ARTÍCULO

Trabecular bone score in active or former smokers with and without COPD

Autores: González Gutiérrez, Jéssica; Rodríguez Fraile, María Macarena; Rivera Ortega, Pilar; Restituto Aranguíbel, Patricia; Colina Lorda, María Inmaculada; Calleja Canelas, María de los Desamparados; Alcaide Ocaña, Ana Belén; Campo Ezquibela, Aránzazu; Berto Botella, Juan Antonio; Seijo Maceiras, Luis Miguel; Pérez Warnisher, María Teresa; Zulueta Francés, Javier Joseph; Varo Cenarruzabeitia, Miren Nerea; De Torres Tajes, Juan Pablo
Título de la revista: PLOS ONE
ISSN: 1932-6203
Volumen: 14
Número: 2
Páginas: e0209777
Fecha de publicación: 2019
Resumen:
BACKGROUND: Smoking is a recognized risk factor for osteoporosis. Trabecular bone score (TBS) is a novel texture parameter to evaluate bone microarchitecture. TBS and their main determinants are unknown in active and former smokers. OBJECTIVE: To assess TBS in a population of active or former smokers with and without Chronic Obstructive Pulmonary Disease (COPD) and to determine its predictive factors. METHODS: Active and former smokers from a pulmonary clinic were invited to participate. Clinical features were recorded and bone turnover markers (BTMs) measured. Lung function, low dose chest Computed Tomography scans (LDCT), dual energy absorptiometry (DXA) scans were performed and TBS measured. Logistic regression analysis explored the relationship between measured parameters and TBS. RESULTS: One hundred and forty five patients were included in the analysis, 97 (67.8%) with COPD. TBS was lower in COPD patients (median 1.323; IQR: 0.13 vs 1.48; IQR: 0.16, p = 0.003). Regression analysis showed that a higher body mass index (BMI), younger age, less number of exacerbations and a higher forced expiratory volume-one second (FEV1%) was associated with better TBS (ß = 0.005, 95% CI:0.000-0.011, p = 0.032; ß = -0.003, 95% CI:-0.007(-)-0.000, p = 0.008; ß = -0.019, 95% CI:-0.034(-)-0.004, p = 0.015; ß = 0.001, 95% CI:0.000-0.002, p = 0.012 respectively). The same factors with similar results were found in COPD patients. CONCLUSIONS: A significant proportion of active and former smokers with and without COPD have an affected TBS. BMI, age, number of exacerbations and the degree of airway obstruction predicts TBS values in smokers with and without COPD. This important information should be considered when evaluating smokers at risk of osteoporosis.