News

Imagen subrayado titulo

30/04/2020

Belén Perez Solans and María García Cremades

Our former PhD students Belén Perez Solans and María García Cremades, currently at the University of California San Francisco (UCSF), have built a mechanistic pharmacokinetic/pharmacodynamic/toxicodynamic model to predict the effect of hydroxychloroquine in humans based on in vitro data. This work is entitled: Optimizing Hydroxychloroquine Dosing for Patients With COVID‐19: An Integrative Modeling Approach for Effective Drug Repurposing and it has been published in Clinical Pharmacology & Therapeutics.

 

..................................

14/02/2020

Our Postdoctoral researcher Violeta Balbas-Martinez has been nominated as Journal of Pharmacology and Experimental Therapeutics Highlighted Trainee Author for the March 2020 issue. Violeta was working as a pre-doctoral trainee at our group at the time the manuscript was accepted. The JPET article that earned her selection as a Highlighted Trainee Author is titled “A Quantitative Systems Pharmacology model for the key Interleukins involved in Crohn's Disease” and is available at https://doi.org/10.1124/jpet.119.260539.

Website

..................................

  • News 2019

    13/12/2019

    Violeta Balbas-MartínezOur PhD student Violeta Balbas-Martinez defended her thesis entitled “Towards Mechanistic Characterization of Inflammatory Bowel Disease and complicated Urinary Tract Infection using Systems Pharmacology Approaches”. This work has been done under the supervision of Prof. Iñaki F. Trocóniz.

     

     

     

     

    ..................................

    20/11/19

    Our group members Maria Jesús Garrido and Belen Pérez Solans will attend the 4th International Workshop on Clinical Pharmacology of Anticancer Drugs (ICPAD) to be held November 20th to 21st in Amsterdam, the Netherlands. María Jesus will be chairing one of the sessions of this meeting. Belén will present a poster of her work entitled “Application of the Optimal Design Approach to improve Therapeutic Drug Monitoring of Busulfan in Children receiving Hematopoietic stem cell transplantation (HSCT)”. 

    ..................................

    20/11/19

    The Pharmacometrics and Systems Pharmacology group of the University of Navarra will attend the national “Jornadas de modelización y simulación en biomedicina: Modelbio 2019” to be held November 20th to 22nd in Salamanca, Spain. Different talks will be presented to cover our latest research projects in the Pharmacometrics and Systems Pharmacology area.

    • “Tackling combination treatments selection using QSP M&S: Application to viral hepatits B” presented by Eduardo Asín Prieto.

    • “Pharmacodynamic modelling of pupil diameter after noxious stimulus in patients undergoing surgery” presented by Nicolás Marco Ariño.

    • “A mechanistic Pharmacokinetic-Pharmacodynamic model describing AIP mice treated with a new PBGD protein” presented by Diego Vera Yunca.

    • “Development of a Quantitative Systems Pharmacology model in Crohn’s Disease” presented by Violeta Balbás Martínez.

    ..................................

    27/10/19

    Our group attended the Iberoamerican Pharmacometrics Network Congress 2019 organized by Red Iberoamericana de Farmacometría (RedIF) held October 27th to 30th in La Havana (Cuba). During this meeting, two oral presentations and a seminar session were given to show our latest research projects. 

    ORAL PRESENTATIONS

    • “Model‐based characterization of neutrophil dynamics in children receiving busulfan or treosulfan for haematopoietic stem cell transplant conditioning” presented by Belén Pérez Solans.

    • “A quantitative Systems Pharmacology model characterizing the main immune components involved in Crohn’s Disease to test new therapeutic scenarios” presented by Violeta Balbás Martinez.

    SEMINAR SESSION

    • “Use and Applications of Systems Pharmacology Models” presented by Prof. Iñaki F. Trocóniz.

    Besides, our group gave lectures on concepts, implementation, evaluation and application of population PK/PD analysis using NONMEM.

