ARTÍCULO

In vitro and in vivo selective antitumor activity of edelfosine against mantle cell lymphoma and chronic lymphocytic leukemia involving lipid rafts

Autores: Mollinedo, F; De la Iglesia-Vicente, J; Gajate, C; Estella Hermoso de Mendoza, Ander; Villa-Pulgarin, JA; de Frías, M; Roué, G; Gil, J; Colomer, D; Campanero Martínez, Miguel Ángel; Blanco Prieto, María José
Título de la revista: CLINICAL CANCER RESEARCH
ISSN: 1078-0432
Volumen: 16
Número: 7
Páginas: 2046 - 2054
Fecha de publicación: 2010
Resumen:
Our data indicate that edelfosine accumulates and kills MCL and CLL cells in a rather selective way, and set coclustering of Fas/CD95 and lipid rafts as a new framework in MCL and CLL therapy. Our data support a selective antitumor action of edelfosine.