Detalle Publicación

Safety of anti-CGRP monoclonal antibodies in patients with migraine during the COVID-19 pandemic: present and future implications
Autores: Caronna, E.; Gallardo, V. J.; Alpuente, A.; Torres-Ferrus, M.; Sánchez-Mateo, N. M.; Viguera-Romero, J.; López-Veloso, A. C.; López-Bravo, A.; Gago-Veiga, A. B.; Irimia Sieira, Pablo; Porta-Etessam, J.; Santos-Lasaosa, S.; Pozo-Rosich, P. (Autor de correspondencia); Spanish CGRP-COVID Study Grp
Título de la revista: NEUROLOGIA
ISSN: 0213-4853
Volumen: 36
Número: 8
Páginas: 611 - 617
Fecha de publicación: 2021
Lugar: WOS
Background and objective: CGRP, a neuropeptide involved in migraine pathophysiology, is also known to play a role in the respiratory system and in immunological conditions such as sepsis. We analyzed the impact of the use of CGRP antagonists in patients with migraine during the COVID-19 pandemic, caused by the SARS-CoV-2 coronavirus. Methods: This is a multicentre cross-sectional study. From May to November 2020, through a national survey distributed by the Spanish Society of Neurology, we collected data about the presence of COVID-19 symptoms including headache and their characteristics and severity in patients with migraine treated with anti-CGRP monoclonal antibodies (mAb), and compared them with patients with migraine not receiving this treatment. We also conducted a subanalysis of patients with COVID-19 symptoms. Results: We recruited 300 patients with migraine: 51.7% (155/300) were taking anti-CGRP mAbs; 87.3% were women (262/300). Mean age (standard deviation) was 47.1 years (11.6). Forty-one patients (13.7%) met diagnostic criteria for COVID-19, with no statistically significant difference between patients with and without anti-CGRP mAb treatment (16.1% vs 11.0%, respectively; P = .320). Of the patients with COVID-19, 48.8% (20/41) visited the emergency department and 12.2% (5/41) were hospitalised. Likewise, no clinical differences were found between the groups of patients with and without anti-CGRP mAb treatment. Conclusion: Anti-CGRP mAbs may be safe in clinical practice, presenting no association with increased risk of COVID-19.