Publicaciones

Estas son las últimas publicaciones en las que ha participado la sección de Farmacología del Departamento de Farmacología y Toxicología de la Universidad de Navarra:

  • Erburu M, Muñoz-Cobo I, Diaz-Perdigon T, Mellini P, Susuki T, Puerta E, Tordera RM.  "SIRT2 inhibition modulate glutamate and serotonin systems in the prefrontal cortex and induces antidepressant-like action" Neuropharmacology, 117: 195-208.

  • Gerenu G, Martisova E, Ferrero H, Carracedo M, Rantamaki T, Ramirez MJ, Gil-Bea FJ. "Modulation of BDNF cleavage by plasminogen-activator inhibitor-1 contributes to Alzheimer's neuropathology and cognitive deficits" Biochem Biophys Acta, 1863(4): 991-1001.

  • Bengoetxea X, Paternain L, Martisova E, Milagro FI, Martinez JA, Campion J, Ramirez MJ. "Effects of perinatal diet and prenatal stress on the beavioural profile of aged male and female rats" J Pharmacol, 31(3): 356-364.

  • Moreno LC, Puerta E, Suarez-Santiago JE, Santos Magalhaes NS, Ramirez MJ, Irache JM. "Effect of the oral administration of nanoencapsulated quercetin on a mouse model of Alzheimer's disease" Int J Pharm, 517(1-1): 50-57.

  • Ferrero H, Solas M, Francis PT, Ramirez MJ. "Serotonin 5-HT6 receptor antagonist in Alzheimer disease: Therapeutic rationales and current development status" CNS Drugs, 31(1): 19-32.

  • 2016

    • Rodríquez-Perdigon M, Tordera RM, Gil-Bea FJ, Gerenu G, Ramírez MJ, Solas M. Down-regulation of glutamatergic terminals (VGLUT1) driven by AB in Alzheimer's disease. Hippocampus, 26(10): 1303-1312.

    • Jais A, Solas M, Backes H, Chaurasia B, Kleinridders A, Theurich S, Mauer J, Steculorum SM, Hampe B, Goldau J, Alber J, Förster CY, Eming SA, Schwaninger M, Ferrara N, Karsenty G, Brüning JC. Myeloid-Cell-Derived VEGF maintains brain glucose uptake and limits cognitive impairment in  obesity. Cell, 165(4): 882-895.

    • Solas M, Milagro FI, Martinez-Urbistondo D, Ramirez MJ, Martinez JA. Precision obesity treatments including pharmacogenetic and nutrigenetic approaches. Trends Pharmacol Sci, 37(7): 575-593.

    • Rodriguez-Perdigon M, Solas M, Moreno-Aliaga MJ, Ramírez MJ. Lipoic acid improves neuronal insulin signalling an drescues cognitive function regulating VGlut1 expression in high-fat-fed rats: Implications for Alzheimer's disease. Biochim Biophys Acta, 1862(4): 511-517.

    •  Yarza R, Vela S, Solas M, Ramirez MJ. c-Jun N-terminal Kinase (JNK) signaling as a therapeutic target for Alzheimer's disease. Front Pharmacol, 12(6): 321.

    • Rodriguez-Perdigón M, Solas M, Ramírez MJ. JNK: A putative link between insulin signaling and VGLUT1 in Alzheimer's disease. J Alzheimers Dis, 50(4): 963-967.

    • Lodeiro M, Puerta E, Ismail MA, Rodríguez-Rodríguez P, Rönnbäck A, Codita A, Parrado-Fernandez C, Maioli S, Gil-Bea F, Merino-Serrais P, Cedazo-Minguez A. Aggregation of the inflammatory S100A8 precedes AB plaque formation in transgenic APP mice: Positive feedback for S100A8 and AB productions. J Gerontol A Biol Sci Med Sci, 50(4): 963-967.

    • Bengoetxea X, de Cerain AL, Azqueta A, Ramirez MJ. Purported interactions of amyloid-B and glucocorticoids in cytotoxicity and genotoxicity: Implications in Alzheimer's disease. J Alzheimers Dis, 54(3): 963-967.

