Detalle Publicación

CAR-T cell therapy for multiple myeloma: a practical toolkit for treatment in Brazil

Autores: Hungria, V.; Alfonso Piérola, Ana; Schmidt, J.; Crusoe, E.; Pessoa de Magalhaes Filho, R. J.; Maiolino, A.; Rodríguez Otero, Paula (Autor de correspondencia)
Título de la revista: HEMATOLOGY TRANSFUSION AND CELL THERAPY
ISSN: 2531-1379
Volumen: 45
Número: 2
Páginas: 266 - 274
Fecha de publicación: 2023
Resumen:
Introduction: Chimeric antigen receptor T (CAR-T) cell therapy is an emerging treatment option for relapsed/refractory multiple myeloma (RRMM) that is a multi-step process involving various stakeholders. Appropriate education on the practical logistics is therefore paramount to ensure treatment success. Methods: A group of key opinion leaders met to explore the key elements of setting up and running a CAR-T center in Brazil. For each step in the CAR-T cell therapy process, the experts agreed on basic requirements, gave their key recommendations from practical experience, and considered any remaining unanswered questions. Results: This paper presents best-practice recommendations and advice on how to over -come common challenges for each step in the CAR-T cell therapy process, with a focus on the current situation in Brazil. Key themes throughout the process are collaboration within the multidisciplinary team and with the referring physician, along with communication and education for patients and their caregivers. Conclusion: We believe that the expert insights presented in this paper, in particular on opti-mal patient selection and timing of CAR-T cell therapy, will deepen understanding of the CAR-T process and aid implementation of this novel therapy for patients with RRMM in Brazil.& COPY; 2022 Associacao Brasileira de Hematologia, Hemoterapia e Terapia Celular. Published by Elsevier Espana, S.L.U. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).