Nuestros investigadores

Cristina Auba Guedea

Publicaciones científicas más recientes (desde 2010)

Autores: Farago-Magrini, S. ; Auba Guedea, Cristina; Camargo, C.; et al.
ISSN 0364-216X  Vol. 42  Nº 3  2018  págs. 702 - 707
Background Breast reconstruction after mastectomy is a part of breast cancer treatment. There is a lack of data regarding the impact of reconstruction over psychological traits and quality of life. The aim of this study is to evaluate personality changes in patients who underwent recon-tructive surgery. Methods Thirty-seven women underwent breast reconstruction. These women took the Crown-Crisp Experiential Index before and after the different procedures. The questionnaire analyzes: (a) the satisfaction level with personal relationships before and after surgery, and the level of satisfaction with surgical results and (b) personality index. Comparisons of preoperative and postoperative personality traits were made by using the Crown-Crisp test and analyzed by Chi-square test. Correlations between preoperative concerns and CCEI traits and correlations between physical aspects and Crown-Crisp, both preoperatively and postoperatively, were performed using the Spearman test. Results We found statistically significant differences in the following traits: anxiety anticipating possible technique failures (p = 0.01); cancer recurrence (p = 0.04); dissatisfaction with results (p = 0.02); phobic anxiety for possible technique failure (p = 0.03); obsessionality with possible technique failure (p = 0.01); preoccupations around cancer recurrence (p = 0.01) and dissatisfaction with results (p = 0.03); somatic of technique failure (p = 0.05); and finally, depression and hysteria traits in response to surgical procedures except anesthesia. Conclusion This prospective study suggests that personality traits define perceptions of body image, which has an influence over quality of life and satisfaction with results.
Autores: Yanguas Andrés, Alba; Garasa, S.; Teijeira Sánchez, Álvaro; et al.
ISSN 1664-3224  Vol. 9  2018  págs. 2084
The quantity of T-lymphocytes reaching the draining lymph nodes from tumors is likely important to mount effective distant responses and for the establishment of long term systemic memory. Looking into mechanisms behind lymphocyte egress, we directed our attention to leukocyte adhesion mechanisms inside tumors. Here we demonstrate that activated T-cells form intra-tumor aggregates in a LFA-1-ICAM-1-dependent fashion in mouse models of melanoma and breast cancer. We also provide evidence of the presence of T-cell clusters in primary human melanoma. Disruption of LFA-1-ICAM-1 interactions, and thereby T-cell clustering, enhances the arrival of activated CD8+ T-cells to tumor draining lymph nodes in both transplanted and spontaneous cancer models. Interestingly, upon ICAM-1 blockade, the expression of the chemotactic receptor CCR7 augments in tumor in filtrating lymphocytes and in in-vitro de-clustered T cells, as well as their ability to transmigrate across lymphatic endothelial cells. We propose that ICAM-1-mediated homotypic T-lymphocyte aggregation may serve as a tumor-mediated immune retention mechanism entrapping activated CD8+ T cells in the tumor microenvironment. Modulation of T-cell adhesion may be of use to improve the transit of activated lymphocytes toward the lymph nodes and their subsequent recirculation.
Autores: Auba Guedea, Cristina; Cabello Pérez, Alvaro; García Tutor, Emilio; et al.
ISSN 2169-7574  Vol. 5  Nº 5  2017  págs. e1289
Large full-thickness chest wall reconstruction requires an alloplastic material to ensure chest wall stability, as well as a flap that provides good soft-tissue coverage. The choice not to use perforator flaps over any mesh or inert material is often based on the concern that the vascularization would be inadequate. However, perforator flaps have shown good results in several reconstructive fields, minimizing donor-site morbidity and offering versatility when local tissues are unavailable or affected by radiotherapy. In this study, we present 4 cases of patients with full-thickness chest wall defects that were repaired with a double Marlex mesh, acrylic cement (n = 2) or a double patch of Goretex (n = 2) in combination with perforator flaps (3 deep inferior epigastric artery perforators and 1 lumbar artery perforator flap). The results we obtained are encouraging, and we believe the use of perforator flaps in combination with alloplastic materials should be considered as a reliable option for full-thickness chest wall defect reconstruction.
Autores: del Pozo León, José Luis; Auba Guedea, Cristina
ISSN 0065-2598  Vol. 831  2015  págs. 53 - 67
Autores: Auba Guedea, Cristina; Cabello Pérez, Alvaro; Hontanilla Calatayud, Bernardo Carlos; et al.
ISSN 1049-2275  Vol. 26  2015  págs. e463-464
Autores: Teijeira Sánchez, Álvaro; Garasa, S.; Pelaez Cristobal, Rafael; et al.
ISSN 1523-1747  Vol. 133  Nº 9  2013  págs. 2276 - 2285
