Detalle Publicación

Clinical and Sonographic Classification of Neurofibromas in Children with Neurofibromatosis Type 1-A Cluster Analysis

Autores: García Martinez, Francisco Javier (Autor de correspondencia); Alfageme, F.; Duat-Rodríguez, A.; Andrés-Esteban, E. M.; Hernández-Martín, A.
Título de la revista: ULTRASCHALL IN DER MEDIZIN
ISSN: 0172-4614
Volumen: 44
Número: 2
Páginas: e118 - e125
Fecha de publicación: 2021
Resumen:
Purpose: High-frequency ultrasound allows the accurate identification of neurofibromas in neurofibromatosis type 1 (NF1). This study aimed to analyze the ultrasound features of neurofibromas in children with NF1, to establish a classification based on the clinical and sonographic patterns of the different types of neurofibromas, and to evaluate the interobserver correlation coefficient (¿) of this classification. Materials and methods: In this prospective, single referral center observational study, clinical and ultrasound findings of neurofibromas in children diagnosed with NF 1 were analyzed. To identify the ultrasound patterns, a cluster analysis allowing the inclusion of both clinical and ultrasound data was designed. The ¿ coefficient was calculated using 9 external evaluators. Results: 265 ultrasound scans were performed on a total of 242 neurofibromas from 108 children diagnosed with NF1. Cluster analysis allowed the identification of 9 patterns (Snedecor's F, P < 0.001) classified as "classic" cutaneous neurofibroma, blue-red neurofibroma, pseudoatrophic neurofibroma, nodular subcutaneous neurofibroma, diffuse subcutaneous neurofibroma, congenital cutaneous neurofibroma, congenital plexiform neurofibroma, congenital diffuse and plexiform neurofibroma, and subfascial neurofibroma. The ¿ coefficient of the interobserver ratings was 0.82. Conclusion: Patterns identified in the cluster analysis allow neurofibromas to be classified with a very high interobserver correlation.
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