    • Celorrio M, Fernández-Suárwez D, Rojo-Bustamante E, Echeverry-Alzate V, Ramírez MJ, Hillard CJ, López-Moreno JA, Maldonado R, Oyarzabal J, Franco R, Aymerich MS. Fatty acid amide hydrolase inhibition for the symptomatic relief of Parkinson's disease. Brain Behav Immun, 57: 94-105.

    • Ibero-Baraibar I, Perez-Cornago A, Ramirez MJ, Martinez JA, Zulet MA. An increase in plasma homovanillic acid with cocoa extract consumption is associated with the alleviation of depressive symptoms in overweight or obese adults on an energy restricted diet in a randomized controlled trial. J Nutr, 146(4): 897S-904S.

    • Paternain L, Martisova E, Campion J, Martinez JA, Ramirez MJ, Milagro FI. Methyl donor supplementation in rats reverses the deleterious effect of maternal separation on depression-like behaviour. Behav Brain Res, 299: 51-58.

  • 2015

    • Solas M, Puerta E, Ramirez MJ. Treatment options in Alzheimer's disease: The GABA Story. Curr Pharm Des, 21: 4960-4971.

    • Martisova E, Aisa B, Tordera RM, Puerta E, Solas M, Ramírez MJ. Venlafaxine reverses decreased proliferation in the subventricular zone in a rat model of early life stress. Behav Brain Res, 292: 79-82.

    • Bengoetxea X, Rodriguez-Perdigón M, Ramírez MJ. Object recognition test for studying cognitive impairments in animal models of Alzheimer's disease. Front Biosci, 7: 10-29.

    • Ugarte A, Gil-Bea F, García-Barroso C, Cedazo-Minguez A, Ramírez MJ, Franco R, García-Osta A, Oyarzabal J, Cuadrado-Tejedor M. Decreased levels of guanosine 3',5'-monophosphate [cGMP] in cerebrospinal fluid [CSF] are associated with cognitive decline and amyloid pathology in Alzheimer's disease. Neuropathol Appl Neurobiol, 41: 471-482.

    • Maioli S, Lodeiro M, Merino-Serrais P, Falahati F, Khan W, Puerta E, Codita A, Rimondini R, Ramírez MJ, Simmons A, Gil-Bea F, Westman E, Cedazo-Minguez A. Alterations in brain leptin signalling in spite of unchanged CSF leptin levels in Alzheimer's disease. Aging Cell, 14: 122-129.

    • Erburu M, Muñoz-Cobo I, Domínguez-Andrés J, Beltrán E, Suzuki T, Mai A, Valente S, Puerta E, Tordera RM. Chronic stress and antidepressant induced changes in Hdac5 and Sirt2 affect synaptic plasticity. Eur Neuropsychopharmacol, 25(11): 2036-2048.

    • Erburu M, Cajaleon L, Guruceaga E, Venzala E, Muñoz-Cobo I, Beltrán E, Puerta E, Tordera RM. Chronic mild stress and imipramine treatment elicit opposite changes in behavior and in gene expression in the mouse profrontal cortex. Pharm Biochem Behav, 135: 227-236.

    • Beltrán I, Beitia G. Self-directed pharmacotherapy learning to fifth-year pharmacy students in Spain. Indian Journal of Pharmaceutical Education, 49(1): 10-17.

    • Barros-Miñones L, Goñi-Allo B, Suquia V, Beitia G, Aguirre N, Puerta E. Contribution of dopamine to mitochondrial complex I inhibition and dopamienrgic deficits caused by methylenedioxymethamphetamine in mice.  Neuropharmacology, 93: 124-133.

    • Alonso-Perales MM, Lasheras B, Beitia G, Beltrán I, Marcos B, Nuñez-Córdoba JM. Barriers to promote cardiovascular health in community pharmacies: a systematic review. Health Promotion International, 1-14.

    • Orejana L, Barros-Miñones L, Jordan J, Cedazo-Minguez A, Tordera RM, Aguirre N, Puerta E. Sildenafil decreases BACE1 and Cathepsin B levels and reduces APP Amyloidogenic processing in the SAMP8 mouse. J Gerontol A Biol Sci Med Sci, 70: 675-685.

    • Wang X, Puerta E, Cedazo-Minguez A, Hjorth E, Schultzberg M. Insufficient resolution response in the hippocampus of a senescence-accelerated mouse model SAMP8. J Mol Neurosci, 55: 396-405.

