Detalle Publicación

Somitic positional information guides self-organized patterning of snake scales

Autores: Tzika, A. C. (Autor de correspondencia); Ullate Agote, Asier; Zakany, S.; Kummrow, M.; Milinkovitch, M. C.
Título de la revista: SCIENCE ADVANCES
ISSN: 2375-2548
Volumen: 9
Número: 24
Páginas: eadf8834
Fecha de publicación: 2023
Two influential concepts in tissue patterning are Wolpert's positional information and Turing's self-organized reaction-diffusion (RD). The latter establishes the patterning of hair and feathers. Here, our morphological, genetic, and functional-by CRISPR-Cas9-mediated gene disruption-characterization of wild-type versus scaleless snakes reveals that the near-perfect hexagonal pattern of snake scales is established through interactions between RD in the skin and somitic positional information. First, we show that ventral scale development is guided by hypaxial somites and, second, that ventral scales and epaxial somites guide the sequential RD patterning of the dorsolateral scales. The RD intrinsic length scale evolved to match somite periodicity, ensuring the alignment of ribs and scales, both of which play a critical role in snake locomotion.