    ..................................

    23/10/2019

    Professor Iñaki F. Trocóniz presented the work entitled “Computational pharmacokinetic/pharmacodynamic (PKPD) modelling of DNA-based therapies for treatment of rare-diseases” at ACOP10 (American Conference on Pharmacometrics) meeting held October 20th to 23rd in Orlando (Florida).

     

     

     

     

    ..................................

     

    20/10/2019

    Our group members attended the ACOP10 (American Conference on Pharmacometrics) meeting held October 20th to 23rd in Orlando (Florida) and presented different posters covering our latest research projects.

    • “Application of the Optimal Design Approach to improve Therapeutic Drug Monitoring of Busulfan in Children receiving Hematopoietic stem cell transplantation (HSCT).” presented by Belén Pérez Solans.

    • “Systems Pharmacology model characterizing the main immune components involved in Crohn’s Disease to test new therapeutic scenarios.” presented by Violeta Balbás Martinez.

    ..................................

    05/07/19

    Pharmacometrics and Systems PharmacologyOur PhD student Belén Pérez Solans defended her thesis entitled “Application and development of computational approaches to optimize treatment of malignancies using routine clinical data”. This work has been done under the supervision of Prof. Iñaki F. Trocóniz and Dr. Marta Santisteban.

     

     

     

    ..................................

    04/07/19

    Between 1nd and 4th July 2019 The Pharmacometrics and Systems Pharmacology group of the University of Navarra organized the fourth Summer Course on Quantitative Pharmacology.

    There were participants from all over the globe, including Belgium, Brasil, England, France, Germany, Greece, Italy, Malaysia, Portugal, Spain and Sweden. The course covered an Introduction to Pharmacokinetics, Pharmacodynamics and Population Approach, How to build a model, and how to evaluate, validate and share it. PBPK modeling and Systems Pharmacology were also introduced.

    ..................................

    19/06/19

    Iñaki F. Trocóniz will give a computational modeling in translational medicine talk at the “I Simposio de Investigación Traslacional del Centro de Cáncer para investigadores de la Universidad” held in Navarra University, Pamplona. 

    Website

    ..................................

    11/06/19

    Our group attended to the PAGE (Population Approach Group in Europe) meeting 2019 held in Stockholm (Sweden) from 11th June to 14th June and presented different posters covering our latest research projects in Pharmacometrics and Systems Pharmacology area and two oral talks.

    ORAL TALK

    • “Model-based characterization of neutrophil dynamics in children receiving busulfan or treosulfan for hematopoietic stem cell transplant conditioning” will be presented by  Belén Pérez Solans

    • “Disease pharmacokinetic-pharmacodynamic (PKPD) modelling to support the development of gene therapy treatments for rare diseases” will be presented by Zinnia Parra-Guillén

    POSTER SESSION

    • “Quantitative Systems Pharmacology model for the key Interleukins involved in Crohn's Disease” will be presented by Violeta Balbas-Martinez.

    • “Pharmacokinetic-Pharmacodynamic model for Acute Intermittent Porphyria in porphyric mice treated with a new recombinant PBGD protein” will be presented by Diego Vera Yunca.

    • “Pharmacodynamic modelling of pupil diameter after noxious stimulus in patients undergoing surgery” will be presented by Nicolás Marco Ariño.

    ​Website

    ..................................

    05/04/19

    05/04/2019Our PhD student M. Leire Ruiz-Cerdá has defended her thesis entitled “System Pharmacology in Modelling Complex Scenarios: Opportunities and Challenges”. This work has been done under the supervision of Prof. Iñaki F. Trocóniz.

     

     

     

     

    ..................................

    01/03/19

    1 de marzo de 2019Our PhD student Itziar Irurzun Arana defended her thesis entitled “Development and implementation of novel methodologies to improve Pharmacometrics and Systems Pharmacology analysis”. This work has been done under the supervision of Prof. Iñaki F. Trocóniz.

