Detalle Publicación

Neurogenetic traits outline vulnerability to cortical disruption in Parkinson's disease

Autores: Basaia, S.; Agosta, F.; Diez, I.; Bueicheku, E.; D'Oleire Uquillas, F.; Delgado-Alvarado, M.; Caballero-Gaudes, C.; Rodríguez Oroz, María Cruz; Stojkovic, T.; Kostic, V. S.; Filippi, M.; Sepulcre, J. (Autor de correspondencia)
Título de la revista: NEUROIMAGE. CLINICAL
ISSN: 2213-1582
Volumen: 33
Páginas: 102941
Fecha de publicación: 2022
The genetic traits that underlie vulnerability to neuronal damage across specific brain circuits in Parkinson's disease (PD) remain to be elucidated. In this study, we characterized the brain topological intersection between propagating connectivity networks in controls and PD participants and gene expression patterns across the human cortex - such as the SNCA gene. We observed that brain connectivity originated from PD-related pathology epicenters in the brainstem recapitulated the anatomical distribution of alpha-synuclein histopathology in postmortem data. We also discovered that the gene set most related to cortical propagation patterns of PDrelated pathology was primarily involved in microtubule cellular components. Thus, this study sheds light on new avenues for enhancing detection of PD neuronal vulnerability via an evaluation of in vivo connectivity trajectories across the human brain and successful integration of neuroimaging-genetic strategies.