  • 2014

    • Harro  J, Kanarik M, Kaart T, Matrov D, Koi K, Mallo T, del Río J, Tordera RM, Ramírez MJ. Revealing the cerebral regions and networks mediatring vulnerability to depression: oxidative metabolism mapping of rat brain. Behav Brain Res, 267: 83- 94

    • Ramirez MJ, Lai KP, Tordera RM, Francis PT. Serotonergic therapies for cognitive symptoms in Alzheimer’s disease: rationale and current status. Drugs, 74: 729-736

    • Cuyas E, Robledo P, Pizarro N, Farré M, Puerta Ruiz de Azúa E, Aguirre N, de la Torre R. 3,4-methylenedioxymethamphetamine induces gene expression changes in rats related to serotonergic and dopaminergic systems but not to neurotoxicity. Neurotox Res, 25: 161-169

    • Steculorum S, Solas M, Brüning JC. The paradox of neural insulin action and resistance in the development of aging-associated diseases. Alzheimers Dement, 10: S3-11.

    • Pujol-Gimenez J, Martisova E, Pérez-Mediavilla A, Lostao MP, Ramírez MJ. Expression of the glucose transporter GLUT12 in Alzheimer ’s disease patients. J Alzheimers Dis, 42: 97-101.

  • 2013

    • Orejana L, Barros-Miñones L, Aguirre N, Puerta E: Implication of JNK pathway on tau pathology and cognitive decline in a senescence-accelerated mouse model. Exp. Gerontol., 48(6): 565-571 .

    • Barros-Miñones L, Martin-de-Saavedra D, Perez-Alvarez S, Orejana L, Suquía V, Goñi-Allo B, Hervias I, López MG, Jordan J, Aguirre N, Puerta E: Inhibition of calpain-regulated p35/cdk5 plays a central role in sildenafil-induced protection against chemical hypoxia produced by malonate. Biochim. Biophys. Acta, 1832(6): 705-717 .

    • Barros-Miñones L, Orejana L, Goñi-Allo B, Suquía V, Hervías I, Aguirre N, Puerta E: Modulation of thje ASK1-MKK3/6-p38/MAPK signalling pathway mediates sildenafil protection against chemical hypoxia caused by malonate. Br. J. Pharmacol., 168(8): 1820-1834.

    • Gerenu G, Dobarro M, Ramírez MJ, Gil-Bea FJ: Early cognitive stimulation compensates for memory and pathological changes in Tg2576 mice. Biochim. Biophys. Acta, 1832: 837-847.

    • Solas M, Gerenu G, Gil-Bea FJ, Ramirez MJ: Mineralocorticoid receptor activation induces insulin resistance through c-Jun N-terminal kinases in response to chronic corticosterone: cognitive implications. J. Neuroendocrinol., 25(4): 350-356.

    • Dobarro M, Orejana L, Aguirre N, Ramirez MJ: Propranolol restores cognitive deficits and improves amyloid and tau pathologies in a senescence-accelerated mouse model. Neuropharmacology, 64(1): 137-44.

    • Solas M, Francis PT, Franco R, Ramirez MJ: CB(2) receptor and amyloid pathology in frontal cortex of Alzheimer's disease patients. Neurobiol. Aging, 34(3): 805-808.

    • Martisova E, Aisa B, Gureñu G, Ramirez MJ: Effects of early maternal separation on biobehavioral and neuropathological markers of Alzheimer's disease in adult male rats. Curr. Alzheimer Res., 10(4): 420-432.

    • Ramirez MJ: 5-HT6 receptors and Alzheimer's disease. Alzheimers Res. Ther., 5(2):15 .

  • 2012

    • Orejana L, Barros-Miñones L, Aguirre N, Puerta E: Implication of JNK pathway on tau pathology and cognitive decline in a senescence-accelerated mouse model. Exp. Gerontol., 48(6): 565-571 .

    • Barros-Miñones L, Martin-de-Saavedra D, Perez-Alvarez S, Orejana L, Suquía V, Goñi-Allo B, Hervias I, López MG, Jordan J, Aguirre N, Puerta E: Inhibition of calpain-regulated p35/cdk5 plays a central role in sildenafil-induced protection against chemical hypoxia produced by malonate. Biochim. Biophys. Acta, 1832(6): 705-717 .