     

     

     

     

    ..................................

     

    07/01/19

    Our PhD student Diego Vera Yunca is joining the Merck Institute for Pharmacometrics (Merck KGaA), located in Lausanne (Switzerland), for a PhD international internship. He will stay there for 8 months under the supervision of Nadia Terranova, PhD. During his internship at Merck, he will work on the modeling of individual tumor lesions and prediction of overall survival.

     
     

  • News 2018

    21/11/18

    ModelBio 2018

    The Pharmacometrics and Systems Pharmacology group of the University of Navarra attended at the national “Jornadas de modelización y simulación en biomedicina: Modelbio 2018” held at Alicante, Spain. There, different talks and posters were presented, covering our latest research projects in Pharmacometrics and Systems Pharmacology area. 

    ORAL TALKS:

    • “Physiologically-Based Pharmacokinetic model for Ciprofloxacin in children with complicated Urinary Tract Infection” presented by Violeta Balbás Martínez.

    • “Mechanistic model of the myeloablative effects of treosulfan and busulfan in paediatric patients undergoing bone marrow transplant” presented by Belén Pérez Solans.

    • “Lipid core nanocapsules enhance unbound quetiapine hippocampal exposure in male and female schizophrenia-phenotyped rats” presented by Fernando Carreño, international student from the Federal University of Rio Grande do Sul, Brasil. 

    • “Mechanistic PK-PD model for acute attacks in porphyric mice” presented by Diego Vera Yunca and winner of the Modelbio student presentation award. 

    POSTER SESSION

    • “Describing the coagulation cascade: from a systems pharmacology model to a semi-mechanistic approach” presented by Leire Ruiz.

    • “Evolutionary cancer modeling for the optimization of dosing schedules” presented by Itziar Irurzun Arana.

    • “PK/PD model for describing the antitumor effect of anti-PD-L1 mAb administered to melanoma bearing mice” presented by Zinnia Parra Guillén.  

    Website

    ..................................

     

    08/11/18

    The Pharmacometrics and Systems Pharmacology group of the University of Navarra attended at the “III International workshop on clinical pharmacology of anticancer drugs.” held at Amsterdam, The Netherlands.

    There, the work entitled “PK/PD model for describing the antitumor effect of anti-PD-L1 mAb administered to melanoma bearing mice.PK/PD model for describing the antitumor effect of anti-PD-L1 mAb administered to melanoma bearing mice”, was presented in a poster format by MJ Garrido.

    Website

     

    ..................................

     

    07/10/18

    The Pharmacometrics and Systems Pharmacology group of the University of Navarra attended at the ACoP conference held at the Loews Coronado Bay Resort near San Diego, CA. There, different posters were presented, covering our latest research projects in Pharmacometrics and Systems Pharmacology area together with one oral talk by Itziar Irurzun Arana who won the Mathematical & Computational Science (MCS) Special Interest Group (SIG) Award.

    ORAL TALK

    • “Optimization of drug delivery in the treatment of prostate cancer using optimal control methods” presented by Itziar Irurzun Arana.

    POSTER SESSION

    • “Mechanistic model of the myeloablative effects of treosulfan and busulfan in paediatric patients undergoing bone marrow transplant” by Belén Pérez Solan would be presented by one of the co-authors.

    • “Optimization of dosing schedules with evolutionary cancer modeling” presented by Itziar Irurzun Arana.

    • “Optimization of drug delivery in the treatment of prostate cancer using optimal control methods” presented by Itziar Irurzun Arana. Poster winner of the MCS SIG Award.

    Website

    ..................................

    01/10/18

    Porto Alegre Systems Pharmacology CourseProf. Iñaki F. Trocóniz gave a two days course of PKPD analysis and Systems Pharmacology, at the “Porto Alegre Systems Pharmacology Course” which was held in Porto Alegre, Brasil.

