Journals
Journal:
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
ISSN:
1051-0443
Year:
2023
Vol.:
34
N°:
1
pp.
21 - 22
Journal:
INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN BIOMEDICAL ENGINEERING
ISSN:
2040-7939
Year:
2022
Vol.:
38
N°:
4
pp.
e3577
Radioembolization (RE) is a medical treatment for primary and secondary liver cancer that involves the transcatheter intraarterial delivery of micron-sized and radiation-emitting microspheres, with the goal of improving microsphere deposition in the tumoral bed while sparing healthy tissue. An increasing number of in vitro and in silico studies on RE in the literature suggest that the particle injection velocity, spatial location of the catheter tip and catheter type are important parameters in particle distribution. The present in silico study assesses the performance of a novel catheter design that promotes particle dispersion near the injection point, with the goal of generating a particle distribution that mimics the flow split to facilitate tumour targeting. The design is based on two factors: the direction and the velocity at which particles are released from the catheter. A series of simulations was performed with the catheter inserted at an idealised hepatic artery tree with physiologically realistic boundary conditions. Two longitudinal microcatheter positions in the first generation of the tree were studied by analysing the performance of the catheter in terms of the outlet-to-outlet particle distribution and split flow matching. The results show that the catheter with the best performance is one with side holes on the catheter wall and a closed frontal tip. This catheter promotes a flow-split-matching particle distribution, which improves as the injection crossflow increases.
Journal:
MATHEMATICS
ISSN:
2227-7390
Year:
2022
Vol.:
10
N°:
2
pp.
4280
Computational fluid dynamics techniques are increasingly used to computer simulate radioembolization, a transcatheter intraarterial treatment for patients with inoperable tumors, and analyze the influence of treatment parameters on the microsphere distribution. Ongoing clinical research studies are exploring the influence of the microsphere density in tumors on the treatment outcome. In this preliminary study, we computationally analyzed the influence of the microsphere concentration in the vial on the microsphere concentration in the blood. A patient-specific case was used to simulate the blood flow and the microsphere transport during three radioembolization procedures in which the only parameter varied was the concentration of microspheres in the vial and the span of injection, resulting in three simulations with the same number of microspheres injected. Results showed that a time-varying microsphere concentration in the blood at the outlets of the computational domain can be analyzed using CFD, and also showed that there was a direct relationship between the variation of microsphere concentration in the vial and the variation of microsphere concentration in the blood. Future research will focus on elucidating the relationship between the microsphere concentration in the vial, the microsphere concentration in the blood, and the final microsphere distribution in the tissue.
Journal:
EKAIA
ISSN:
0214-9001
Year:
2022
Vol.:
42
pp.
339 - 348
Erradioenbolizazioa (RE) gibeleko minbizia tratatzeko metodoetako bat da. Bertan, mikrokateter bidez gibeleko arterian mikroesfera erradioaktiboak injektatzen dira, hauek tumoreak enbolizazio eta erradiazio bidez erasotzeko. Mikroesferen ibilbidea ordenagailu bidezko fluido dinamika simulazioekin (CFD) aztertu daiteke. Kalkulu hauen iraupen luzea arazo bat da medikuntzaren egunerokotasunean simulazioak erabili ahal izateko. Kalkuluak azkartzeko asmoz, odolaren biskositatearen izaera ez¿newtondarra izaera newtondarrera sinplifikatu da. Emaitzek erakutsi dute mikroesferen banaketan eta odolaren hemodinamikan biskositate aldakorraren eragina mespretxagarria dela, odola fluido newtondar bezala aztertzearen sinplifikazioa ontzat emanez.
Journal:
CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY
ISSN:
0174-1551
Year:
2022
Vol.:
45
N°:
7
pp.
970 - 971
Journal:
SCIENTIFIC REPORTS
ISSN:
2045-2322
Year:
2021
Vol.:
11
N°:
1
pp.
