Detalle Publicación

3D printed bioresorbable scaffolds for articular cartilage tissue engineering: a comparative study between neat polycaprolactone (PCL) and poly(lactide-b-ethylene glycol) (PLA-PEG) block copolymer

Autores: Urtaza, U. (Autor de correspondencia); Guaresti, O.; Gorronogoitia, I.; Zubiarrain-Laserna, A.; Muiños Lopez, Emma; Granero Molto, Froilan; Lamo de Espinosa Vázquez de Sola, José María; López-Martínez, T.; Mazo Vega, Manuel María; Prosper Cardoso, Felipe; Zaldua, A. M.; Anakabe, J.
Título de la revista: BIOMEDICAL MATERIALS
ISSN: 1748-6041
Volumen: 17
Número: 4
Páginas: 045028
Fecha de publicación: 2022
This work identifies and describes different material-scaffold geometry combinations for cartilage tissue engineering (CTE). Previously reported potentially interesting scaffold geometries were tuned and printed using bioresorbable polycaprolactone and poly(lactide-b-ethylene) block copolymer. Medical grades of both polymers were 3D printed with fused filament fabrication technology within an ISO 7 classified cleanroom. Resulting scaffolds were then optically, mechanically and biologically tested. Results indicated that a few material-scaffold geometry combinations present potential for excellent cell viability as well as for an enhance of the chondrogenic properties of the cells, hence suggesting their suitability for CTE applications.