ARTÍCULO

Role of CFH and ARMS2 polymorphins in retinopathy and coronary artery disease in type 1 diabetes

Autores: Toni García, Marta; Hermida Santos, José María; Toledo Atucha, Estefanía Ainhoa; Goñi, M. J.; Díez Goñi, María de las Nieves
Título de la revista: ANALES DEL SISTEMA SANITARIO DE NAVARRA
ISSN: 1137-6627
Volumen: 35
Número: 3
Páginas: 425 - 432
Fecha de publicación: 2012
Resumen:
BACKGROUND: Type 1 diabetes is associated with vascular morbidity. The aim of this study was to evaluate the role of polymorphisms rs1410996 CFH and rs10490924 ARMS2 with proliferative diabetic retinopathy and coronary disease in type 1 diabetes patients. MATERIAL AND METHODS: We present a retrospective study that analyses the clinical characteristics and the polymorphisms rs1410996 CFH and rs10490924 ARMS2 of 147 type 1 diabetes patients. RESULTS: The patients who developed proliferative diabetic retinopathy in the first 20 years carried the rs1410996 CFH polymorphism. The overall risk-allele frequency was significantly higher among patients with coronary artery disease than in those without it (75 vs. 53%, p<0.001). CONCLUSIONS: rs1410996 CFH polymorphism could be associated with both proliferative diabetic retinopathy and coronary artery disease in type 1 diabetes patients. However, rs10490924 ARMS2 does not seem to be associated either with retinopathy or coronary artery disease.