Nuestros investigadores

Irene Lucila Alustiza Quintana

Publicaciones científicas más recientes (desde 2010)

Autores: Alustiza, Irene Lucila; Garces, M. S.; Ortuno, M.; et al.
Revista: SCHIZOPHRENIA BULLETIN
ISSN 0586-7614  Vol. 44  Nº Supl.1.  2018  págs. S352
Autores: Alustiza, Irene Lucila; Radua, J.; Pla, M.; et al.
Revista: SCHIZOPHRENIA RESEARCH
ISSN 0920-9964  Vol. 188  2017  págs. 21-32
Schizophrenia (SZ) and Bipolar Disorder (BD) are associated with deficits in both timing and cognitive control functions. However, the underlying neurological dysfunctions remain poorly understood. The main goal of this study was to identify brain structures activated both by increases in cognitive activity and during timing tasks in patients with SZ and BD relative to controls. We conducted two signed differential mapping (SDM) meta-analyses of functional magnetic resonance imaging studies assessing the brain response to increasing levels of cognitive difficulty: one concerned SZ, and the other BD patients. We conducted a similar SDM meta-analysis on neuroimaging of timing in SZ (no studies in BD could be included). Finally, we carried out a multimodal meta-analysis to identify common brain regions in the findings of the two previous meta-analyses. We found that SZ patients showed hypoactivation in timing-related cortical-subcortical areas. The dysfunction observed during timing partially coincided with deficits for cognitive control functions. We hypothesize that a dysfunctional temporal/cognitive control network underlies the persistent cognitive impairment observed in SZ.
Autores: Alustiza, Irene Lucila; Radua, J.; Albajes-Eizagirre, A.; et al.
Revista: FRONTIERS IN PSYCHOLOGY
ISSN 1664-1078  Vol. 7  Nº 192  2016 
Timing and other cognitive processes demanding cognitive control become interlinked when there is an increase in the level of difficulty or effort required. Both functions are interrelated and share neuroanatomical bases. A previous meta-analysis of neuroimaging studies found that people with schizophrenia had significantly lower activation, relative to normal controls, of most right hemisphere regions of the time circuit. This finding suggests that a pattern of disconnectivity of this circuit, particularly in the supplementary motor area, is a trait of this mental disease. We hypothesize that a dysfunctional temporal/cognitive control network underlies both cognitive and psychiatric symptoms of schizophrenia and that timing dysfunction is at the root of the cognitive deficits observed. The goal of our study was to look, in schizophrenia patients, for brain structures activated both by execution of cognitive tasks requiring increased effort and by performance of time perception tasks. We conducted a signed differential mapping (SDM) meta-analysis of functional neuroimaging studies in schizophrenia patients assessing the brain response to increasing levels of cognitive difficulty. Then, we performed a multimodal meta-analysis to identify common brain regions in the findings of that SDM meta-analysis and our previously-published activation likelihood estimate (ALE) meta-analysis of neuroimaging of time perception in schizophrenia patients. The current study supports the hypothe
Autores: Alustiza, Irene Lucila; Pujol, Nuria; Molero, Patricio; et al.
Revista: SCHIZOPHRENIA RESEARCH
ISSN 0920-9964  Vol. 2   Nº 4  2015  págs. 185 - 188
We review the main contributions of the cognitive neuroscience literature in the field of time processing in schizophrenia. First, we summarize the theoretical concepts and terminology related to time and time estimation and the characterization of this deficit in the illness. Second, we thoroughly review the neuroanatomical basis of this deficit and its interactions with other cognitive processes and clinical symptoms. Third, we specifically highlight the main findings of studies that have analyzed temporal discrimination using cognitive tasks performed during functional neuroimaging. Summary This review aims to summarize the main findings of the neuroscientific and cognitive literature on temporality in schizophrenia. First, we will provide a brief introduction regarding the theoretical and conceptual issues and then will delve into the importance of their disturbance in this disorder, particularly underlying brain structures and the interactions they have with other cognitive dysfunctions and psychopathological symptoms. This review includes different studies that describe both behavioral and neuroscientific approaches, although it focuses especially on tasks of temporal discrimination on the milliseconds scale and on the studies that use functional neuroimaging techniques.
Autores: Alustiza, Irene Lucila; Pujol, Nuria; Molero, Patricio; et al.
Revista: SCHIZOPHRENIA RESEARCH: COGNITION
ISSN 2215-0013  Vol. 2  Nº 15  2015  págs. 210-213
Autores: Ortuño, Felipe; Alustiza, Irene Lucila;
Revista: MEDICAL HYPOTHESES
ISSN 0306-9877  Vol. 83  Nº 4  2014  págs. 509 - 510
Autores: Ortuño, Felipe; Alustiza, Irene Lucila;
Revista: MEDICAL HYPOTHESES
ISSN 0306-9877  Vol. 83  2014  págs. 509-515