3895
Radioembolization (RE) with yttrium-90 (Y-90) microspheres, a transcatheter intraarterial therapy for patients with liver cancer, can be modeled computationally. The purpose of this work was to correlate the results obtained with this methodology using in vivo data, so that this computational tool could be used for the optimization of the RE procedure. The hepatic artery three-dimensional (3D) hemodynamics and microsphere distribution during RE were modeled for six Y-90-loaded microsphere infusions in three patients with hepatocellular carcinoma using a commercially available computational fluid dynamics (CFD) software package. The model was built based on in vivo data acquired during the pretreatment stage. The results of the simulations were compared with the in vivo distribution assessed by Y-90 PET/CT. Specifically, the microsphere distribution predicted was compared with the actual Y-90 activity per liver segment with a commercially available 3D-voxel dosimetry software (PLANET Dose, DOSIsoft). The average difference between the CFD-based and the PET/CT-based activity distribution was 2.36 percentage points for Patient 1, 3.51 percentage points for Patient 2 and 2.02 percentage points for Patient 3. These results suggest that CFD simulations may help to predict Y-90-microsphere distribution after RE and could be used to optimize the RE procedure on a patient-specific basis.
Journal:
MATHEMATICS
ISSN:
2227-7390
Year:
2021
Vol.:
9
N°:
8
pp.
839
Radioembolization (RE) is a treatment for patients with liver cancer, one of the leading cause of cancer-related deaths worldwide. RE consists of the transcatheter intraarterial infusion of radioactive microspheres, which are injected at the hepatic artery level and are transported in the bloodstream, aiming to target tumors and spare healthy liver parenchyma. In paving the way towards a computer platform that allows for a treatment planning based on computational fluid dynamics (CFD) simulations, the current simulation (model preprocess, model solving, model postprocess) times (of the order of days) make the CFD-based assessment non-viable. One of the approaches to reduce the simulation time includes the reduction in size of the simulated truncated hepatic artery. In this study, we analyze for three patient-specific hepatic arteries the impact of reducing the geometry of the hepatic artery on the simulation time. Results show that geometries can be efficiently shortened without impacting greatly on the microsphere distribution.
Authors:
Mariscal Harana, J. (Autor de correspondencia); Charlton, P. H. ; Vennin, S.; et al.
Journal:
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
ISSN:
0363-6135
Year:
2021
Vol.:
320
N°:
2
pp.
H494 - H510
Central blood pressure (cBP) is a highly prognostic cardiovascular (CV) risk factor whose accurate, invasive assessment is costly and carries risks to patients. We developed and assessed novel algorithms for estimating cBP from noninvasive aortic hemodynamic data and a peripheral blood pressure measurement. These algorithms were created using three blood flow models: the two- and three-element Windkessel (0-D) models and a one-dimensional (1-D) model of the thoracic aorta. We tested new and existing methods for estimating CV parameters (left ventricular ejection time, outflow BP, arterial resistance and compliance, pulse wave velocity, and characteristic impedance) required for the cBP algorithms, using virtual (simulated) subjects (n = 19,646) for which reference CV parameters were known exactly. We then tested the cBP algorithms using virtual subjects (n = 4,064), for which reference cBP were available free of measurement error, and clinical datasets containing invasive (n = 10) and noninvasive (n = 171) reference cBP waves across a wide range of CV conditions. The 1-D algorithm outperformed the O-D algorithms when the aortic vascular geometry was available, achieving central systolic blood pressure (cSBP) errors <= 2.1 +/- 9.7 mmHg and root-mean-square errors (RMSEs) <= 6.4 +/- 2.8 mmHg against invasive reference cBP waves (n = 10). When the aortic geometry was unavailable, the three-element 0-D algorithm achieved cSBP errors <= 6.0 +/- 4.7 mmHg and RMSEs <= 5.9 +/- 2.4 mmHg against noninvasive reference cBP waves (n = 171), outperforming the two-element O-D algorithm. All CV parameters were estimated with mean percentage errors <= 8.2%, except for the aortic characteristic impedance (<13.4%), which affected the three-element O-D algorithm's performance. The freely available algorithms developed in this work enable fast and accurate calculation of the cBP wave and CV parameters in datasets containing noninvasive ultrasound or magnetic resonance imaging data. NEW & NOTEWORTHY First, our proposed methods for CV parameter estimation and a comprehensive set of methods from the literature were tested using in silico and clinical datasets. Second, optimized algorithms for estimating cBP from aortic flow were developed and tested for a wide range of cBP morphologies, including catheter cBP data. Third, a dataset of simulated cBP waves was created using a three-element Windkessel model. Fourth, the Windkessel model dataset and optimized algorithms are freely available.