     

     

     

     

     

    ..................................

    2/07/18

    Between 2nd and 5th July 2018 The Pharmacometrics and Systems Pharmacology group of the University of Navarra organized the third Summer Course on Quantitative Pharmacology.

    There were participants from all over the globe, including Belgium, Brasil, EEUU, England, Germany, Lithuania Portugal, Spain, Sweden, The Netherlands and Uruguay. The course covered an Introduction to Pharmacokinetics, Pharmacodynamics and Population Approach, How to build a model, and how to evaluate, validate and share it. PBPK modeling and Systems Pharmacology were also introduced.

    ..................................

     

    26/05/18

    Our group attended to the PAGE (Population Approach Group in Europe) meeting 2018 held in Montreux (Switzerland) from 26th May to 1st June and present different posters covering our latest research projects in Pharmacometrics and Systems Pharmacology area and one oral talk.

    ORAL TALK

    • “A quantitative modelling framework to inform dose selection of Xentuzumab, a dual insulin-like growth factor-I/II neutralizing antibody in cancer patients” presented by Zinnia Parra-Guillén

    POSTER SESSION

    • “Physiologically-Based Pharmacokinetic model for Ciprofloxacin in healthy Children and extrapolation to children with complicated Urinary Tract Infection” by Violeta Balbas-Martinez.

    • “Disease modelling of repeated acute attacks in an acute intermittent porphyria mouse model” by Diego Vera Yunca

    • “External validation of Systems Pharmacology Models of the Coagulation Network with published data” by Leire Ruiz Cerdá

    • “Mechanistic model of the myeloablative effects of treosulfan and busulfan in pediatric patients undergoing bone marrow transplant” presented by Belén Pérez Solans

    Website

    ..................................

     

    15/05/18

    Marc LavielleProfessor Marc Lavielle gave a course on Advanced population Pharmacokinetic/Pharmacodynamic Analysis using Monolix.

     

     

     

     

     

    ..................................

     

    13/04/18

    “Boolean modeling of Systems Pharmacology Networks with SPIDDORItziar Irurzun Arana, PhD student of the group, won the 1st place poster award with her work “Boolean modeling of Systems Pharmacology Networks with SPIDDOR” in the QSP Day 2018 held in MIT Samberg Conference Center (Cambridge, MA, USA). QSP Day is a conference organized by Applied biomath  focusing on the impact of mathematical modeling in biotechnology and pharmaceutical research. This year's conference included featured speakers from Pfizer, Bristol-Myers Squibb, Zymeworks, and MIT.

    More information

     

     

    ..................................

    16/03/18

    Zinnia Parra Guillén presented the work entitled “The role of systems pharmacology in personalised medicine” at the CESAR annual meeting hold in Berlin.

    Website

    ..................................

    08/01/18

    Itziar Irurzun AranaOur PhD student Itziar Irurzun Arana is joining for six months, as an international exchange PhD student, to the Biostatistics & Computational Biology department in the Dana-Farber Cancer Institute (Harvard medical school) in Boston (USA), under the supervision of Prof. Franziska Michor. The research project would be based on computational modeling in oncology.

    Website

     

     

     

    ..................................

    01/01/18

    Pharmaceutical ResearchProfessor Iñaki F. Trocóniz has become new pharmacometrics section editor of Pharmaceutical Research, an official journal of the American Association of Pharmaceutical Scientist

    Website

     

     

     

  • News 2017

    22/11/17

    Our group organized the “Modelling & Simulation in Biomedicine” conference which was hold in the University of Navarra, Pamplona (Spain). The main goal of the meeting is to bring together all professionals, professors, and students dedicated to modeling and simulation in the area of Biomedicine, allowing the researchers to share their work and spreading their knowledge and experiences about the latest methodologies and tools.

