Detalle Publicación

Galectin-3 inhibition with modified citrus pectin in hypertension

Autores: Lau, E. S.; Liu, E.; Paniagua, S. M.; Sarma, A. A.; Zampierollo, G.; López Salazar, Begoña; Diez, J.; Wang, T. J.; Ho, J. E. (Autor de correspondencia)
Título de la revista: JACC. BASIC TO TRANSLATIONAL SCIENCE
ISSN: 2452-302X
Volumen: 6
Número: 1
Páginas: 12 - 21
Fecha de publicación: 2021
Resumen:
We investigated the effect of galectin-3 (Gal-3) inhibition with modified citrus pectin on markers of collagen metabolism in a proof-of-concept randomized placebo-controlled trial of participants with elevated Gal-3 levels and hypertension. Although higher Gal-3 levels were associated with female sex, diabetes, and reduced glomerular filtration rate in cross-sectional analyses, treatment with modified citrus pectin did not change collagen markers. The effect of Gal-3 inhibition among individuals with heart failure warrants further investigation. (C) 2021 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.
Impacto: