ARTÍCULO

Genetics of weight loss: a basis for personalized obesity management

Autores: Martínez Hernández, Alfredo; Milagro Yoldi, Fermín Ignacio
Título de la revista: TRENDS IN FOOD SCIENCE AND TECHNOLOGY
ISSN: 0924-2244
Volumen: 42
Número: 2
Páginas: 97 - 115
Fecha de publicación: 2015
Resumen:
A personalized nutritional approach, based not only on phenotypic traits but also on genetic make-up, may help to control body weight and obesity. Recent advances in nutrigenetics, bioinformatics and genome-wide association/metabolomic/metagenomic studies are set to unleash a revolution in personalized nutrition. This article performs a systematic review of nutrigenetic data concerning single nucleotide polymorphisms (SNPs) involved in weight loss that are considered polygenic. SNPs located in or near FTO, MC4R, MC3R, POMC, LEP, LEPR, PLIN1, APOA5, LIPC, FABP2, INSIG2, IRS1, GIPR, ADBR2, ADRB3, UCP1, RETN, ADIPOQ, IL6, PPARG, TCF7L2, and CLOCK, among others, are comprehensively reviewed.