    • Barros-Miñones L, Orejana L, Goñi-Allo B, Suquía V, Hervías I, Aguirre N, Puerta E: Modulation of thje ASK1-MKK3/6-p38/MAPK signalling pathway mediates sildenafil protection against chemical hypoxia caused by malonate. Br. J. Pharmacol., 168(8): 1820-1834.

    • Gerenu G, Dobarro M, Ramírez MJ, Gil-Bea FJ: Early cognitive stimulation compensates for memory and pathological changes in Tg2576 mice. Biochim. Biophys. Acta, 1832: 837-847.

    • Solas M, Gerenu G, Gil-Bea FJ, Ramirez MJ: Mineralocorticoid receptor activation induces insulin resistance through c-Jun N-terminal kinases in response to chronic corticosterone: cognitive implications. J. Neuroendocrinol., 25(4): 350-356.

    • Dobarro M, Orejana L, Aguirre N, Ramirez MJ: Propranolol restores cognitive deficits and improves amyloid and tau pathologies in a senescence-accelerated mouse model. Neuropharmacology, 64(1): 137-44.

    • Solas M, Francis PT, Franco R, Ramirez MJ: CB(2) receptor and amyloid pathology in frontal cortex of Alzheimer's disease patients. Neurobiol. Aging, 34(3): 805-808.

    • Martisova E, Aisa B, Gureñu G, Ramirez MJ: Effects of early maternal separation on biobehavioral and neuropathological markers of Alzheimer's disease in adult male rats. Curr. Alzheimer Res., 10(4): 420-432.

    • Ramirez MJ: 5-HT6 receptors and Alzheimer's disease. Alzheimers Res. Ther., 5(2):15 .

  • 2011

    • Tordera RM, Garcia-Garcia AL, Elizalde N, Segura V, Aso E, Venzala E, Ramirez MJ, Del Rio J: Chronic stress and impaired glutamate function elicit a depressive-like phenotype and common changes in gene expression in the mouse frontal cortex. Eur. Neuropsychopharmacol, 21: 23-32.

    • Jahanshahi A, Le Maitre E, Temel Y, Lanfumey L, Hamon M, Lesch KP, Tordera RM, Del Rio J, Aso E, Maldonado R, Hokfelt T, Steinbusch HW: Altered expression on neuronal tryptophan hydroxylase-2 mRNA in the dorsal and median raphe nuclei of three genetically modified mouse models relevant to depression and anxiety. J. Chem. Neuroanat., 41: 227-233.

    • Hoyle D, Juhasz G, Aso E, Chase D, Del Rio J, Fabre V, Hamon M, Lanfumey L, Lesch KP, Maldonado R, Serra MA, Sharp T, Tordera R, Toro C, Deakin JF: Shared changes in gene expression in frontal cortex of four genetically modified mouse models of depression.  Eur. Neuropsychopharmacol., 21: 3-10.

    • Llorente R, Miguel-Blanco C, Aisa B, Lachize S, Borcel E, Meijer OC, Ramirez MJ, De Kloet ER, Viveros MP: Long term sex-dependent psychoneuroendocrine effects of maternal deprivation and juvenile unpredictable stress in rats. J. Neuroendocrinol., 23: 329-344.

    • Berrade L, Aisa B, Ramirez MJ, Galiano S, Guccione S, Moltzau LR, Levy FO, Nicoletti F,, Battaglia G, Molinaro G, Aldana I, Monge A, Perez-Silanes S; Novel Benzo[b]thiophene deivatives as new potential antidepressants with rapid onset of action. J. Med. Chem., 54; 3086-3090.

    • Gil-Bea FJ, Solas M, Mateo L, Winblad B, Ramirez MJ, Cedazo-Minguez A: Cholinergic hypofunction impairs memory acquisition possibly through hippocampal arc and BDNF downregulation. Hippocampus, 21: 999-1009.

    • Codony X, Vela JM, Ramirez MJ:  5-HT(6) receptor and cognition. Curr. Opin. Pharmacol., 11: 94-100.

    • Cuadrado-Tejedor M, Hervias I, Ricobaraza A, Puerta E, Perez-Roldan JM, Garcia-Barroso C, Franco R, Aguirre N, Garcia-Osta A: Sildenafil restores cognitive function without affecting beta-amyloid burden in a mouse model of Alzheimer's disease. Br. J. Pharmacol., 164: 2029-2041.