Journal:
BIOLOGY
ISSN:
2079-7737
Year:
2021
Vol.:
10
N°:
12
pp.
1341
Simple Summary Liver cancer is one of the leading causes of cancer-related deaths worldwide and balloon-occluded transarterial chemoembolization (B-TACE) has emerged as a safe and effective treatment for liver cancer. However, the hemodynamic alterations that are responsible for the successfulness of the treatment and are produced by the microballoon catheter used during the treatment are not yet well understood. In this study, we developed an in vitro model (IVM) that can simulate B-TACE. We designed clinically relevant experiments, and we obtained clinically realistic results. We conclude that the IVM allows for a visual understanding of a complex phenomenon (i.e., the blood flow redistribution after balloon occlusion) and it could be used as a base for future sophisticated and even patient-specific IVMs; in addition, it could be used to conduct IVM-based research on B-TACE. Background: Balloon-occluded transarterial chemoembolization (B-TACE) has emerged as a safe and effective procedure for patients with liver cancer, which is one of the deadliest types of cancer worldwide. B-TACE consist of the transcatheter intraarterial infusion of chemotherapeutic agents, followed by embolizing particles, and it is performed with a microballoon catheter that temporarily occludes a hepatic artery. B-TACE relies on the blood flow redistribution promoted by the balloon-occlusion. However, flow redistribution phenomenon is not yet well understood. Methods: This study aims to present a simple in vitro model (IVM) where B-TACE can be simulated. Results: By visually analyzing the results of various clinically-realistic experiments, the IVM allows for the understanding of balloon-occlusion-related hemodynamic changes and the importance of the occlusion site. Conclusion: The IVM can be used as an educational tool to help clinicians better understand B-TACE treatments. This IVM could also serve as a base for a more sophisticated IVM to be used as a research tool.
Journal:
DYNA
ISSN:
0012-7361
Year:
2020
Vol.:
95
N°:
6
pp.
640 - 645
The air conditioning systems used in transport vehicles (railway passenger cars) are constrained by two issues: the consumed energy and the occupied space. In order to assess how both restrictions can be fulfilled a parametric analysis and an optimization have been carried out by means of Design of Experiments (DoE) techniques applied to a mathematical model of a real AC system. To evaluate the energy efficiency of the system four parameters have been used: the COP (Coefficient of Performance), the refrigeration power of the system and its dimensionless expression and the effectiveness of the evaporator. The occupied space of the AC system has been characterized through the dimensionless volume of the evaporator. The same compressor has been used in the analysis and the input parameters varied have been the dimensionless evaporator volume and four operating conditions: the evaporator inlet air temperature and mass flow rate, the condenser inlet air temperature and the air temperature increment in the condenser. Through a Central Composite Surface Response design, results show that the dimensionless refrigeration power is the best parameter to assess the energy efficiency because is independent of the operating conditions and only depends on the dimensionless volume of the evaporator: the lower the latter, the higher the former. An optimal dimensionless volume has been identified for the simultaneous optimization of the four output variables of the system that provides an increase of 26% in the dimensionless refrigeration power with respect to the baseline system.