    Zinnia Parra Guillén and Itziar Irurzun Arana, researchers from the P&SP group, were lecturers at the conference with their work:

    · Tutorial on Optimal Experimental Design (Zinnia Parra Guillén)
    · Application of optimal control in a multi-objective therapeutic scenario: Optimizing the treatment of prostate cancer (Itziar Irurzun Arana)

    Website

     

    ..................................

    18/10/17

    Our group members attended to the ACOP8 (American Conference on Pharmacometrics) meeting 2017 held in Fort Lauderdale (Florida) from 15 to 18 October and presented different posters covering our latest research projects:

    • “A quantitative framework for immune liver diseases: understanding HBV infection” presented by Eduardo Asín Prieto and Zinnia Parra Guillén.
    • “Joint modeling of overall survival and circulating biomarker dynamics in melanoma patients treated with IFN-a2b” presented by Itziar Irurzun Arana.

     

     

    ..................................

    13/09/17

    September 13-14, 2017, María J Garrido will give a Lecture in the 2nd international workshop on clinical pharmacology of anticancer drugs, on the topic of ADAs-formation and their implication in the pharmacokineticas and response of monoclonal antibodies.

    The Workshop on Dose Optimization Strategies for Targeted Drugs (Focus on Oncolytics) will take place on in Madrid, Spain. Registration is now open and abstracts can be submitted.

    Website

     

    ..................................

    8/09/17

    Zinnia Parra-Guillén will give an oral presentation “Getting started with Optimal Design for NLME models.” at the Population Optimum Design of Experiments (PODE) 2017 to be held in Basel, Switzerland.
    Website

    ..................................

    1/07/17

    Our PhD student Violeta Balbás Martínez is joining for six months, as an international exchange PhD student, the Bioanalysis department at the Faculty of Pharmaceutical Sciences at Ghent University, Belgium under Prof. dr. An Vermeulen supervision. She will take part of the Belgian based research project on ethical pediatric drug research “Safepedrug” (http://safepedrug.eu/). In particular, the work would be focused on describing in vitro-in vivo correlations of elimination (renal and metabolic) pathways for a set of different drugs commonly used in children, and their integration in large physiologically-based pharmacokinetic (PBPK) models.
    Website

     

     

    ..................................

    27/06/17

    Between 27th and 30th June 2017 The Pharmacometrics and Systems Pharmacology group of the University of Navarra organized a Summer Course on Quantitative Pharmacology.

    There were participants from all over the globe. The course covered an Introduction to Pharmacokinetics, Pharmacodynamics and Population Approach, How to build a model, and how to evaluate, validate and share it. New approaches in Pharmacometrics concepts (PBPK modeling and Systems Pharmacology) were also introduced.

     

    ..................................

    26/06/17

    Our PhD students Itziar Irurzun Arana and Belén Pérez Solans won the BINVAS (Bio Innovation CANVAS) competition organized by Tecnun (Engineering school of the University of Navarra) and BIC Guipúzcoa (Business Innovation Centre) with the project OncoPred, a platform aimed to help oncologists select the best therapy by predicting the response to different standard of care regimens in cancer patients.

    As a prize, the participants have enjoyed a trip to Tel Aviv (Israel) to know the national innovation ecosystem of the country.

     

     

    ..................................

    25/06/17

    Our PhD student Violeta Balbás Martínez attended to the OSP Workshop on Physiologically-Based Pharmacokinetic and Pharmacodynamic (PBPK/PD) Modeling with PK-Sim/MoBi at ISSX 2017, Cologne, Germany.
    Website

    ..................................

    6/06/17

    Our group attended to the PAGE (Population Approach Group in Europe) meeting 2017 held in Budapest (Hungary) from 6 to 9 June and presented different posters covering our latest research projects in Pharmacometrics and Systems Pharmacology area.

