ARTÍCULO

Optimal dynamic control approach in a multi-objective therapeutic scenario: application to drug delivery in the treatment of prostate cancer

Autores: Irurzun Arana, Itziar; Janda Galán, Álvaro; Ardanza-Trevijano Moras, Sergio; Fernández de Trocóniz Fernández, José Ignacio
Título de la revista: PLOS COMPUTATIONAL BIOLOGY
ISSN: 1553-7358
Volumen: 14
Número: 4
Páginas: e1006087
Fecha de publicación: 2018
Resumen:
Numerous problems encountered in computational biology can be formulated as optimization problems. In this context, optimization of drug release characteristics or dosing schedules for anticancer agents has become a prominent area not only for the development of new drugs, but also for established drugs. However, in complex systems, optimization of drug exposure is not a trivial task and cannot be efficiently addressed through trial-error simulation exercises. Finding a solution to those problems is a challenging task which requires more advanced strategies like optimal control theory. In this work, we perform an optimal control analysis on a previously developed computational model for the testosterone effects of triptorelin in prostate cancer patients with the goal of finding optimal drug-release characteristics. We demonstrate how numerical control optimization of non-linear models can be used to find better therapeutic approaches in order to improve the final outcome of the patients.