Journal:
INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN BIOMEDICAL ENGINEERING
ISSN:
2040-7939
Year:
2020
Vol.:
36
N°:
6
pp.
e3337
In the last decades, the numerical studies on hemodynamics have become a valuable explorative scientific tool. The very first studies were done over idealized geometries, but as numerical methods and the power of computers have become more affordable, the studies tend to be patient specific. We apply the study to the numerical analysis of tumor-targeting during liver radioembolization (RE). RE is a treatment for liver cancer, and is performed by injecting radiolabeled microspheres via a catheter placed in the hepatic artery. The objective of the procedure is to maximize the release of radiolabeled microspheres into the tumor and avoid a healthy tissue damage. Idealized virtual arteries can serve as a generalist approach that permits to separately analyze the effect of a variable in the microsphere distribution with respect to others. However, it is important to use proper physiological boundary conditions (BCs). It is not obvious, the need to account for the effect of tortuosity when using an idealized virtual artery. We study the use of idealized geometry of a hepatic artery as a valid research tool, exploring the importance of using realistic spiral-flow inflow BC. By using a literature-based cancer scenario, we vary two parameters to analyze the microsphere distribution through the outlets of the geometry. The parameters varied are the type of microspheres injected and the microsphere injection velocity. The results with realistic inlet velocity profile showed that the par
Journal:
COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING
ISSN:
1025-5842
Year:
2019
Vol.:
22
N°:
5
pp.
518 - 532
Balloon-occluded transarterial chemoembolisation (B-TACE) is an intraarterial transcatheter treatment for liver cancer. In B-TACE, an artery-occluding microballoon catheter occludes an artery and promotes collateral circulation for drug delivery to tumours. This paper presents a methodology for analysing the haemodynamics during B-TACE, by combining zero-dimensional and three-dimensional modelling tools. As a proof of concept, we apply the methodology to a patient-specific hepatic artery geometry and analyse two catheter locations. Results show that the blood flow redistribution can be predicted in this proof-of-concept study, suggesting that this approach could potentially be used to optimise catheter location.
Journal:
INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN BIOMEDICAL ENGINEERING
ISSN:
2040-7939
Year:
2018
Vol.:
34
N°:
7
pp.
e2983
Journal:
INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN BIOMEDICAL ENGINEERING
ISSN:
2040-7939
Year:
2017
Vol.:
33
N°:
2
Liver radioembolization (RE) is a treatment option for patients with unresectable and chemorefractory primary and metastatic liver tumours. RE consists of intra-arterially administering via catheter radioactive microspheres that locally attack the tumours, sparing healthy tissue. Prior to RE, the standard practice is to conduct a treatment-mimicking pretreatment assessment via the infusion of Tc-99m-labelled macroaggregated albumin microparticles. The usefulness of this pretreatment has been debated in the literature, and thus, the aim of the present study is to shed light on this issue by numerically simulating the liver RE pretreatment and actual treatment particle-haemodynamics in a patient-specific hepatic artery under two different literature-based cancer scenarios and two different placements of a realistic end-hole microcatheter in the proper hepatic artery. The parameters that are analysed are the following: microagent quantity and size (accounting for RE pretreatment and treatment), catheter-tip position (near the proper hepatic artery bifurcation and away from it), and cancer burden (10% and 30% liver involvement). The conclusion that can be reached from the simulations is that when it comes to mimicking RE in terms of delivering particles to tumour-bearing segments, the catheter-tip position is much more important (because of the importance of local haemodynamic pattern alteration) than the infused microagents (i.e. quantity and size). Cancer burden is another important feature because the increase in blood flow rate to tumour-bearing segments increases the power to drag particles. These numerical simulation-based conclusions are in agreement with clinically observed events reported in the literature. Copyright (c) 2016 John Wiley & Sons, Ltd.
