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Temporal trends in the use and outcomes of temporary mechanical circulatory support as a bridge to cardiac transplantation in Spain. Final report of the ASIS-TC study

Autores: Barge-Caballero, E. (Autor de correspondencia); González-Vílchez, F.; lmenar-Bonet, L.; Garcia-Cosio Carmena, M. D.; González-Costello, J.; Gómez-Bueno, M.; Castel-Lavilla, M. A.; Lambert-Rodríguez, J. L.; Martínez-Sellés, M.; Mirabet-Pérez, S.; De la Fuente-Galán, L. D.; Hervás-Sotomayor, D.; Rangel-Sousa, D.; Garrido-Bravo, I. P.; Blasco-Peiró, T.; Rabago Juan Aracil, Gregorio; Muñiz, J.; Crespo-Leiro, M. G.
Título de la revista: JOURNAL OF HEART AND LUNG TRANSPLANTATION
ISSN: 1053-2498
Volumen: 42
Número: 4
Páginas: 488 - 502
Fecha de publicación: 2023
Resumen:
BACKGROUND: We aimed to describe recent trends in the use and outcomes of temporary mechanical circulatory support (MCS) as a bridge to heart transplantation (HTx) in Spain.METHODS: Retrospective case-by-case analysis of 1,036 patients listed for emergency HTx while on temporary MCS in 16 Spanish institutions from January 1st, 2010 to December 31st, 2020. Patients were classified in 3 eras according to changes in donor allocation criteria (Era 1: January 2010/May 2014; Era 2: June 2014/May 2017; Era 3: June 2017/December 2020).RESULTS: Over time, the proportion of candidates listed with intra-aortic balloon pumps decreased (Era 1= 55.9%, Era 2 = 32%, Era 3 = 0.9%; p < 0.001), while the proportion of candidates listed with surgi-cal continuous-flow temporary VADs (Era 1= 10.6%, Era 2 = 32%, Era 3 = 49.1%; p < 0.001) and per -cutaneous VADs (Era 1 = 0.3%, Era 2 = 6.3%; Era 3 = 17.2%; p < 0.001) increased. Rates of HTx increased from Era 1 (79.4%) to Era 2 (87.8%), and Era 3 (87%) (p = 0.004), while rates of death before HTx decreased (Era 1 = 17.7%; Era 2 = 11%, Era 3 = 12.4%; p = 0.037) Median time from list-ing to HTx increased in patients supported with intra-aortic balloon pumps (Era 1 = 8 days, Era 2 = 15 days; p < 0.001) but remained stable in other candidates (Era 1 = 6 days; Era 2 = 5 days; Era 3 = 6 days; p = 0.134). One-year post-transplant survival was 71.4% in Era 1, 79.3% in Era 2, and 76.5% in Era 3 (p = 0.112). Preoperative bridging with ECMO was associated with increased 1-year post -trans-plant mortality (adjusted HR=1.71; 95% CI 1.15-2.53; p = 0.008).CONCLUSIONS: During the period 2010 to 2020, successive changes in the Spanish organ allocation protocol were followed by a significant increase of the rate of HTx and a significant reduction of wait-ing list mortality in candidates supported with temporary MCS. One-year post-transplant survival rates remained acceptable. J Heart Lung Transplant 2023;42:488-502 (c) 2022 International Society for Heart and Lung Transplantation. All rights reserved.
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