ARTÍCULO

Tissue mimicry in morphology and composition promotes hierarchical matrix remodeling of invading stem cells in osteochondral and meniscus scaffolds

Autores: Stuckensen, K.; Schwab, A.; Knauer, M.; Muiños Lopez, Emma; Ehlicke, F. ; Reboredo, J.; Granero Molto, Froilan; Gbureck, U. ; Prosper Cardoso, Felipe; Walles, H.; Groll, J. (Autor de correspondencia)
Título de la revista: ADVANCED MATERIALS
ISSN: 0935-9648
Volumen: 30
Número: 28
Páginas: e1706754
Fecha de publicación: 2018
Lugar: WOS
Resumen:
An integral approach toward in situ tissue engineering through scaffolds that mimic tissue with regard to both tissue architecture and biochemical composition is presented. Monolithic osteochondral and meniscus scaffolds are prepared with tissue analog layered biochemical composition and perpendicularly oriented continuous micropores by a newly developed cryostructuring technology. These scaffolds enable rapid cell ingrowth and induce zonal-specific matrix synthesis of human multipotent mesenchymal stromal cells solely through their design without the need for supplementation of soluble factors such as growth factors.