Journal:
INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN BIOMEDICAL ENGINEERING
ISSN:
2040-7939
Liver radioembolization is a promising treatment option for combating liver tumors. It is performed by placing a microcatheter in the hepatic artery and administering radiation-emitting microspheres through the arterial bloodstream so that they get lodged in the tumoral bed. In avoiding nontarget radiation, the standard practice is to conduct a pretreatment, in which the microcatheter location and injection velocity are decided. However, between pretreatment and actual treatment some of the parameters that influence the particle distribution in the liver can vary, resulting in radiation-induced complications. The present study aims to analyze the influence of a commercially available microcatheter with an angled tip and particle injection velocity in terms of segment-to-segment particle distribution. Specifically, four tip orientations and two injection velocities are combined to yield a set of eight numerical simulations of the particle-hemodynamics in a patient-specific truncated hepatic artery. For each simulation, four cardiac pulses are simulated. Particles are injected during the first cycle, and the remaining pulses enable the majority of the injected particles to exit the computational domain. Results indicate that, in terms of injection velocity, particles are more spread out in the cross-sectional lumen areas as the injection velocity increases. The tip's orientation also plays a role because it influences the near-tip hemodynamics, therefore altering the particle travel through the hepatic artery. However, results suggest that particle distribution tries to match the blood flow split, therefore particle injection velocity and microcatheter tip orientation playing a minor role in segment-to-segment particle distribution.
Journal:
BIOMEDICAL PHYSICS AND ENGINEERING EXPRESS
ISSN:
2057-1976
Year:
2016
Vol.:
2
N°:
1
pp.
015001
The analysis of the progression of cardiovascular diseases is an active area of ongoing research. This paper develops an image registration-based methodology to quantify the patient-specific local blood vessel shape variations that occur in the radial direction (i.e. expansion or shrinkage) over an imaging follow-up period, and an example is presented as proof of principle. The methodology can be used for complex vessels with bifurcations, and it is able to identify and address vessel deformations if changes in tortuosity or longitudinal direction are small. The methodology consists of (a) overlapping the baseline and follow-up vessel surfaces by matching the lumen centerline, (b) dividing the region of interest into slices perpendicular to the centerline and centering each slice, and (c) dividing each centered slice into sectors. The local approach consists of analyzing a representative point in each sector of each slice (i.e. each patch). In this paper the algorithm is applied to a patient-specific abdominal aortic aneurysm (AAA) as a proof of principle of the method. Six patient-specific image reconstructions from a single subject followed for 28 months are analyzed in pairs, yielding five time spans to which the algorithm was applied. The algorithm was able to quantify the AAA radial growth. The average AAA radial growths for the five case studies are ¿2.13 mm, 3.43 mm, ¿0.25 mm, 1.41 mm, and 0.84 mm, whereas the maximum local growths are 4.76 ± 0.15 mm, 9.30 ± 1.13 mm, 2.08 ± 0.05 mm, 4.10 ± 0.14 mm, and 4.16 ± 0.45 mm. The tolerance of the geometric local measurements is related to the matching processes (i.e. overlapping the geometries and centering each slice) because of the vessel deformation that took place over time. Thus, this methodology has been used to quantify the average AAA growth and the maximum local AAA growth (± the tolerance) as metrics of the vessel's radial growth.
Journal:
JOURNAL OF BIOMECHANICS
ISSN:
0021-9290
Year:
2016
Vol.:
49
N°:
15
pp.
3705 - 3713
Radioembolization, which consist of the implantation of radioactive microspheres via intra-arterially placed microcatheter, is a safe and effective treatment for liver cancer. Nevertheless, radioembolization-related complications and side effects may arise, which are an active area of ongoing research. The catheter design has been claimed as an option in reducing these complications. In this paper, the influence of catheter type and location are investigated. The study was undertaken by numerically simulating the particle¿hemodynamics in a patient-specific hepatic artery during liver radioembolization. The parameters modified were cancer scenario (30% liver involvement in the right lobe, `scenario A¿, and in both lobes, `scenario B¿), catheter type (standard end-hole microcatheter, SMC, and antireflux catheter, ARC), and the location of the tip in the proper hepatic artery (in the straight part, `inlet¿, and near the bifurcation, `bifurcation¿). Comparing ARC with SMC, the maximum and average (over segments) absolute difference in the percentage of particles that reached each segment were 19.62% and 9.06% when injecting near the inlet for scenario A; 3.54% and 1.07% injecting near the bifurcation for scenario A; and 18.31% and 11.85% injecting near the inlet for scenario B. It seems, therefore, that the location of the catheter tip in the artery is crucial in terms of particle distribution. Moreover, even though the near-tip blood flow was altered due to the presence of a catheter, the particle distribution matched the flow split if the distance between the injection point and the first bifurcation encountered enabled the alignment of particles with blood flow.
