Curriculum de nuestros investigadores - Investigacion

Detalle Profesor

Nuestros investigadores

Marcos Llorente Ortega

mllorenteo@unav.es

Centro(s)

Unidad de Educación Médica

Facultad de Medicina Universidad de Navarra

Líneas de investigación

Biomedical Engineering, 3D printing, Medical devices

Grupos de investigación

Obesidad, nutrición y metabolismo de la CUN

Publicaciones
- Revistas (6)
- Capítulos de libros (1)
Proyectos investigación
- Nacionales y regionales(1)
Docencia

Revistas

Autores: Unamuno Iñurritegui, Xabier; Gómez-Ambrosi, J; Becerril, Sara; et al.

Título: Changes in mechanical properties of adipose tissue after bariatric surgery driven by extracellular matrix remodelling and neovascularization are associated with metabolic improvements

Revista: ACTA BIOMATERIALIA ISSN: 1742-7061

Año: 2022 Vol.: 141 Págs.: 264 - 279

Resumen

Biomechanical properties of adipose tissue (AT) are closely involved in the development of obesity associated comorbidities. Bariatric surgery (BS) constitutes the most effective option for a sustained weight loss in addition to improving obesity-associated metabolic diseases including type 2 diabetes (T2D). We aimed to determine the impact of weight loss achieved by BS and caloric restriction (CR) on the biomechanical properties of AT. BS but not CR changed the biomechanical properties of epididymal white AT (EWAT) from a diet-induced obesity rat model, which were associated with metabolic improvements. We found decreased gene expression levels of collagens and Lox together with increased elastin and Mmps mRNA levels in EWAT after BS, which were also associated with the biomechanical properties. Moreover, an increased blood vessel density was observed in EWAT after surgery, confirmed by an up regulation of Acta2 and Antxr1 gene expression levels, which was also correlated with the biomechanical properties. Visceral AT from patients with obesity showed increased stiffness after tensile tests compared to the EWAT from the animal model. This study uncovers new insights into EWAT adaptation after BS with decreased collagen crosslink and synthesis as well as an increased degradation together with enhanced blood vessel density providing, simultaneously, higher stiffness and more ductility. Statement of Significance Biomechanical properties of the adipose tissue (AT) are closely involved in the development of obesity associated comorbidities. In this study, we show for the first time that biomechanical properties of AT determined by E , UTS and strain at UTS are decreased in obesity, being increased after bariatric surgery by the promotion of ECM remodelling and neovascularization. Moreover, these changes in biomechanical properties are associated with improvements in metabolic homeostasis. Consistently, a better characterization of the plasticity and biomechanical properties of the AT after bariatric surgery opens up a new field for the development of innovative strategies for the reduction of fibrosis and inflammation in AT as well as to better understand obesity and its associated comorbidities.

Autores: Llorente-Ortega, M; Fernández, Secundino (Autor de correspondencia)

Título: Design and development of an automated feedback and scoring system for self-directed learning of flexible nasal endoscopy with an airway simulator

Revista: SIMULATION IN HEALTHCARE ISSN: 1559-2332

Año: 2021 Vol.: 16 N°: 5 Págs.: 367 - 371

Resumen

Introduction: The AirSim Multi (TruCorp) airway simulator is used to practice exploration of the upper respiratory tract with a flexible endoscope to assess the nasal cavities, their structures and spaces (inferior, middle, and superior turbinates and meati), and the nasopharynx. The passage of the flexible endoscope through the nose is usually the most annoying and painful maneuver to continue the exploration of the airway to the pharynx and larynx. For this reason, it is important to develop self-assessment training systems in safe environments that allow trainees to develop the necessary skills to carry out this type of assessment with the least inconvenience and the greatest security. Despite this simulator's accurate anatomical reproduction of the tract, its suitability as a tool for endoscope exploration learning is limited without a feedback system. Effective endoscopic exploration should not cause pain or lesions, not only for comfort and safety reasons, but also because only when discomfort is minimized is a complete and detailed exploration of the anatomical structures possible. The objective of the project was to provide a feedback system from the simulator to the trainee that would facilitate improvements in self-trained skills needed to perform an endoscopic exploration of the airways. Methods: A device based on the Hall-effect sensor was designed and placed outside the airway in the upper nasal turbinate. This device detects changes in the magnetic flux, indicating a displacement on the nasal turbinate due to endoscopic maneuvers that deform the inside of the simulator and would be expected to be harmful or painful in real life. Results: The improved AirSim provides audible and visual feedback during exploration to indicate a change on the nasal turbinate due to endoscopic contact with the turbinate surface that would be expected to be harmful or painful in real life. We expect this feature to facilitate self-learning with minimal professional supervision and reduce the overall training time required to successfully perform a complete exploration of the airway. Conclusions: The inclusion of sensors on a passive simulator is a cost-effective measure that may allow for better training experiences using AirSim Multi simulator from the TruCorp company. Our improved simulator turns endoscopic exploration into a self-assessed exercise suitable for all disciplines and level of learners.

Autores: Díez N (Autor de correspondencia); Pacheco, S.; Llorente-Ortega, M; et al.

Título: Validation of a sensor-fitted simulator for upper airway examination

Revista: OTOLARYNGOLOGY-HEAD AND NECK SURGERY ISSN: 0194-5998

Año: 2021 Vol.: 164 N°: 2 Págs.: 339 - 345

Resumen

Autores: Guarnieri, A (Autor de correspondencia); Carnero, Elena María; Bleau, Anne Marie; et al.

