ARTÍCULO

Edelfosine lipid nanosystems overcome drug resistance in leukemic cell lines

Autores: Lasa Saracíbar, Beatriz; Estella Hermoso de Mendoza, Ander; Mollinedo, F. ; Odero de Dios, María Dolores; Blanco Prieto, María José
Título de la revista: CANCER LETTERS
ISSN: 0304-3835
Volumen: 334
Número: 2
Páginas: 302 - 310
Fecha de publicación: 2013
Resumen:
Although current therapies have improved leukemia survival rates, adverse drug effects and relapse are frequent. Encapsulation of edelfosine (ET) in lipid nanoparticles (LNs) improves its oral bioavailability and decreases its toxicity. Here we evaluated the efficacy of ET-LN in myeloid leukemia cell lines. Drug-loaded LN were as effective as free ET in sensitive leukemia cell lines. Moreover, the encapsulated drug overcame the resistance of the K562 cell line to the drug. LN containing ET might be used as a promising drug delivery system in leukemia due to their capacity to overcome the in vivo pitfalls of the free drug and their efficacy in vitro in leukemia cell lines.