    • Orejana L, Barros-Miñones L, Jordan J, Puerta E, Aguirre N: Sildenafil ameliorates cognitive deficits and tau pathology in a senescence-accelerated mouse model. Neurobiol. Aging., 33: 625.e11-20.

    • Puerta E,  Barros-Miñones L, Hervias I, Gomez-Rodriguez V, Orejana L, Pizarro N, de la Torre R, Jordan J, Aguirre N: Long-lasting neuroprotective effect of sildenafil against 3,4-methylenedioxymethamphetamine- induced 5-hydroxytryptamine deficits in the rat brain.  J. Neurosci. Res., 90: 518-528.

    • Cuenca-Lopez MD, Karachitos A, Massarotto L, Oliveira PJ, Aguirre N, Galindo ME, Kmita H, Jordan J: Minocycline exerts uncoupling and inhibiting effects on mitochondrial respiration through adenine nucleotide translocase inhibition. Pharmacol. Res., 65: 120-128.

  • 2010

    • Elizalde N, Pastor PM, Garcia-Garcia AL, Serres F, Venzala E, Huarte J,  Ramirez MJ, Del Rio J, Sharp T, Tordera RM:  Regulation of markers of synaptic function in  mouse  models of  depression:  chronic mild stress and decreased expression of VGLUT1. J. Neurochem., 114: 1302-1314.

    • Francis PT, Ramirez MJ, Lai MK: Neurochemical basis for symptomatic treatment of Alzheimer's disease. Neuropharmacology, 59: 221-229.

    • Puerta E, Pastor F, Dvoracek J, de Saavedra MD, Goñi-Allo B, Jordan J, Hervias I, Aguirre N: Delayed pre-conditioning by 3-nitropropionic acid prevents 3,4-methylenedioxymetamphetamine-induced 5-HT deficits. J. Neurochem., 114: 843-852.

    • Solas M, Aisa B, Mugueta MC, Del Rio J, Tordera RM, Ramirez MJ: Interactions between age, stress and insulin on cognition: implications for Alzheimer's disease. Neuropsychopharmacology, 35: 1664-1673.

    • Puerta E, Pastor F, Dvracek J, de Saavedra MD, Goñi-Allo B, Jordan J, Hervias I, Aguirre N: Delayed pre-conditioning by 3-nitropropionic acid prevents 3,4-methylenedioxymetamphetamine-induced 5-HT deficits. J. Neurochem., 114: 843-852.

    • Garcia-Martinez EM, Sanz-Blasco S, Karachitos A, Bandez MJ, Fernandez-Gomez FJ, Perez-Alvarez S, de Mera RM, Jordan MJ, Aguirre N, Galindo MF, Villalobos C, Navarro A, Kmita H, Jordan J: Mitochondria and calcium flux as targets of neuroprotection caused by minocycline in cerebellar granule cells. Biochem. Pharmacol., 79: 239-250.

    • Elizalde N, Garcia-Garcia AL, Totterdell S, Gendive N, Venzala E, Ramirez MJ, Del Rio J, Tordera RM: Sustained stress-induced changes in mices as a model for chronic depression.  Psychopharmacology, 210: 393-406.

    • Solas M, Aisa B, Mugueta MC, Del Rio J, Tordera RM, Ramírez MJ: Interactions between age, stress and insulin on cognition: implications for Alzheimer's disease.  Neuropsychopharmacology, 35: 1664-1673.

    • Aisa B, Gil-Bea FJ, Solas M, Garcia-Alloza M, Chen CP, Lai MK, Francis PT, Ramirez MJ: Altered NCAM expression associated with the cholinergic system in Alzheimer's disease. J. Alzheimers Dis., 20: 659-668.

    • Puerta E, Hervias I, Goñi-Allo B, Zhang SF, Jordan J, Starkov AA, Aguirre N: Methylenedioxymethamphetamine inhibits mitochondrial complex I activity in mice: a possible mechanism underlying neurotoxicity.  Br. J. Pharmacol., 160: 233-245. 

    • Puerta E, Hervias I, Barros-Miñones L, Jordan J, Ricobaraza A, Cuadrado-Tejedor M, García-Osta A, Aguirre N: Sildenafil protects against 3-nitropropionic acid neurotoxicity through the modulation of calpain, CREB, and BDNF.  Neurobiol. Dis., 38: 237-245.