Journal:
INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN BIOMEDICAL ENGINEERING
ISSN:
2040-7939
Year:
2016
Vol.:
32
N°:
11
pp.
e02764
Some of the latest treatments for unresectable liver malignancies (primary or metastatic tumours), which include bland embolisation, chemoembolisation, and radioembolisation, among others, take advantage of the increased arterial blood supply to the tumours to locally attack them. A better understanding of the factors that influence this transport may help improve the therapeutic procedures by taking advantage of flow patterns or by designing catheters and infusion systems that result in the injected beads having increased access to the tumour vasculature. Computational analyses may help understand the haemodynamic patterns and embolic-microsphere transport through the hepatic arteries. In addition, physiological inflow and outflow boundary conditions are essential in order to reliably represent the blood flow through arteries. This study presents a liver cancer arterial perfusion model based on a literature review and derives boundary conditions for tumour-bearing liver-feeding hepatic arteries based on the arterial perfusion characteristics of normal and tumorous liver segment tissue masses and the hepatic artery branching configuration. Literature-based healthy and tumour-bearing realistic scenarios are created and haemodynamically analysed for the same patient-specific hepatic artery. As a result, this study provides boundary conditions for computational fluid dynamics simulations that will allow researchers to numerically study, for example, various intravascular devices
Journal:
JOURNAL OF BIOMECHANICS
ISSN:
0021-9290
Year:
2016
Vol.:
49
N°:
15
pp.
3714 - 3721
Liver radioembolization is a treatment option for patients with primary and secondary liver cancer. The procedure consists of injecting radiation-emitting microspheres via an intra-arterially placed microcatheter, enabling the deposition of the microspheres in the tumoral bed. The microcatheter location and the particle injection rate are determined during a pretreatment work-up. The purpose of this study was to numerically study the effects of the injection characteristics during the first stage of microsphere travel through the bloodstream in a patient-specific hepatic artery (i.e., the near-tip particle¿hemodynamics and the segment-to-segment particle distribution). Specifically, the influence of the distal direction of an end-hole microcatheter and particle injection point and velocity were analyzed. Results showed that the procedure targeted the right lobe when injecting from two of the three injection points under study and the remaining injection point primarily targeted the left lobe. Changes in microcatheter direction and injection velocity resulted in an absolute difference in exiting particle percentage for a given liver segment of up to 20% and 30%, respectively. It can be concluded that even though microcatheter placement is presumably reproduced in the treatment session relative to the pretreatment angiography, the treatment may result in undesired segment-to-segment particle distribution and therefore undesired treatment outcomes due to modifications of any of the parameters studied, i.e., microcatheter direction and particle injection point and velocity.
Journal:
PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART H-JOURNAL OF ENGINEERING IN MEDICINE
ISSN:
0954-4119
Year:
2015
Vol.:
229
N°:
4
pp.