Título: Ocular surface analysis and automatic non-invasive assessment of tear film breakup location, extension and progression in patients with glaucoma

Revista: BMC OPHTHALMOLOGY ISSN: 1471-2415

Año: 2020 Vol.: 20 N°: 1 Págs.: 12

Resumen

Autores: Becerril, Sara; Rodríguez, Amaia; Catalán, V; et al.

Título: Targeted disruption of the iNOS gene improves adipose tissue inflammation and fibrosis in leptin-deficient ob/ob mice: role of tenascin C

Revista: INTERNATIONAL JOURNAL OF OBESITY ISSN: 0307-0565

Año: 2018 Vol.: 42 N°: 8 Págs.: 1458 - 1470

Resumen

Autores: Jiménez Ormabera, B.; Diez Valle, Ricardo; Zaratiegui Fernández, J.; et al.

Título: Impresión 3D en neurocirugía modelo específico para pacientes con craneosinostosis

Revista: NEUROCIRUGIA ISSN: 1130-1473

Año: 2017 Vol.: 28 N°: 6 Págs.: 260 - 265

Resumen

Capítulos de libros

Autores: Morer, María de la Paz; Paredes, J; Llorente-Ortega, M; et al.

Título: Design of a neurosurgery training simulator with additive manufacturing to practice the suture of the dura mater

Libro: Advances in Design Engineering II. INGEGRAF 2021

Lugar de Edición: Cham Editorial: Springer International Publishing Año: 2021 Págs.: 182 - 190

ISBN: 978-3-030-92426-3

Resumen

Curso 2021 - 2022

- Ingeniería Clínica y Normativa Regulatoria (Ing. Gr.). Universidad de Navarra - Escuela de Ingeniería .

- Proyecto Fin de Grado (DI) (Ing.Gr.). Universidad de Navarra - Escuela de Ingeniería .

- Prácticas en Empresa (Ing.Gr.). Universidad de Navarra - Escuela de Ingeniería .

- Proyecto Fin de Grado (DI) (Ing.Gr.). Universidad de Navarra - Escuela de Ingeniería .

- Técnicas en simulación-B . Universidad de Navarra - Facultad de Medicina .

- Proyecto Fin de Grado (BIO) (Ing.Gr.). Universidad de Navarra - Escuela de Ingeniería .

- Prácticas en Empresa (Ing.Gr.). Universidad de Navarra - Escuela de Ingeniería .

Curso 2020 - 2021

- Ingeniería Clínica y Normativa Regulatoria (Ing. Gr.). Universidad de Navarra - Escuela de Ingeniería .

- Prácticas en Empresa (Ing.Gr.). Universidad de Navarra - Escuela de Ingeniería .

- Proyecto Fin de Grado (DI) (Ing.Gr.). Universidad de Navarra - Escuela de Ingeniería .

- Prácticas en Empresa (Ing.Gr.). Universidad de Navarra - Escuela de Ingeniería .

- Proyecto Fin de Grado (BIO) (Ing.Gr.). Universidad de Navarra - Escuela de Ingeniería .

- Técnicas en simulación-B . Universidad de Navarra - Facultad de Medicina .

- Proyecto Fin de Grado (BIO) (Ing.Gr.). Universidad de Navarra - Escuela de Ingeniería .

- Técnicas en simulación básica (F.Medicina). Universidad de Navarra - Facultad de Medicina .

Curso 2019 - 2020

- Ingeniería Clínica y Normativa Regulatoria (Ing. Gr.). Universidad de Navarra - Escuela de Ingeniería .

- Prácticas en Empresa (Ing.Gr.). Universidad de Navarra - Escuela de Ingeniería .

- Proyecto Fin de Grado (BIO) (Ing.Gr.). Universidad de Navarra - Escuela de Ingeniería .

- Prácticas en Empresa (Ing.Gr.). Universidad de Navarra - Escuela de Ingeniería .

- Proyecto Fin de Grado (BIO) (Ing.Gr.). Universidad de Navarra - Escuela de Ingeniería .

Curso 2018 - 2019

- Valoración de la evidencia científica (F.Medicina). Universidad de Navarra - Facultad de Medicina .

- Clínica Práctica VIII (F. Medicina). Universidad de Navarra - Facultad de Medicina .

- Iniciación a la clínica (F.Medicina). Universidad de Navarra - Facultad de Medicina .

- Medicina Molecular y Regenerativa (F.Medicina). Universidad de Navarra - Facultad de Medicina .

- Técnicas en simulación básica (F.Medicina). Universidad de Navarra - Facultad de Medicina .

Universidad de Navarra

Menú de navegación

Menú de navegación

Menú de navegación

Curriculum de nuestros investigadores - Investigacion

Detalle Profesor

Marcos Llorente Ortega

Menú de navegación

Selector de idioma

Menú de navegación

Menú de navegación

Ruta de navegación

Curriculum de nuestros investigadores - Investigacion

Detalle Profesor

Marcos Llorente Ortega

Publicaciones

Revistas (6)

Capítulos de libros (1)

Proyectos investigación

Nacionales y regionales(1)

Docencia

Curso 2021 - 2022

Curso 2020 - 2021

Curso 2019 - 2020

Curso 2018 - 2019