Detalle Publicación

Identification of sex-specific biomarkers predicting new-onset heart failure

Autores: Raafs, A.; Verdonschot, J.; Ferreira, J. P.; Wang, P.; Collier, T.; Henkens, M.; Bjorkman, J.; Boccanelli, A.; Clark, A. L.; Delles, C.; Díez Martínez, Domingo Francisco Javier; González Miqueo, Aránzazu; Girerd, N.; Jukema, J. W.; Pinet, F.; Rossignol, P.; Thum, T.; Vodovar, N.; de Boer, R. A.; van Empel, V.; Staessen, J. A.; Hazebroek, M.; Cleland, J.; Zannad, F.; Heymans, S. (Autor de correspondencia)
Título de la revista: ESC HEAR FAILURE
ISSN: 2055-5822
Volumen: 8
Número: 5
Páginas: 3512 - 3520
Fecha de publicación: 2021
Aims Heart failure (HF) is common in both men and women, yet disease pathophysiology, presentation, and progression differ between sexes. Studies addressing whether biomarkers predict new onset HF sex-specifically are scarce. This study therefore aims to test the sex-specificity of 252 protein biomarkers for new-onset HF. Methods and results A matched case-control design in patients selected from cohorts within the HOMAGE consortium was used. Cases (new-onset HF, n = 562) and controls (n = 780) were matched for cohort (PREDICTOR, HEALTH-ABC, & PROSPER), follow-up time (defined as time from entry to incident HF), and age. Incident HF was defined as first hospitalization for HF. Targeted plasma proteins (n = 252) were measured using Proximity Extension Assay technology from O-link. To look for sex differences for new onset HF, we adjusted for cohort, age, and baseline clinical parameters. At baseline, women had a biomarker profile reflecting activated metabolism and immune responses. However, none of the biomarkers had a significant interaction with sex in predicting new onset HF, but four biomarkers had a trend towards sex-specificity (P < 0.013). E-selectin and interleukin 1 receptor antagonist were more female-specific, whereas IL17A and CHIT1 tended to be male sex-specific for incident HF. Conclusions The majority of biomarkers associated with incident HF did not significantly differ between women and men, despite clear differences in biomarkers at baseline.