Nuestros investigadores

Irene Aquerreta González

Publicaciones científicas más recientes (desde 2010)

Autores: Leache, Leire; Aquerreta, Irene; Aldaz, Azucena; et al.
ISSN 0934-9723  Vol. 37  Nº 5  2018  págs. 799-822
The purpose of this paper was to review the literature regarding the clinical and economic impact of pharmacist interventions (PIs) related to antimicrobials in the hospital setting. A PubMed literature search from January 2003 to March 2016 was conducted using the terms pharmacist* or clinical pharmacist* combined with antimicrobial* or antibiotic* or anti-infective*. Comparative studies that assessed the clinical and/or economic impact of PIs on antimicrobials in the hospital setting were reviewed. Outcomes were classified as: treatment-related outcomes (TROs), clinical outcomes (COs), cost and microbiological outcomes (MOs). Acceptance of pharmacist recommendations by physicians was collected. PIs were grouped into patient-specific recommendations (PSRs), policy, and education. Studies' risk of bias was analyzed using Cochrane's tool. Twenty-three studies were evaluated. All of them had high risk of bias. The design in most cases was uncontrolled before and after. PSRs were included in every study; five also included policy and four education. Significant impact of PI was found in 14 of the 18 studies (77.8%) that evaluated costs, 15 of the 20 studies (75.0%) that assessed TROs, 12 of the 22 studies (54.5%) that analyzed COs, and one of the two studies (50.0%) that evaluated MOs. None of the studies found significant negative impact of PIs. It could not be concluded that adding other strategies to PSRs would improve results. Acceptance of recommendations varied from 70 to 97.5%. Pharmacists improve TROs and COs, and decrease costs. Additional research with a lower risk of bias is unlikely to change this conclusion. Future research should focus on identifying the most efficient interventions.
Autores: Leyre Leache Alegria; Aquerreta, Irene; Libe Moraza; et al.
ISSN 1695-0674  Vol. 73  Nº 22  2016  págs. 1840-1843
A 52-year-old man developed tinnitus and hearing loss after receiving high doses of oral morphine sulfate. His hearing loss did not fully resolve after the discontinuation of morphine, and he required the use of hearing aids.
Autores: Leache, Leire; Aquerreta, Irene; et al.
ISSN 1130-6343  Vol. 39  Nº 6  2015  págs. 320 - 332
Objective: to determine the incidence of linezolid-induced haematological toxicity and study the influence of renal clearance on its appearance and the preventive effect of pyridoxine. Methods: a retrospective observational study was conducted. Every patient treated with linezolid in a university hospital during 6 months was included. Haematological toxicity was defined as a decrease of 25% in hemoglobin, of 25% in platelets and/or 50% in neutrophils from baseline. The incidence of haematological toxicity and the percentage decrease in analytical variables were compared in patients with and without renal failure (creatinine clearance lower than 50 mL/min), using the 30 mL/min threshold, and with or without pyridoxine; using Chi -Square and U Mann-Whitney tests, respectively. Results: thirty-eight patients were evaluated. Sixteen (42%) presented haematological toxicity (2 due to a decrease in haemoglobin, 9 in platelets and 8 in neutrophils). Two patients (5%) discontinued treatment due to thrombocytopenia. Toxicity incidence was similar in patients with and without renal failure, 42% vs 42%, p = 0.970, with more or less than 30 ml/min, 67% vs 40%, p = 0.369, or with or without pyridoxine, 47.8% vs 33%, p = 0.376. Patients with renal failure had a significantly greater reduction in platelet count, p = 0.0185. Conclusion: forty-two percent of patients had haematological toxicity, being more frequent platelets and neutrophils reduction. This was not significantly higher in patients with renal failure or in those without pyridoxine. Greater reduction in platelet count was observed in patients with renal failure.
Autores: Lucena, Juan Felipe, (Autor de correspondencia); Alegre, Félix; Rodil, Raquel; et al.
ISSN 1553-5592  Vol. 7  Nº 5  2012  págs. 411 - 415
An ImCU led by hospitalists showed encouraging results regarding patient survival and SAPS II is an useful tool for prognostic evaluation in this population. Intermediate care serves as an expansion of role for hospitalists; and clinicians, trainees and patients may benefit from co-management and teaching opportunities at this unique level of care.
Autores: Aquerreta, Irene; Yuste, JR;
Libro:  Guía para la profilaxis y tratamiento de las infecciones y política antibiótica. 2ª ed
2015  págs. 42-78
Autores: Yuste, JR; Aquerreta, Irene;
Libro:  Guía para la profilaxis y tratamiento de las infecciones y política antibiótica. 2ª ed
2015  págs. 9-33
Autores: Aquerreta, Irene; Serrano-Alonso, M; Yuste, JR;
Libro:  Guía para la profilaxis y tratamiento de las infecciones y política antibiótica.
Nº 1ª ed  2013  págs. 31-54
Autores: Yuste, JR; Aquerreta, Irene;
Libro:  Guía para la profilaxis y tratamiento de las infecciones y política antibiótica. 1ª ed
2013  págs. 7-24