Detalle Publicación

Destress and do not suppress: targeting adrenergic signaling in tumor immunosuppression

Título de la revista: JOURNAL OF CLINICAL INVESTIGATION
ISSN: 0021-9738
Volumen: 129
Número: 12
Páginas: 5086 - 5088
Fecha de publicación: 2019
Resumen:
Tumor-induced immunosuppression is a common obstacle for cancer treatment. Adrenergic signaling triggered by chronic stress participates in the creation of an immunosuppressive microenvironment by promoting myeloid-derived suppressor cell (MDSC) proliferation and activation. In this issue of the JCI, Mohammadpour et al. elegantly delve into the mechanisms underlying MDSC contribution to tumor development. They used in vitro and in vivo mouse models to demonstrate that chronic stress results in MDSC accumulation, survival, and immune-inhibitory activity. Of therapeutic relevance, the authors showed that propranolol, a commonly prescribed beta-blocker, can reduce MDSC immunosuppression and enhance the effect of other cancer therapies.
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