291 - 306
Physiological outflow boundary conditions are necessary to carry out computational fluid dynamics simulations that reliably represent the blood flow through arteries. When dealing with complex three-dimensional trees of small arteries, and therefore with multiple outlets, the robustness and speed of convergence are also important. This study derives physiological outflow boundary conditions for cases in which the physiological values at those outlets are not known (neither in vivo measurements nor literature-based values are available) and in which the tree exhibits symmetry to some extent. The inputs of the methodology are the three-dimensional domain and the flow rate waveform and the systolic and diastolic pressures at the inlet. The derived physiological outflow boundary conditions, which are a physiological pressure waveform for each outlet, are based on the results of a zero-dimensional model simulation. The methodology assumes symmetrical branching and is able to tackle the flow distribution problem when the domain outlets are at branches with a different number of upstream bifurcations. The methodology is applied to a group of patient-specific arteries in the liver. The methodology is considered to be valid because the pulsatile computational fluid dynamics simulation with the inflow flow rate waveform (input of the methodology) and the derived outflow boundary conditions lead to physiological results, that is, the resulting systolic and diastolic pressures at the inlet match the inputs of the methodology, and the flow split is also physiological.
National and regional funding
Title:
Estudio de la viabilidad del desarrollo de una herramienta basada en simulación numérica para la mejora de la radioembolización en tumores hepáticos, RADIOSIM
Project reference:
2023-CIEN-000025-01
Principal Investigator:
Raúl Antón Remírez, Jorge Aramburu Montenegro
Funding organisation:
DIPUTACIÓN FORAL DE GIPUZKOA
Programme/Call:
2023 Programa de Red Guipuzcoana de Ciencia, Tecnología e Innovación
Starting date:
18/04/2023
Ending date:
30/09/2024
Amount awarded:
70.976,00€
Other Funds:
-
Title:
Estudio de la viabilidad del desarrollo de una herramienta basada en simulación numérica para la mejora de tratamientos transcatéter intraarteriales para tumores hepáticos (HEMOSIM)
Project reference:
2021-CIEN-000076-01
Principal Investigator:
Jorge Aramburu Montenegro
Funding organisation:
DIPUTACIÓN FORAL DE GIPUZKOA
Programme/Call:
Programa Red guipuzcoana de Ciencia, Tecnología e Innovación_DFG 2021
Starting date:
09/06/2021
Ending date:
30/09/2022
Amount awarded:
56.470,00€
Other Funds:
-
Title:
Modelización y Diagnóstico de Transformadores (MODITRANS)
Project reference:
CPP2021-008580
Principal Investigator:
Juan Carlos Ramos González
Funding organisation:
AGENCIA ESTATAL DE INVESTIGACION
Programme/Call:
2021 AEI Proyectos en Colaboración Público Privada
Starting date:
01/07/2022
Ending date:
30/09/2025
Amount awarded:
277.334,09€
Other Funds:
-
Title:
Modelización Térmica de Transformadores para aplicaciones fotovoltaicas.
Project reference:
KK-2020/00004
Principal Investigator:
Juan Carlos Ramos González
Funding organisation:
EUSKO JAURLARITZA - GOBIERNO VASCO
Programme/Call:
Programa Elkartek 2020 (K2) Proyectos de investigacion con alto potencial industrial
Starting date:
01/04/2020
Ending date:
31/12/2021
Amount awarded:
61.500,00€
Other Funds:
-
Title:
Modelización térmica de transformadores para aplicaciones fotovoltaicas II, (TRANSMOD II)
Project reference:
KK-2021/00021
Principal Investigator:
Juan Carlos Ramos González
Funding organisation:
EUSKO JAURLARITZA - GOBIERNO VASCO
Programme/Call:
Programa Elkartek 2021 (K2) Proyectos de Investigación con alto Potencial Industrial
Starting date:
01/03/2021
Ending date:
31/12/2022
Amount awarded:
32.332,67€
Title:
Sistemas de aplicación de adhesivo termofusible (SISIVO)
Project reference:
RTC2019-007057-7
Principal Investigator:
Alejandro Rivas Nieto
Funding organisation:
MINISTERIO DE CIENCIA, INNOVACIÓN Y UNIVERSIDADES
Programme/Call:
2019 AEI RETOS COLABORACIÓN
Starting date:
01/01/2020
Ending date:
21/12/2022
Amount awarded:
151.152,60€
Other Funds:
-