Dendritic cell (DC) transmigration across the lymphatic endothelium is critical for the initiation and sustenance of immune responses. Under noninflammatory conditions, DC transit across the lymphatic endothelial cell (LEC) has been shown to be integrin independent. In contrast, there is increasing evidence for the participation of integrins and their ligands in DC transit across lymphatic endothelium under inflammation. In this sense, we describe the formation of ICAM-1 (CD54)-enriched three-dimensional structures on LEC/DC contacts, as these DCs adhere to inflamed skin lymphatic vessels and transmigrate into them. In vitro imaging revealed that under inflammation ICAM-1 accumulated on microvilli projections surrounding 60% of adhered DCs. In contrast, these structures were scarcely formed in noninflammatory conditions. Furthermore, ICAM-1-enriched microvilli were important in promoting DC transendothelial migration and DC crawling over the LEC surface. Microvilli formation was dependent on the presence of beta-integrins on the DC side and on integrin conformational affinity to ligand. Finally, we observed that LEC microvilli structures appeared in close vicinity of CCL21 depots and that their assembly was partially inhibited by CCL21-neutralizing antibodies. Therefore, under inflammatory conditions, integrin ligands form three-dimensional membrane projections around DCs. These structures offer docking sites for DC transit from the tissue toward the lymphatic vessel lumen.
Autores: Arredondo Chaves, Jorge; Rodríguez-Spiteri Sagredo, Natalia; Torre Buxalleu, Wenceslao; et al.
ISSN 1137-6627  Vol. 36  Nº 1  2013  págs. 141 - 144
Background. Curettage mastectomy is indicated as a palliative treatment in locally advanced breast cancer. We present our experience with the use of a DIEP flap reconstruction following extensive mastectomy. Methods. We report the case of a patient with very advanced local breast cancer that was subsidiary to aggressive palliative surgery after chemotherapy. Results. It was considered that the closure that could be performed with the latissimus dorsi muscle was unsuitable, therefore a DIEP flap was performed. The patient was discharged uneventfully. Conclusion. The DIEP reconstruction offers great cutaneous extension. It can be a resource in highly selected cases of locally advanced breast cancer in which surgery becomes the main treatment.
Autores: Teijeira Sánchez, Álvaro; Palazón García, Francisco de Asís; Garasa, S; et al.
ISSN 0892-6638  Vol. 26  Nº 8  2012  págs. 3380 - 3392
Autores: Auba Guedea, Cristina; Marré Medina, Diego Antonio; Rodríguez-Losada Marco, Gonzalo; et al.
ISSN 0738-1085  Vol. 32  Nº 4  2012  págs. 261-268
Abstract The purpose of this work was to report our initial experience with lymphaticovenular anastomoses (LVA), a controversial technique for lymphedema treatment. Although LVA technique was described many years ago, the procedure is not as widespread as it was supposed to be, taking into account the high impact that lymphedema has in the quality of life of patients. Thus, 12 patients, 5 with lower limb and 7 with upper limb lymphedema, underwent LVA surgery under local anesthesia. Two patients were excluded from the study due to the lack of follow-up. At 18 months, 8 out 10 patients showed a variable objective reduction of the perimeter of the limbs and 9 patients presented a subjective clinical improvement. These results joined to the outcomes of the most experienced surgeons in this field are encouraging, although there are still many issues that need to be addressed with research to optimize the efficacy of this technique.
Autores: Rodríguez-Losada Marco, Gonzalo; Auba Guedea, Cristina; Vila Sobral, Antonio; et al.
ISSN 2171-8644  Vol. 2  Nº 5  2011  págs.  -
El carcinoma epidermoide originado de una úlcera crónica (úlcera de Marjolin) debe tratarse agresivamente incluyendo radioterapia en determinados casos. Debido a las caracteristicas de la piel radiada es importante aportar tejido sano para una cobertura adecuada. Por todo ello presentamos un caso de un tumor epidermoide originado sobre un sinus pilonidal de años de evolución que precisó de un colgajo posterior de muslo como cobertura definitiva del defecto creado.
Autores: Hontanilla Calatayud, Bernardo Carlos; Auba Guedea, Cristina
ISSN 1049-2275  Vol. 22  Nº 3  2011  págs. 845-847
Free transplant of gracilis muscle is the criterion-standard technique in dynamic rehabilitation of long-standing facial paralysis in which the facial musculature is atrophied. When the facial nerve is not available because of a bilateral lesion, other sources are the masseteric, hypoglossal, or accessory nerves. Although the use of hypoglossal nerve has been relegated to the background because of the morbidity caused by its loss, there are special situations in which the hypoglossal nerve should be considered the first option as donor motor nerve. The present article discusses the case of a patient with dynamic reanimation of bilateral facial paralysis with free-muscle transfer neurotized to the hypoglossal nerve. End-to-side coaptation of gracilis motor nerve and hypoglossal motor nerve allows neurotization of the transplanted muscle with minimum repercussion in speech or swallowing and can provide an adequate spontaneous smile with time.
Autores: Gómez Ruiz, Raul; Serra Renom, José María; Bergera Serrano, Iñaki; et al.
ISSN 0930-343X  Vol. 33  2010  págs. 135 - 142
Autores: Auba Guedea, Cristina; del Pozo León, José Luis
Libro:  Fundamental topics in plastic surgery
Nº Capítulo 6  2018  págs. 77 - 98
Autores: Hontanilla Calatayud, Bernardo Carlos; Auba Guedea, Cristina
Libro:  The sciatic nerve: blocks injuries and regeneration
2010  págs. 1-38
Autores: Hontanilla Calatayud, Bernardo Carlos (Editor literario); Auba Guedea, Cristina; Rodríguez-Losada Marco, Gonzalo; et al.