Detalle Publicación

Incidence and prognosis of colorectal cancer after heart transplantation: data from the Spanish Post-Heart Transplant Tumor Registry

Autores: Sagastagoitia-Fornie, M. (Autor de correspondencia); Morán-Fernández, L.; Blázquez-Bermejo, Z.; Díaz-Molina, B.; Gómez-Bueno, M.; Almenar-Bonet, L.; López-Granados, A.; González-Vilchez, F.; Mirabet-Pérez, S.; García-Romero, E.; Sobrino-Márquez, J. M.; Rabago Juan Aracil, Gregorio; Castel-Lavilla, M. A.; Blasco-Peiro, T.; Garrido-Bravo, I.; De La Fuente-Galán, L.; Muñiz, J.; Crespo-Leiro, M. G.
ISSN: 0934-0874
Volumen: 36
Páginas: 11042
Fecha de publicación: 2023
In this observational and multicenter study, that included all patients who underwent a heart transplantation (HT) in Spain from 1984 to 2018, we analyzed the incidence, management, and prognosis of colorectal cancer (CRC) after HT. Of 6,244 patients with a HT and a median follow-up of 8.8 years since the procedure, 116 CRC cases (11.5% of noncutaneous solid cancers other than lymphoma registered) were diagnosed, mainly adenocarcinomas, after a mean of 9.3 years post-HT. The incidence of CRC increased with age at HT from 56.6 per 100,000 person-years among under 45 year olds to 436.4 per 100,000 person-years among over 64 year olds. The incidence rates for age-at-diagnosis groups were significantly greater than those estimated for the general Spanish population. Curative surgery, performed for 62 of 74 operable tumors, increased the probability of patient survival since a diagnosis of CRC, from 31.6% to 75.7% at 2 years, and from 15.8% to 48.6% at 5 years, compared to patients with inoperable tumors. Our results suggest that the incidence of CRC among HT patients is greater than in the general population, increasing with age at HT.