Detalle Publicación

Metabolic fate and cardiometabolic effects of phenolic compounds from red-fleshed apple in hypercholesterolemic rats: A comparative study with common white-fleshed apple. The AppleCOR Study

Autores: Yuste, S. ; Ludwig Sanz Orrio, Iziar Amaia; Romero, M.P.; Piñol-Felis, C. ; Catalán, U.; Pedret, A. ; Valls, R.M. ; Fernández-Castillejo, S. ; Motilva, M. J. ; Maciá, A. ; Rubió, L. (Autor de correspondencia)
ISSN: 1613-4125
Volumen: 65
Número: 10
Páginas: e2001225
Fecha de publicación: 2021
The present study aims to investigate the metabolic fate and the cardiometabolic effects of phenolic compounds provided by a red-fleshed apple variety biofortified in anthocyanins (ACN). Wistar rats are fed with high-fat diet (HFD) to induce hypercholesterolemia and supplemented with red-fleshed apple (HFD+R), white-fleshed apple (HFD+W), or an ACN-rich infusion from aronia fruit (HFD+A) providing matched content and profile of ACN. Plasma biochemical parameters, histological analysis, and phenol biological metabolites are determined. Plasma, urine, and feces show a significant increase of ACN metabolites after HFD+R and HFD+A, while flavan-3-ols are significantly increased after HFD+W and dihydrochalcones derivatives increased after both apples supplementation. A cardioprotective effect is observed after both apples and aronia infusion supplementation in the reduction of aortic thickness. The kidney function is improved after all supplementations and a decrease in insulin plasma concentration after both apples supplementation (HFD+R and HFD+W) is also observed. The findings support that ACN without apple matrix can induce cardioprotective effects. ACN or flavan-3-ols, together with dihydrochalcones, compose a phenolic phytocomplex in red- and white-fleshed apples, respectively, which can act synergistically in the attenuation of cardiovascular outcomes in hypercholesterolemic rats.