Detalle Publicación

Established and emerging uses of 5-ALA in the brain: an overview

Autores: Diez Valle, Ricardo (Autor de correspondencia); Hadjipanayis, C. G.; Stummer, W.
Título de la revista: JOURNAL OF NEURO-ONCOLOGY
ISSN: 0167-594X
Volumen: 141
Número: 3
Páginas: 487 - 494
Fecha de publicación: 2019
Introduction5-aminolevulinic acid (5-ALA) was approved by the FDA in June 2017 as an intra-operative optical imaging agent for patients with gliomas (suspected World Health Organization Grades III or IV on preoperative imaging) as an adjunct for the visualization of malignant tissue during surgery. 5-ALA fluorescence-guided surgery (FGS) has been in widespread use in Europe and other continents since 2007.MethodsWe reviewed the data available and summarize the most important known uses of 5-ALA FGS and its potential future applications.Results/conclusionsThe technique has been extensively studied, and more than 300 papers have been published on this topic. Visualization of high-grade glioma tissue is robust and reproducible, and can impact the extent of tumor resection and patient outcomes. 5-ALA FGS for other kind of tumors needs further development