    • “Validation of a Network Systems Pharmacology model for Inflammatory Bowel Disease (IBD)” presented by Violeta Balbás Martínez.
    • “One Health: Translational and Reverse Translational Modeling of Inflammatory Bowel Disease using an advanced Boolean Network” by Violeta Balbás Martínez.
    • “Mechanistic multi-scale systems pharmacokinetics model applied for the anticancer drug gemcitabine in pancreatic cancer” by María García-Cremades
    • “Population PD modelling of circulating biomarkers in patients with melanoma treated with interferon alpha2b” presented by Itziar Irurzun Arana.
    • “Exploring the impact of study design on unperturbed tumour growth inhibition modelling” presented by Zinnia Parra-Guillén
    • “Exploring the impact of study design on unperturbed tumour growth inhibition modelling” presented by Leire Ruiz Cerdá

    • “An Immune quantitative network aimed for viral hepatitis B” presented by Eduardo Asín Prieto

    • “Modelling tumour growth and progression free survival of breast cancer patients treated with neoadjuvant therapy” presented by Belén Pérez Solans

    Website

    ..................................

    Our PhD student Itziar Irurzun Arana took part in the inaugural Peer Prize for Bioinformatics. It's a new initiative hosted by Thinkable to better promote and share recent published Bioinformatics research to reach a wider peer audience. To see her submission click on the following link.

  • News 2016

    30/11/16

    The last 30 November Ruben Faelens from SGS Exprimo gave a two days course about "Simulo", a friendly and flexible drug-trial simulator developed as a collaborative work between SGS Exprimo and F. Hoffmann La-Roche Ltd.

    Website

     



     

     

    ..................................

    23/11/16

    Our group attended to the “Modelling & Simulation in Biomedicine” conference organised in Valencia (Spain) with the main goal of bringing their expertise and improve their knowledge in the Systems Pharmacology and Pharmacometrics area. Eduardo Asín Prieto, José David Gómez Mantilla and Itziar Irurzun Arana, researchers from the P&SP group, were lecturers at the conference with their work:

    • “How to initiate a Systems Pharmacology Project: Topological representation of the model” presented by Eduardo Asín Prieto.

    • “SPIDDOR (Systems Pharmacology for effIcient Drug Development On R)” by Itziar Irurzun Arana.

    • “SIMBIOLOGY” presented by José David Gómez Mantilla

    Website

    ..................................

    03/10/16

    Iñaki F. Trocóniz will present a poster entitled “Systems pharmacology model describing the kinetics of insulin-like growth factors” at the American Conference on Pharmacometrics (ACoP7) to be held in Bellevue, Washington from  23rd to 26th October 2016.

    Website

    ..................................

    19/09/16

    Our phd students Violeta Balbás Martínez and Itziar Irurzun Arana present their latest research discoveries and ideas into two posters at the 17th edition of the International Conference on Systems Biology (ICSB16) in Barcelona:

    •“Systems Pharmacology model for Inflammatory Bowel Disease(IBD)” presented by Violeta Balbás Martínez.

    •“SPIDDOR (Systems Pharmacology for effIcient Drug Development On R)” presented by Itziar Irurzun Arana.

    Posters

    DOI: 10.3252/pso.eu.17ICSB.2016

     

    ..................................

     

    12/09/16

    Our phd students María García-Cremades and Belén Peréz Solans assisted to the “Quantitative translational approaches in oncology drug” course held in Lake Como (Italy) from September 12-16, 2016.

    The course was co-organized by Prof. P. Magni and Prof. G. De Nicolao (University of Pavia), Prof. C. Kloft (Freie Universität Berlin), Dr. I. Poggesi (Janssen CILAG, Belgium) and Prof. I. Trocóniz (University of Navarra).

    Website

RESEARH AREAS

  • Pharmacometrics, Mechanistic PK/PD
  • Systems Pharmacology
  • Network-based analysis
  • Nanomedicine
  • Personalized medicine
  • Optimal design
  • Vaccines

THERAPEUTIC AREAS

  • Oncology
  • Autoimmune diseases
  • Infectious diseases
  • Pain