    • Marcos B, Cabero M, Solas M, Aisa B, Ramírez MJ: Signalling pathways associated with 5-HT6 receptors: relevance for cognitive effects. Int. J. Neuropsychopharmacol., 13: 775-784.

    • Marcos B, Aisa B, Chuang TT, Gil-Bea FJ, Ramirez MJ: Effects pf chronic blockade of 5-HT(6) receptors on NMDA receptor subunits expression. Synapse, 63: 814-816.

    • Gil-Bea FJ, Solas M, Solomon A, Mugueta C, Winblad B, Kivipelto M, Ramirez MJ, Cedazo-Minguez A: Insulin levels are decreased in the cerebrospianl fluid of women with prodomal Alzheimer's disease. J. Alzheimers Dis., 22: 405-413.

    • Perez-Alvarez S, Cuenca-Lopez MD, de Mera RMMF, Puerta E, Karachitos A, Bednarczyk P, Kmita H, Aguirre N, Galindo MF, Jordan J: Methadone induces necrotic-like cell death in SH-SY5Y cells by an impairment of mitochondrial ATP synthesis. Biochim. Biophys. Acta, 1802: 1036-1047.

    • Codony X, Burgueño J, Ramirez MJ, Vela JM: 5-HT6 receptor signal transduction second messenger systems. Int. Rev. Neurobiol., 94: 89-110.

  • 2009

    • García-García AL, Elizalde N, Matrov D, Harro J, Wojcik SM, Venzala E, Ramírez MJ, Rio JD, Tordera RM: Increased vulnerability to depressive-like behavior of mice with decreased expression of VGLUT1. Biol. Psychiatry, 66: 275-282.

    • Puerta E, Hervias I, Goñi-Allo B, Lasheras B, Jordan J, Aguirre N: Phosphodiesterase 5 inhibitors prevent 3,4-methylenedioxy-methamphetamine-induced 5-HT deficits in the rat. J. Neurochem.,  108: 755-766.

    • Aisa B, Elizalde N, Tordera R, Lasheras B, Del Rio J, Ramírez MJ: Effects of neonatal stress on markers of synaptic plasticity in the hippocampus: Implications for spatial memory.  Hippocampus,  19: 1222-1231.

    • Aisa B, Gil-Bea FJ, Marcos B, Tordera R, Lasheras B, del Río J, Ramírez MJ: Neonatal stress vulnerability of cholinergic neurons and cognition in the rat involvement of the HPA axis. Psychoneuroendocrinology, 34: 1495-1505.

    • Marcos B, Aisa B, Chuang TT, Gil-Bea FJ, Ramírez MJ: Effects of chronic blockade of 5-HT(6) receptors on MDMA receptor subunits expression. Synapse, 63(9): 814-816.

    • De la Torre R, Puerta E, Aguirre N: Comment on the letter by Green, Gabrielsson, Marsden, and Fone, MDMA. Psychopharmacology, 204: 379-380.

    • Puerta E, Hervías I, Aguirre N: On the mechanisms underlying 3,4-methylenedioxymethamphetamine toxicity: the dilemma of the chicken and the egg. Neuropsychobiology  60: 119-129.

  • Libros

    • Aguirre N. "Cocaína y MDMA" En Drogodependencias. Eds. B. Lasheras y N. Aguirre, Eurograph, Pamplona, 2001, 93-107.

    • Ramírez MJ. "Hipnóticos y benzodiacepinas" En Drogodependencias. Eds. B. Lasheras y N. Aguirre, Eurograph, Pamplona. 2001, 153-164.

    • Lasheras B. "Opiáceos" En Drogodependencias. Eds. B. Lasheras y N. Aguirre, Eurograph, Pamplona. 2001, 131-151.

    • Solas M, Bengoetxea X, Ferrero H, Muñoz-Cobo I, Vela-Lumbreras S, Ramírez MJ, Puerta E. "Spatial memory assesment: experimental behavioral tasks in rodents" Nova Science Publisher, Nwe York, USA, 2015, 1-30.

Contacto

Contacto:
Edificio de Investigación
C/ Irunlarrea, 1
31008 Pamplona
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