIGNADO
Title: Alpha synuclein‐dependent mechanisms of neurodegeneration

Project nº 19
Title: Role of lncRNAs in cancer epigenetics

Project nº 20
Title: Development of a gene therapy treatment for Gene Therapy for a rare disease Progressive familial intrahepatic cholestasis (PFIC)

Project nº 21
Title: How cells respond to (endoplasmic reticulum) stress: Study of the transport of XBP1 mRNA

Project nº 22
Title: Development of new treatments for chronic hepatitis delta infection

Project nº 23
Title: HIV Voluntary counseling and testing in Kinshasa: Sexual behaviors and prevalence of subtypes and resistance mutations to antiretrovirals

Project nº 24
Title: In vivo validation of NatB as a new antitumoral target

Project nº 25
Title: Role of complement system in lung carcinogenesis

Project nº 26
Title: Study of the coordinated regulation of aquaglyceroporins in insulin‐sensitive tissues in obesity and type 2 diabetes

Project nº 27
Title: Characterization of Key Epigenetic Targets in Hepatic Fibrosis and Hepatocellular Carcinoma Development. Generation of New Antifibrotic and Antitumoral Drugs

Project nº 28
Title: Inhibition of T regulatory cell activity as a therapeutic strategy against cancer

Project nº 29
Title: Genocopy models of lung cancer metastasis for targeted therapies

Project nº 30
Title: Immunotherapy in brain cancer. Characterization of the immune intratumoral infiltration and clinical correlations

Project nº 31
Title: Cytogenetic and Molecular Cytogenetic Characterization of Pancreatic Cancer

Project nº 32
Title: New immunostimulatory nanoparticle for cancer immunotherapy

Project nº 33
Title: Stabilization and cerebral and hepatic localizations of a fusion protein of the aminolevulinate dehydratase for early treatment of acute attacks in hepatic porphyrias

Project nº 34
Title: Health implications of sterols´ oxidation products and factors involved in their formation

Project nº 35
Title: Identification and validation of targets to develop new therapies to stop the progession of AD: epigenetic and non‐epigenetic targets

Project nº 36
Title: New players in the development of myocardial fibrosis in chronic heart failure. Potential therapeutic applications of the PCP/PCPE‐1‐LOX axis.

Project nº 37
Title: Diseño, síntesis y evaluación biológica de nuevos seleniuros asimétricos como agentes antitumorales

Project nº 38
Title: Role of genetic manipulations of GluN3A‐containing NMDA receptors in depression using a model of chronic stress

Project nº 39
Title: New therapeutic strategies for Alzheimer´s disease based on enhancing synaptic plasticity

Project nº 40 ASIGNADO
Title: Characterization of microglia activation in parkinsonian mice

Project nº 41
Title: Transcriptional regulation of adipose tissue metabolism in obesity, inflammation and insulin resistance: effects of omega‐3 and derived specialized proresolving lipid mediators

Project nº 42
Title: Understanding how homeobox protein NKX2‐3 Triggers B‐Cell receptor signaling and promotes marginal‐zone lymphomagenesis

Project nº 43
Title: Regulation of serotonin (5‐HT) function by a VGLUT1 dependent glutamate pathway

Project nº 44
Title: Study Of Fine Behavioural Parameters in Central Nervous System Rodent Models

Project nº 45
Title: Effect of Deep Brain Stimulation on the Neural Activity of the Primary Motor Cortex

Project nº 47
Title: Mechanistic analysis of two new anti‐fibrinolytic compounds

Project nº 48 ASIGNADO
Title: Role of TREM2 receptor in acute and chronic liver injury

Project nº 49 ASIGNADO
Title: Role of the metastatic protein TMPRSS4 in lung and breast cancer. Novel strategies for its inhibition

Project nº 50 ASIGNADO
Title: Targeting Ovarian Cancer Tumors with Aptamer decorated DANPs

Project nº 51
Title: Impact of an integral intervention in children with risk of diabetes in Navarra: genetic and epigenetic markers study

Project nº 52
Title: Study of inflammation and dopaminergic degeneration in a model of progressive parkinsonism

Project nº 54
Title: Role of the NADPH oxidase 5 in vascular and metabolic complications in experimental obesity

Project nº 55
Title: Development of new approaches for multiplex amplification of gene targets

Project nº 56
Title: Study and Characterization of a newly discovered oncogenic domain in leishmania spp

Para la realización del trabajo fin de máster en el extranjero el alumno deberá acreditar un nivel avanzado de inglés o el del idioma del país del centro de realización del trabajo fin de master. 

La incorporación del alumno a la institución o empresa nacional o internacional está sujeta a la aceptación por parte del centro que se haya escogido para la realización del TFM.

Asignación de Trabajo Fin de Máster para el curso 2021-2022
Los alumnos que no tengan un proyecto ASIGNADO, deben seleccionar dos de los proyectos publicados y comunicar mediante el envío de un email a masterfciencias@unav.es, su elección por orden de preferencia. La fecha límite para la elección es el 30 de agosto de 2021.  No se podrán por tanto escoger proyectos que figuren como ASIGNADOS.

Por otro lado, los alumnos que tengan el proyecto ASIGNADO, deberán comunicar también cuál es su trabajo fin de máster.

Dado el número limitado de proyectos no es posible garantizar en todos los casos que el proyecto seleccionado como primera opción sea el asignado. En caso concurrencia de varios candidatos a un mismo proyecto como primera opción, la adjudicación del proyecto se realizará en base al expediente académico de los candidatos y su curriculum vitae.

La Comisión Académica del Máster valorará los proyectos seleccionados por los alumnos y se comunicará no más tarde de la segunda semana de septiembre de 2021, cuál es el proyecto que se le ha asignado.

Una vez asignado el Trabajo Fin de Máster y comenzado el curso, no se podrá realizar cambio de proyecto en ningún caso.